Lorcaserin: Difference between revisions
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==Overview== | ==Overview== | ||
Lorcaserin is a weight-loss drug developed by Arena Pharmaceuticals. It has [[serotonergic]] properties and acts as an [[anorectic]]. On 27 June 2012, the [[Food and Drug Administration|FDA]] officially approved lorcaserin for use in the treatment of [[obesity]] for adults with a [[BMI]] equal to or greater than 30 or adults with a BMI of 27 or greater who "have at least one weight-related health condition, such as high [[blood pressure]], [[type 2 diabetes]], or high [[cholesterol]]". | Lorcaserin is a weight-loss drug developed by Arena Pharmaceuticals. It has [[serotonergic]] properties and acts as an [[anorectic]]. On 27 June 2012, the [[Food and Drug Administration|FDA]] officially approved lorcaserin for use in the treatment of [[obesity]] for adults with a [[BMI]] equal to or greater than 30 or adults with a BMI of 27 or greater who "have at least one weight-related health condition, such as high [[blood pressure]], [[type 2 diabetes]], or high [[cholesterol]]". | ||
Revision as of 14:32, 28 June 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Ujjwal Rastogi, M.B.B.S. [2]
Overview
Lorcaserin is a weight-loss drug developed by Arena Pharmaceuticals. It has serotonergic properties and acts as an anorectic. On 27 June 2012, the FDA officially approved lorcaserin for use in the treatment of obesity for adults with a BMI equal to or greater than 30 or adults with a BMI of 27 or greater who "have at least one weight-related health condition, such as high blood pressure, type 2 diabetes, or high cholesterol".
Mechanism of action
Lorcaserin is a selective 5-HT2C receptor agonist and in vitro testing of the drug showed reasonable selectivity for 5-HT2C over other related targets.
5-HT2C receptors are located almost exclusively in the brain, and can also be found in the choroid plexus, cortex, hippocampus, cerebellum, amygdala, thalamus, and hypothalamus.
The activation of 5-HT2C receptors in the hypothalamus is supposed to activate proopiomelanocortin (POMC) production and consequently promote weight loss through satiety. This hypothesis is supported by clinical trials and other studies.
Side effects
Lorcaserin was approximately as tolerable as placebo in Phase III, with 7% of participants in both the lorcaserin drug and placebo arms dropping out due to side effects.
The side effects noted with the drug compared to placebo are as follows:
| Side effects | Placebo (%) | Drug arm (%) |
|---|---|---|
| Headache (most common) | 11 | 18 |
| Upper respiratory tract infection | 11.9 | 14.8 |
| Nasopharyngitis | 12.0 | 13.4 |
| Nausea | 5.4 | 7.5 |