Mononucleosis overview: Difference between revisions
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==Overview== | ==Overview== | ||
'''Infectious mononucleosis''' or mononucleosis also known as '''kissing disease''', or '''Pfeiffer's disease''', in North America as '''mono''' and more commonly known as '''glandular fever''' in other English-speaking countries. It occurs most commonly in [[adolescent]]s and young adults, where it is characterized by [[fever]], sore throat, muscle soreness, and fatigue. Infectious Mononucleosis typically produces a very mild illness in small children, but is usually asymptomatic. Mononucleosis is caused by the [[Epstein-Barr virus]] (EBV), which infects [[B cell]]s (B-lymphocytes), producing a reactive [[lymphocytosis]] and atypical [[T cell]]s (T-lymphocytes) known as Downey bodies. | |||
The name comes because the number of mononuclear leukocytes ([[white blood cells]] with a one-lobed nucleus) rises significantly. There are two main types of mononuclear leukocytes: [[monocyte]]s and [[lymphocyte]]s. Normal [[Reference_ranges_for_blood_tests#Hematology|blood values]] are 35% of all white blood cells. With infectious mononucleosis, this can rise to 50-70%. Also, the total white blood count may increase to 10,000-20,000 per cubic millimeter (normally 4,000-11,000). | |||
==References== | ==References== | ||
Revision as of 21:43, 8 February 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Infectious mononucleosis or mononucleosis also known as kissing disease, or Pfeiffer's disease, in North America as mono and more commonly known as glandular fever in other English-speaking countries. It occurs most commonly in adolescents and young adults, where it is characterized by fever, sore throat, muscle soreness, and fatigue. Infectious Mononucleosis typically produces a very mild illness in small children, but is usually asymptomatic. Mononucleosis is caused by the Epstein-Barr virus (EBV), which infects B cells (B-lymphocytes), producing a reactive lymphocytosis and atypical T cells (T-lymphocytes) known as Downey bodies.
The name comes because the number of mononuclear leukocytes (white blood cells with a one-lobed nucleus) rises significantly. There are two main types of mononuclear leukocytes: monocytes and lymphocytes. Normal blood values are 35% of all white blood cells. With infectious mononucleosis, this can rise to 50-70%. Also, the total white blood count may increase to 10,000-20,000 per cubic millimeter (normally 4,000-11,000).