Growth failure

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Overview

Growth failure is a medical term for a pattern of a child's growth which is poorer than normal for age, sex, stage of maturation, and genetic height expectation. In general it refers to;

• A slow growth velocity, and
• Stunted growth

Growth failure usually has an abnormal cause or causes. Many short children are growing normally and this is not referred to as growth failure.

Linear growth is measured by change of recumbent length in infants until age 2 to 3 years, when a child's height can be measured standing.

Growth failure is a term used to describe failure to grow in length. Growth is a dynamic process that starts before a child is born and continues until the bones fuse after puberty. After puberty, bones continue to mature to achieve prime bone density.Growth in length per year is age dependent and may be affected by many different factors including, but not limited to; hormonal abnormalities, chronic illness, and genetic abnormalities. Failure to grow should be taken seriously as it may indicate a hidden illness, a pediatrician should be consulted if a child is exhibiting slow growth outside of the ranges shown below. All ranges described are averages for the age range. In addition, to rate of growth,the position of the child on the growth chart (which compares other children of the same age) should be observed.

Doctors and families can follow the progress of the children to make sure that they are achieving their appropriate potential.

Differential Diagnosis

Organ system based

Cardiovascular	Atrioventricular septal defect , BlandGarlandWhite syndrome , Congenital heart disease, Cor Triatriatum , Double outlet right ventricle , Endocardial fibroelastosis , Fallot's tetralogy, Patent ductus arteriosus, Transposition of great arteries , Ventricular septal defect
Chemical / poisoning	Lead poisoning
Dermatologic	Leiner Disease
Drug Side Effect	Fetal Hydantoin Syndrome , Fetal thalidomide syndrome , Fetal warfarin syndrome , Prednisolone
Ear Nose Throat	No underlying causes
Endocrine	Adiposogenital dystrophy, Adrenal hyperplasia, congenital type 3 , Adrenomyodystrophy , C21hydroxylase deficiency, Cushing's syndrome , Cystic fibrosis , Diabetes mellitus, Glucocorticoid deficiency, Growth hormone deficiency, Hyperthyroidism, Hypoaldosteronism, Hypopituitarism , Hypothyroidism, KaplowitzBodurtha syndrome , Pseudohypoparathyroidism , Thyroid disease
Environmental	Lead poisoning
Gastroenterologic	Autoimmune enteropathy , Baber's syndrome , Bile acid synthesis defects , Blind loop syndrome , Chronic diarrhoea, Congenital short bowel , Congenital Vitamin B12 Malabsorption , Glucosegalactose malabsorption , Hirschsprung's disease , Malabsorption syndrome, Microvillus Inclusion Disease , Pseudoobstruction idiopathic intestinal
Genetic	14q+ syndrome , 18Hydroxylase deficiency , 18p minus syndrome , 1q deletion , 2q deletion , 3M syndrome , 3q deletion , 49,XXXXX syndrome , 4p16.3 deletion , Aarskog syndrome , Aase syndrome, Abetalipoproteinaemia, ACAD8 deficiency , Adiposogenital dystrophy, Alagille Syndrome , AlbersSchonberg disease , Albright's hereditary osteodystrophy , AlphaLiduronidase deficiency, Alport Syndrome , Alports syndrome, Alsing syndrome , Aminomethyltransferase deficiency, Andersen disease , Anorexia nervosa, Arginase deficiency , Aspartoacylase deficiency, BardetBiedl syndrome, Barth syndrome , Bloom's syndrome, BonnetDechaumeBlanc syndrome, BowenConradi syndrome , BRESHECK syndrome, Byler Disease , CAH, CAMFAK syndrome , Campomelic dwarfism , Carnitine transporter deficiency , Carnosinase deficiency , Carpenter syndrome , CHARGE syndrome, Chromosome 1 uniparental disomy 1q12 q21 , Chromosome 10 ring syndrome , Chromosome 10, distal trisomy 10q , Chromosome 10p deletion syndrome , Chromosome 11q duplication syndrome , Chromosome 12 ring syndrome , Chromosome 12p deletion , Chromosome 13 ring syndrome , Chromosome 13 trisomy syndrome , Chromosome 14 Ring , Chromosome 14 trisomy , Chromosome 15 trisomy , Chromosome 16p, partial duplication , Chromosome 17 ring , Chromosome 18 Ring , Chromosome 19 ring syndrome , Chromosome 1p deletion syndrome , Chromosome 2 trisomy syndrome , Chromosome 20 ring , Chromosome 20p deletion syndrome , Chromosome 21 monosomy , Chromosome 22, trisomy , Chromosome 2p deletion syndrome , Chromosome 2p duplication syndrome , Chromosome 3, trisomy 3p , Chromosome 3, trisomy 3q , Chromosome 4 Ring , Chromosome 4 ring syndrome , Chromosome 5, trisomy 5q , Chromosome 5p duplication syndrome , Chromosome 5p tetrasomy syndrome , Chromosome 6 ring syndrome , Chromosome 6, monosomy 6q , Chromosome 6, trisomy 6q , Chromosome 7 ring syndrome , Chromosome 8 recombinant syndrome , Chromosome 9 trisomy syndrome , Chromosome 9, trisomy , Classic galactosemia , Cleft palate, Cockayne syndrome, CoffinLowry syndrome, Cohen Syndrome , Complement 5 deficiency, Complete Trisomy 18 syndrome , Complex 5 mitochondrial respiratory chain deficiency , Congenital chloride diarrhea , ConradiHuenermann Syndrome , Corpus callosum agenesis , Criduchat syndrome , De Barsy syndrome, DiamondBlackfan anemia , DiGeorge syndrome , Down syndrome, Edward Syndrome , Faciocardiorenal syndrome, Fallot's tetralogy, Farber's disease , Filippi syndrome, Forbes disease , Francois dyscephalic syndrome , Fucosidosis, Galactosemia , GAPO syndrome , Glucosegalactose malabsorption , HoyeraalHreidarsson syndrome , ICF syndrome , Iduronate sulphatase deficiency, Inborn amino acid metabolism disorder , Inborn urea cycle disorder , Infantile dysphagia , Infantile hypophosphatasia , Infantile Refsum Disease , IPEX syndrome , Ivemark Syndrome , Jeune's thoracic dystrophy syndrome, JirasekZuelzerWilson syndrome , JohansonBlizzard syndrome, JubergMarsidi syndrome , Kabuki makeup syndrome, Kartagener's syndrome, KennyCaffeyLinarelli syndrome, Kowarski syndrome , Leigh syndrome , Leprechaunism, LeriWeill dyschondrosteosis, Lissencephaly , Lissencephaly, Lowe oculocerebrorenal syndrome , Lowe Syndrome , LutzRichnerLandolt syndrome , Maple syrup urine disease, MardenWalker syndrome, Martsolf syndrome, Menkes Disease , Miescher's syndrome , Mitochondrial diseases, MULIBREY Nanism , Multiple lentigines syndrome, Navajo neurohepatopathy , Neuronal Migration Disorders , Nezelof Syndrome , NiemannPick disease , NOMID syndrome , Omenn syndrome , Opitz trigonocephaly syndrome, Osteogenesis imperfecta, Otopalatodigital syndrome, Pearson's anemia , PelizaeusMerzbacher disease, Phenylketonuria , Pierre Robin's sequence , PittRogersDanks syndrome, Pompe disease , PowellBuistStenzel syndrome , PraderWilli syndrome , Progeroid syndrome, Progressive familial intrahepatic cholestasis, RussellSilver dwarfism, SaethreChotzen Syndrome , SCID , Seckle syndrome , Sheffield syndrome , ShwachmanDiamond Syndrome , Sickle Cell Anemia , Silver's syndrome, SingletonMerten Syndrome , TaySachs disease, Thyroid agenesis , Transposition of great arteries , Trisomy 18 Syndrome , Turner syndrome , Tyrosinemia , VATER association , Velocardiofacial syndrome, Von Gierke disease , WAGR Syndrome , Watson syndrome , Williams syndrome, Wittwer sydnrome , WolcottRallison syndrome , YunisVaron syndrome, ZAP70 deficiency
Hematologic	No underlying causes
Iatrogenic	No underlying causes
Infectious Disease	No underlying causes
Musculoskeletal / Ortho	No underlying causes
Neurologic	No underlying causes
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	No underlying causes
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal / Electrolyte	No underlying causes
Rheum / Immune / Allergy	No underlying causes
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	No underlying causes

In alphabetical order

• Achondroplasia
• Crohn's Disease
• Congenital adrenal hyperplasia
• Constitutional delay
• Cushing's Disease
• Cushing's Syndrome
• Cyanotic heart disease
• Cystic Fibrosis
• Dermatomyositis
• Down's Syndrome
• Exogenous androgen
• Familial short stature
• Gluten enteropathy
• Growth hormone deficiency
• Growth hormone insensitivity
• Hypochondroplasia
• Hypothyroidism
• Intrauterine growth retardation
• Malnutrition
• Microcephaly
• Noonan Syndrome
• Prader-Willi Syndrome
• Precocious puberty
• Psychosocial dwarfism
• Renal Tubular Acidosis
• Russell-Silver Syndrome
• Turner's Syndrome
• Ulcerative Colitis

External Links

• MAGIC Foundation for Children's Growth

See also

• Failure to thrive
• Short stature
• Dwarfism