Lyme disease natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Prognosis== | |||
For early cases, prompt treatment is usually curative.<ref>{{cite journal |author=Krause PJ, Foley DT, Burke GS, Christianson D, Closter L, Spielman A |title=Reinfection and relapse in early Lyme disease |journal=Am. J. Trop. Med. Hyg. |volume=75 |issue=6 |pages=1090-4 |year=2006 |pmid=17172372}}</ref> However, the severity and treatment of Lyme disease may be complicated due to late diagnosis, failure of antibiotic treatment, simultaneous infection with other tick-borne diseases including [[ehrlichiosis]], [[babesiosis]], and [[bartonella]], and immune suppression in the patient. | |||
A meta-analysis published in 2005 found that some patients with Lyme disease have fatigue, joint and/or muscle pain, and [[neurocognitive]] symptoms persisting for years despite antibiotic treatment.<ref name="Cairns">{{cite journal | author = Cairns V, Godwin J | title = Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms. | journal = Int J Epidemiol | volume = 34 | issue = 6 | pages = 1340-5 | year = 2005 | pmid = 16040645}}</ref> Patients with late Stage Lyme disease have been shown to experience a level of physical [[disability]] equivalent to that seen in [[congestive heart failure]].<ref name="Klempner">{{cite journal | author=Klempner MS, Hu LT, Evans J, ''et al'' | title=Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease | journal=N Engl J Med | year=2001 | pages=85-92 | volume=345 | issue=2 | pmid= 11450676}}</ref> | |||
Though rare, Lyme disease can be fatal.<ref name="Kirsch">{{cite journal | author=Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A | title=Fatal adult respiratory distress syndrome in a patient with Lyme disease | journal=JAMA | year=1988 | pages=2737-9 | volume=259 | issue=18 | pmid= 3357244}}</ref><ref name="Oksi-b">{{cite journal | author=Oksi J, Kalimo H, Marttila RJ, ''et al'' | title=Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature | journal=Brain | year=1996 | pages=2143-54 | volume=119 | issue=Pt 6 | pmid= 9010017}}</ref><ref name="Waniek">{{cite journal | author=Waniek C, Prohovnik I, Kaufman MA, Dwork AJ | title=Rapidly progressive frontal-type dementia associated with Lyme disease | journal=J Neuropsychiatry Clin Neurosci | year=1995 | pages=345-7 | volume=7 | issue=3 | pmid= 7580195}}</ref><ref name="Cary">{{cite journal | author=Cary NR, Fox B, Wright DJ, Cutler SJ, Shapiro LM, Grace AA | title=Fatal Lyme carditis and endodermal heterotopia of the atrioventricular node | journal=Postgrad Med J | year=1990 | pages=134-6 | volume=66 | issue=772 | pmid= 2349186}}</ref>The first CDC recognized death from Lyme disease was Amanda Schmidt, age 11.<ref>{{ cite news | url = http://pqasb.pqarchiver.com/latimes/access/60144819.html?dids=60144819:60144819&FMT=ABS&FMTS=ABS:FT&type=current&date=Sep+26%2C+1990&author=&pub=Los+Angeles+Times+(pre-1997+Fulltext)&edition=&startpage=2&desc=HEALTH+First+Lyme+Disease+Death+Told | title = First Lyme Disease Death Told | work = Los Angeles Times | date = 1990-09-26}}</ref><!-- Need better ref, here --> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Prognosis
For early cases, prompt treatment is usually curative.[1] However, the severity and treatment of Lyme disease may be complicated due to late diagnosis, failure of antibiotic treatment, simultaneous infection with other tick-borne diseases including ehrlichiosis, babesiosis, and bartonella, and immune suppression in the patient.
A meta-analysis published in 2005 found that some patients with Lyme disease have fatigue, joint and/or muscle pain, and neurocognitive symptoms persisting for years despite antibiotic treatment.[2] Patients with late Stage Lyme disease have been shown to experience a level of physical disability equivalent to that seen in congestive heart failure.[3]
Though rare, Lyme disease can be fatal.[4][5][6][7]The first CDC recognized death from Lyme disease was Amanda Schmidt, age 11.[8]
References
- ↑ Krause PJ, Foley DT, Burke GS, Christianson D, Closter L, Spielman A (2006). "Reinfection and relapse in early Lyme disease". Am. J. Trop. Med. Hyg. 75 (6): 1090–4. PMID 17172372.
- ↑ Cairns V, Godwin J (2005). "Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms". Int J Epidemiol. 34 (6): 1340–5. PMID 16040645.
- ↑ Klempner MS, Hu LT, Evans J; et al. (2001). "Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease". N Engl J Med. 345 (2): 85–92. PMID 11450676.
- ↑ Kirsch M, Ruben FL, Steere AC, Duray PH, Norden CW, Winkelstein A (1988). "Fatal adult respiratory distress syndrome in a patient with Lyme disease". JAMA. 259 (18): 2737–9. PMID 3357244.
- ↑ Oksi J, Kalimo H, Marttila RJ; et al. (1996). "Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature". Brain. 119 (Pt 6): 2143–54. PMID 9010017.
- ↑ Waniek C, Prohovnik I, Kaufman MA, Dwork AJ (1995). "Rapidly progressive frontal-type dementia associated with Lyme disease". J Neuropsychiatry Clin Neurosci. 7 (3): 345–7. PMID 7580195.
- ↑ Cary NR, Fox B, Wright DJ, Cutler SJ, Shapiro LM, Grace AA (1990). "Fatal Lyme carditis and endodermal heterotopia of the atrioventricular node". Postgrad Med J. 66 (772): 134–6. PMID 2349186.
- ↑ "First Lyme Disease Death Told". Los Angeles Times. 1990-09-26.