Leprosy causes: Difference between revisions
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==Cause== | ==Cause== | ||
{{main|Mycobacterium leprae}} | {{main|Mycobacterium leprae}} | ||
''Mycobacterium leprae'' is the causative agent of leprosy.<ref name=Sherris>{{cite book | author = Ryan KJ, Ray CG (editors) | title = Sherris Medical Microbiology | edition = 4th ed. | pages = 451-3 | publisher = McGraw Hill | year = 2004 | isbn = 0838585299}}</ref> An intracellular, [[acid-fast]] [[Bacteria|bacterium]], ''M. leprae'' is [[aerobic]], [[Gram-positive|gram-positive]], and rod-shaped, and is surrounded by the waxy [[cell membrane]] coating characteristic of ''[[Mycobacterium]]'' species.<ref name=Baron>{{cite book | author = McMurray DN | title = Mycobacteria and Nocardia. ''in:'' Baron's Medical Microbiology ''(Baron S ''et al'', eds.)| edition = 4th ed. | publisher = Univ of Texas Medical Branch | year = 1996 | url = http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1833 | isbn = 0-9631172-1-1 }}</ref> | ''Mycobacterium leprae'' is the causative agent of leprosy.<ref name=Sherris>{{cite book | author = Ryan KJ, Ray CG (editors) | title = Sherris Medical Microbiology | edition = 4th ed. | pages = 451-3 | publisher = McGraw Hill | year = 2004 | isbn = 0838585299}}</ref> An intracellular, [[acid-fast]] [[Bacteria|bacterium]], ''M. leprae'' is [[aerobic]], [[Gram-positive|gram-positive]], and rod-shaped, and is surrounded by the waxy [[cell membrane]] coating characteristic of ''[[Mycobacterium]]'' species.<ref name=Baron>{{cite book | author = McMurray DN | title = Mycobacteria and Nocardia. ''in:'' Baron's Medical Microbiology ''(Baron S ''et al'', eds.)| edition = 4th ed. | publisher = Univ of Texas Medical Branch | year = 1996 | url = http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=mmed.section.1833 | isbn = 0-9631172-1-1 }}</ref> | ||
Due to extensive loss of [[gene]]s necessary for independent growth, ''M. leprae'' is [[Microbiological culture|unculturable]] in the laboratory, a factor which leads to difficulty in definitively identifying the organism under a strict interpretation of [[Koch's postulates]].<ref name=Bhattacharya_2002>{{cite journal |author=Bhattacharya S, Vijayalakshmi N, Parija SC |title=Uncultivable bacteria: Implications and recent trends towards identification |journal=Indian journal of medical microbiology |volume=20 |issue=4 |pages=174-7 |year=2002 |pmid=17657065 |url=http://www.ijmm.org/article.asp?issn=0255-0857;year=2002;volume=20;issue=4;spage=174;epage=177;aulast=Bhattacharya}}</ref> The use of non-culture-based techniques such as [[molecular genetics]] has allowed for alternative establishment of causation.<ref name=Bhattacharya_2002 /> | Due to extensive loss of [[gene]]s necessary for independent growth, ''M. leprae'' is [[Microbiological culture|unculturable]] in the laboratory, a factor which leads to difficulty in definitively identifying the organism under a strict interpretation of [[Koch's postulates]].<ref name=Bhattacharya_2002>{{cite journal |author=Bhattacharya S, Vijayalakshmi N, Parija SC |title=Uncultivable bacteria: Implications and recent trends towards identification |journal=Indian journal of medical microbiology |volume=20 |issue=4 |pages=174-7 |year=2002 |pmid=17657065 |url=http://www.ijmm.org/article.asp?issn=0255-0857;year=2002;volume=20;issue=4;spage=174;epage=177;aulast=Bhattacharya}}</ref> The use of non-culture-based techniques such as [[molecular genetics]] has allowed for alternative establishment of causation.<ref name=Bhattacharya_2002 /> | ||
[[Image:M leprae ziehl nielsen2.jpg|thumb|left|''Mycobacterium leprae'', the causative agent of leprosy. As [[acid-fast]] bacteria, ''M. leprae'' appear red when a [[Ziehl-Neelsen stain]] is used.]] {{-}} | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Cause
Mycobacterium leprae is the causative agent of leprosy.[1] An intracellular, acid-fast bacterium, M. leprae is aerobic, gram-positive, and rod-shaped, and is surrounded by the waxy cell membrane coating characteristic of Mycobacterium species.[2]
Due to extensive loss of genes necessary for independent growth, M. leprae is unculturable in the laboratory, a factor which leads to difficulty in definitively identifying the organism under a strict interpretation of Koch's postulates.[3] The use of non-culture-based techniques such as molecular genetics has allowed for alternative establishment of causation.[3]
References
- ↑ Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. pp. 451–3. ISBN 0838585299.
- ↑ McMurray DN (1996). Mycobacteria and Nocardia. in: Baron's Medical Microbiology (Baron S et al, eds.) (4th ed. ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1.
- ↑ 3.0 3.1 Bhattacharya S, Vijayalakshmi N, Parija SC (2002). "Uncultivable bacteria: Implications and recent trends towards identification". Indian journal of medical microbiology. 20 (4): 174–7. PMID 17657065.