Cellulitis pathophysiology

Cellulitis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Aditya Govindavarjhulla, M.B.B.S.

Overview

Cellulitis results in activation of the body's inflammatory response mechanisms. When the immune system cannot respond adequately, it can spread systemically through the blood stream.

Pathophysiology

Microorganisms gain initial access into the layers of the skin through the discontinuities or cuts in the skin. The body responds to these microbes as a foreign bodies, and this causes an inflammatory response. This leads to redness, swelling, pain and itching of the area involved. A local infection leads to inflammation of the area. With a competent immune system, the spread of the infection is limited. If the immune system fails to curb the infection it may become systemic by spreading into the adjacent areas and may finally enter the blood stream causing (Bacteremia).