Peptic ulcer historical perspective: Difference between revisions
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{{Peptic ulcer}}{{CMG}} | {{Peptic ulcer}}{{CMG}} | ||
==Overview== | ==Overview== | ||
{{see also|Timeline of peptic ulcer disease and Helicobacter pylori}} | |||
In 1997, the [[Centers for Disease Control and Prevention]], with other government agencies, academic institutions, and industry, launched a national education campaign to inform health care providers and consumers about the link between ''[[H. pylori]]'' and ulcers. This campaign reinforced the news that ulcers are a curable infection, and the fact that health can be greatly improved and money saved by disseminating information about ''H. pylori''.<ref>[http://www.cdc.gov/ulcer/history.htm Ulcer, Diagnosis and Treatment - CDC Bacterial, Mycotic Diseases]</ref> | |||
''[[Helicobacter pylori]]'' was rediscovered in 1982 by two Australian scientists [[Robin Warren]] and [[Barry Marshall]]<ref>{{cite journal|author=Marshall BJ|title=Unidentified curved bacillus on gastric epithelium in active chronic gastritis|journal=[[The Lancet|Lancet]]|year=1983|volume=1|issue=8336|pages=1273–1275|id=PMID 6134060}}</ref>. In their original paper, Warren and Marshall contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by [[stress (medicine)|stress]] or [[spicy food]] as had been assumed before.<ref>{{cite journal|author=Marshall BJ, Warren JR|title=Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration|journal=Lancet|year=1984|volume=1|issue=8390|pages=1311–1315|id=PMID 6145023}}</ref> | |||
The ''[[H. pylori]]'' hypothesis was poorly received, so in an act of self-experimentation Marshall drank a petri-dish containing a culture of organisms extracted from a patient and soon developed gastritis. His symptoms disappeared after two weeks, but he took antibiotics to kill the remaining bacteria at the urging of his wife, since [[halitosis]] is one of the symptoms of infection.<ref name="mja">{{cite web | url= http://www.mja.com.au/public/issues/183_11_051205/van11000_fm.html#0_i1091639| title=Research Enterprise, The 2005 Nobel Prize in Physiology or Medicine |accessdate=2007-08-26}}</ref> This experiment was published in 1984 in the Australian Medical Journal and is among the most cited articles from the journal. | |||
In 2005, the Karolinska Institute in Stockholm awarded the [[Nobel Prize in Physiology or Medicine]] to Dr. Marshall and his long-time collaborator Dr. [[Robin Warren|Warren]] "for their discovery of the bacterium ''Helicobacter pylori'' and its role in [[gastritis]] and peptic ulcer disease". Professor Marshall continues research related to ''H. pylori'' and runs a molecular biology lab at UWA in Perth, Western Australia. | |||
==References== | ==References== | ||
Revision as of 19:17, 3 February 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
In 1997, the Centers for Disease Control and Prevention, with other government agencies, academic institutions, and industry, launched a national education campaign to inform health care providers and consumers about the link between H. pylori and ulcers. This campaign reinforced the news that ulcers are a curable infection, and the fact that health can be greatly improved and money saved by disseminating information about H. pylori.[1]
Helicobacter pylori was rediscovered in 1982 by two Australian scientists Robin Warren and Barry Marshall[2]. In their original paper, Warren and Marshall contended that most stomach ulcers and gastritis were caused by colonization with this bacterium, not by stress or spicy food as had been assumed before.[3]
The H. pylori hypothesis was poorly received, so in an act of self-experimentation Marshall drank a petri-dish containing a culture of organisms extracted from a patient and soon developed gastritis. His symptoms disappeared after two weeks, but he took antibiotics to kill the remaining bacteria at the urging of his wife, since halitosis is one of the symptoms of infection.[4] This experiment was published in 1984 in the Australian Medical Journal and is among the most cited articles from the journal.
In 2005, the Karolinska Institute in Stockholm awarded the Nobel Prize in Physiology or Medicine to Dr. Marshall and his long-time collaborator Dr. Warren "for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease". Professor Marshall continues research related to H. pylori and runs a molecular biology lab at UWA in Perth, Western Australia.
References
- ↑ Ulcer, Diagnosis and Treatment - CDC Bacterial, Mycotic Diseases
- ↑ Marshall BJ (1983). "Unidentified curved bacillus on gastric epithelium in active chronic gastritis". Lancet. 1 (8336): 1273–1275. PMID 6134060.
- ↑ Marshall BJ, Warren JR (1984). "Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration". Lancet. 1 (8390): 1311–1315. PMID 6145023.
- ↑ "Research Enterprise, The 2005 Nobel Prize in Physiology or Medicine". Retrieved 2007-08-26.
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