Gumma (pathology)

Gumma (pathology)
ICD-10	A52.3 A52.7
ICD-9	090.5 094.9 095 102.6
DiseasesDB	30601
MedlinePlus	000859

WikiDoc Resources for Gumma (pathology)
Articles
Most recent articles on Gumma (pathology) Most cited articles on Gumma (pathology) Review articles on Gumma (pathology) Articles on Gumma (pathology) in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Gumma (pathology) Images of Gumma (pathology) Photos of Gumma (pathology) Podcasts & MP3s on Gumma (pathology) Videos on Gumma (pathology)
Evidence Based Medicine
Cochrane Collaboration on Gumma (pathology) Bandolier on Gumma (pathology) TRIP on Gumma (pathology)
Clinical Trials
Ongoing Trials on Gumma (pathology) at Clinical Trials.gov Trial results on Gumma (pathology) Clinical Trials on Gumma (pathology) at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Gumma (pathology) NICE Guidance on Gumma (pathology) NHS PRODIGY Guidance FDA on Gumma (pathology) CDC on Gumma (pathology)
Books
Books on Gumma (pathology)
News
Gumma (pathology) in the news Be alerted to news on Gumma (pathology) News trends on Gumma (pathology)
Commentary
Blogs on Gumma (pathology)
Definitions
Definitions of Gumma (pathology)
Patient Resources / Community
Patient resources on Gumma (pathology) Discussion groups on Gumma (pathology) Patient Handouts on Gumma (pathology) Directions to Hospitals Treating Gumma (pathology) Risk calculators and risk factors for Gumma (pathology)
Healthcare Provider Resources
Symptoms of Gumma (pathology) Causes & Risk Factors for Gumma (pathology) Diagnostic studies for Gumma (pathology) Treatment of Gumma (pathology)
Continuing Medical Education (CME)
CME Programs on Gumma (pathology)
International
Gumma (pathology) en Espanol Gumma (pathology) en Francais
Business
Gumma (pathology) in the Marketplace Patents on Gumma (pathology)
Experimental / Informatics
List of terms related to Gumma (pathology)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

A gumma is a soft, non-cancerous growth resulting from the tertiary stage of syphilis. It is a form of granuloma. Gummas are most commonly found in the liver (gumma hepatis), but can also be found in brain, heart, skin, bone, testis, and other tissues, leading to a variety of potential problems including neurological disorders or heart valve disease.

Syphilitic gummas are found in most but not all cases of tertiary syphilis, and can occur either singly or in groups. Gummas have a firm center that may become partly hyalinized. These central regions begin to die through coagulative necrosis, though they also retain some of the structural characteristics of previously normal tissues, enabling a distinction from the granulomas of tuberculosis where caseous necrosis obliterates preexisting structures. Other histological features of gummas include an intervening zone containing epithelioid cells with indistinct borders and multinucleated giant cells, and a peripheral zone of fibroblasts and capillaries. Inflitration of lymphocytes and plasma cells can be seen in the peripheral zone as well. With time, gummas eventually undergo fibrous degeneration, leaving behind an irregular scar or a round, fibrous nodule.

Related chapters

• Syphilis

Resources

• Medstudent
• Template:GPnotebook