Leg pain

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Complete Differential Diagnosis of the causes of Leg pain

(By organ system)

Cardiovascular	Aortoiliac occlusive disease,Cholesterol Emboli Syndrome,Deep Vein Thrombosis,Peripheral Arterial Disease,Thrombophlebitis,Varicose veins
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Abatacept Injection,Acebutolol,Acitretin,Aldesleukin,Alendronate,Allopurinol,Amikacin Sulfate Injection,Anagrelide,Anastrozole,Aripiprazole,Atazanavir,Atenolol,Atorvastatin,Bevacizumab Injection,Bortezomib,Buspirone,Capecitabine,Celecoxib,Celiac disease,Clofarabine Injection,Clonazepam,Clopidogrel,Cortisol,Darbepoetin Alfa,Docetaxel,Epoetin Alfa Injection,Ethacrynic Acid,Etidronate,Ezetimibe,Fenofibrate,Filgrastim,Fluvastatin,Gabapentin,Galantamine,Glatiramer Injection,Ibandronate,Iloprost,Imatinib,Infliximab Injection,Interferon Alfa-2a and Alfa-2b Injection,Interferon Alfacon-1 Injection,Interferon beta-1a Intramuscular Injection,Interferon Beta-1b Injection,Interferon Gamma-1b Injection,Lamivudine,Latanoprost,Leflunomide,Letrozole,Leuprolide,Lovastatin,Methimazole,Methylergonovine,Methylprednisolone,Mifepristone,Natalizumab injection ,Ofloxacin ,Paclitaxel,Peginterferon alfa-2a,Prednisone,Pyrazinamide,Quinupristin dalfopristin,Ribavirin,Rofecoxib,Rosiglitazone,Rosuvastatin,Sunitinib ,Tadalafil ,Tamsulosin ,Telbivudine ,Temozolomide ,Terbutaline,Teriparatide,Tiotropium,Torsemide,Valganciclovir,Valsartan,Vancomycin,Vinblastine,Vincristine,Zalcitabine,Ziprasidone,Zolmitriptan,Zolpidem,
Ear Nose Throat	No underlying causes
Endocrine	Hyperparathyroidism,Primary hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	No underlying causes
Genetic	Fairbanks disease,Familial Mediterranean fever,Mitochondrial trifunctional protein deficiency,Osteogenesis imperfecta
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	No underlying causes
Neurologic	No underlying causes
Nutritional / Metabolic	Acute Intermittent Porphyria,Farber disease,Glycogen storage disease type V,Hypercalcemia,Mucopolysaccharidosis,Osteomalacia
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Ewing's sarcoma,Giant cell tumor of bone,Osteochondroma,Osteoma,Osteosarcoma
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	Pain disorder
Pulmonary	No underlying causes
Renal / Electrolyte	Hypercalcemia
Rheum / Immune / Allergy	Rheumatology : Ankylosing Spondylitis,Behect's disease,Caplan's Syndrome,Fibromyalgia,Osteoarthritis,Osteoporosis,Polymyalgia Rheumatica,Rheumatoid arthritis,Still's disease, Gout Immunology : Systemic lupus erythematosus,Ulcerative colitis,Vasculitis,Graft-versus-host disease,Familial Mediterranean fever
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Phantom pain

In alphabetical order:

• Arterial thromboembolism
• Arthritis
• Autoimmune vascular disorders such as vasculitis
• Baker's cyst
• Cholesterol embolism
• Chronic venous insufficiency
• Connective tissue disease
• Coxsackie B
• Deep Vein Thrombosis (DVT)
• Drugs, toxins
• Hypocalcemia
• Hypokalemia
• Hyponatremia
• Leptospirosis
• Ligament damage
• Lumbar canal stenosis or spinal stenosis
• Muscle or tendon strain
• Night cramps
• Obliterating endarteritis
• Peripheral neuropathy
• Peripheral vascular disease
• Plexopathy
• Primary varicosis
• Radiculopathy
• Restless Leg Syndrome
• Venous thromboembolism (VTE)

References

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