Easy bruising

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Raviteja Guddeti, M.B.B.S. [2]

Complete Differential Diagnosis of the Causes of Easy bruising

Common causes

• Acute lymphoblastic leukemia

• Acute myeloid leukemia

• Aging

• Aspirin

• Chronic lymphocytic leukemia

• Chronic myelogenous leukemia

• Chronic renal insufficiency

• Chronic viral hepatitis

• Cirrhosis

• Dengue Fever

• Factor VII deficiency

• Factor V deficiency

• Hemophilia A

• Hemophilia B

• Liver disease

• Malnutrition

• NSAIDs

• Sepsis

• Steroid use

• Thrombocytopenia

• Von Willebrand's Disease

Causes by Organ system

Cardiovascular	Cardiac cirrhosis
Chemical / poisoning	Brodifacoum, Chlorophacinone rodenticide poisoning, Coumachlor rodenticide poisoning, Coumafuryl rodenticide poisoning, Coumatetralyl rodenticide poisoning, Difenacoum rodenticide poisoning, Difethialone rodenticide poisoning, Diphacinone rodenticide poisoning, Finale rodenticide poisoning, Flocoumafen rodenticide poisoning, Folgorat rodenticide poisoning, Havoc rodenticide poisoning, Indandione rodenticide poisoning, Klerat rodenticide poisoning, Matikus rodenticide poisoning, Mouser rodenticide poisoning, Pindone rodenticide poisoning, Ratak Plus rodenticide poisoning, Rodend rodenticide poisoning, Talon rodenticide poisoning, Volak rodenticide poisoning, Volid rodenticide poisoning
Dermatologic	Epidermolysis bullosa simplex - Ogna type, Henoch-Schonlein purpura, Hermansky-Pudlak Syndrome, Lichen Sclerosus, Wiskott-Aldrich Syndrome
Drug Side Effect	Amino salicylic acid, Anticoagulant (Warfarin), Aspirin, Bromadiolone, Entacapone, Filgrastim, Imatinib, Isotretinoin, Lenograstim, NSAIDs, Pentoxifylline, Phenylbutazone, prednisone, Sodium aurothiomalate (Myocrisin Injection 2%), Steroid, Zonisamide
Ear Nose Throat	No underlying causes
Endocrine	Alcohol-induced pseudo-Cushing syndrome, Cushing's syndrome, Graves Disease, Schroeder syndrome 1
Environmental	Caterpillar-induced bleeding syndrome, Solar skin exposure
Gastroenterologic	Biliary atresia, Cirrhosis, Cryptogenic cirrhosis, Hemochromatosis, Hypersplenism, Liver disease, Nonalcoholic fatty liver disease , Primary biliary cirrhosis , Primary sclerosing cholangitis, Secondary Biliary Cirrhosis, Wilson's disease, Cardiac cirrhosis, Chronic viral hepatitis, Autoimmune hepatitis, Henoch-Schonlein purpura
Genetic	Down syndrome (Acute lymphoblastic leukemia), Hereditary macrothrombocytopenia, May-Hegglin Anomaly,Osteogenesis imperfecta Type I, Osteogenesis imperfecta type IV, Owren Parahemophilia, Glanzmann Thrombasthenia, Familial Hemophagocytic lymphohistiocytosis, Hemophilia A, Hemophilia B, Hermansky-Pudlak Syndrome, Von Willebrand's Disease, Marfan Syndrome, Wiskott-Aldrich Syndrome, X-linked dyserythropoietic anaemia and thrombocytopenia
Hematologic	Anti-factor VIIIc syndrome, ATRUS syndrome, Acute leukaemia of ambiguous lineage, Acquired amegakaryocytic thrombocytopenia, Acquired hypoprothrombinemia, Acquired pure megakaryocytic aplasia, Acute biphenotypic leukemia, Acute erythroleukemia, Acute lymphoblastic leukemia, Acute megacaryoblastic leukemia, Acute myelocytic leukemia, Acute myeloid leukemia, Acute non lymphoblastic leukemia, Acute promyelocytic leukemia, Deficiency of ADP platelet receptor P2Y12, Congenital Anti-plasmin deficiency, Aplastic anemia, Bernard-Soulier Syndrome, Chronic Idiopathic Myelofibrosis, Chronic lymphocytic leukemia, Chronic myelogenous leukemia, Chronic myeloid leukemia, Chronic myelomonocytic leukemia, Myeloproliferative Disorders, Chronic Neutrophilic Leukemia, Familial CML-Like Syndrome, Congenital amegakaryocytic thrombocytopenia, DIC, Essential thrombocytopenia, Essential thrombocytosis, Factor IX Deficiency, Combined deficiency of Factor V and factor VIII, Factor V deficiency, Factor VII deficiency, Factor X deficiency, Familial platelet syndrome with predisposition to acute myelogenous leukemia, Glanzmann Thrombasthenia, Hairy cell leukemia, Familial Hemophagocytic lymphohistiocytosis, Hemophilia A, Hemophilia B, Hereditary macrothrombocytopenia, Immune thrombocytopenic purpura, Idiopathic thrombocytopenic purpura, Chronic T-cell leukemia, Lymphoblastic lymphoma, Multiple myeloma, Myelofibrosis,Myelogenous leukemia, Pancytopenia, Paroxysmal Nocturnal Hemoglobinuria, Prothrombin deficiency, Storage pool platelet disease, Stuart factor deficiency, T-cell acute lymphoblastic leukemia, Thrombasthenia, Thrombocytopathy, Thrombocytopenia -- cerebellar hypoplasia -- short stature, Thrombocytopenia, Von Willebrand's Disease, Waldenstrom macroglobulinemia, Retinopathy -- aplastic anemia -- neurological abnormalities, May-Hegglin Anomaly, Owren Parahemophilia, X-linked dyserythropoietic anaemia and thrombocytopenia, Wiskott-Aldrich Syndrome
Iatrogenic	No underlying causes
Infectious Disease	Chronic viral hepatitis, Dengue Fever, Human T-lymphotropic virus type 3, Sepsis
Musculoskeletal / Ortho	ATRUS syndrome, Ehlers-Danlos syndrome, Marfan Syndrome, Osteogenesis imperfecta Type I, Osteogenesis imperfecta type IV, Henoch-Schonlein purpura, Spondylometaphyseal dysplasia with combined immunodeficiency
Neurologic	Wilson's disease, Thrombocytopenia -- cerebellar hypoplasia -- short stature, Chediak-Higashi Syndrome, Retinopathy -- aplastic anemia -- neurological abnormalities
Nutritional / Metabolic	B12 deficiency, Folate deficiency, Gaucher Disease, Glycogen Storage Disease Type I, Malnutrition, Niemann-Pick disease, Sphingolipidosis, Thiopurine S methyltranferase deficiency, Von Gierke Disease, Xylosylprotein 4-beta-galactosyltransferase (XGPT) deficiency
Obstetric/Gynecologic	Eclampsia, HELLP syndrome
Oncologic	Acute biphenotypic leukemia, Acute erythroleukemia, Acute lymphoblastic leukemia, Acute megacaryoblastic leukemia, Acute myelocytic leukemia, Acute myeloid leukemia, Acute non lymphoblastic leukemia, Acute promyelocytic leukemia, Chronic lymphocytic leukemia, Chronic myelogenous leukemia, Chronic myeloid leukemia, Chronic myelomonocytic leukemia, Chronic Neutrophilic Leukemia, Hairy cell leukemia, Chronic T-cell leukemia, Lymphoblastic lymphoma, Multiple myeloma, Myelogenous leukemia, T-cell acute lymphoblastic leukemia
Opthalmologic	Retinopathy -- aplastic anemia -- neurological abnormalities
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal / Electrolyte	Chronic renal insufficiency, Fanconi syndrome, Renal failure, Henoch-Schonlein purpura
Rheum / Immune / Allergy	Autoimmune hepatitis, Chediak-Higashi Syndrome, Immune thrombocytopenic purpura, Systemic Lupus Erythematosus, Primary biliary cirrhosis , Primary sclerosing cholangitis, Glanzmann Thrombasthenia, Wiskott-Aldrich Syndrome
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Aging, Amyloidosis, Normal - especially in females

Causes by Alphabetical order

Anti-factor VIIIc syndrome Acquired amegakaryocytic thrombocytopenia Acquired hypoprothrombinemia Acquired pure megakaryocytic aplasia Acute biphenotypic leukemia Acute erythroleukemia Acute leukaemia of ambiguous lineage Acute lymphoblastic leukemia Acute megacaryoblastic leukemia Acute myelocytic leukemia Acute myeloid leukemia Acute non lymphoblastic leukemia Acute promyelocytic leukemia Aging Alcohol-induced pseudo-Cushing syndrome Amino salicylic acid Amyloidosis Anticoagulant (Warfarin) Aplastic anemia Aspirin ATRUS syndrome Autoimmune hepatitis B12 deficiency Bernard-Soulier Syndrome Biliary atresia Brodifacoum Bromadiolone Cardiac cirrhosis Caterpillar-induced bleeding syndrome Chediak-Higashi Syndrome Chlorophacinone rodenticide poisoning Chronic T-cell leukemia Chronic Idiopathic Myelofibrosis Chronic lymphocytic leukemia Chronic myelogenous leukemia Chronic myeloid leukemia Chronic myelomonocytic leukemia Chronic Neutrophilic Leukemia Chronic renal insufficiency Chronic viral hepatitis Cirrhosis Combined deficiency of Factor V and factor VIII Congenital amegakaryocytic thrombocytopenia Congenital Anti-plasmin deficiency Coumachlor rodenticide poisoning Coumafuryl rodenticide poisoning Coumatetralyl rodenticide poisoning Cryptogenic cirrhosis Cushing's syndrome Deficiency of ADP platelet receptor P2Y12 Dengue Fever DIC Difenacoum rodenticide poisoning Difethialone rodenticide poisoning

Diphacinone rodenticide poisoning Down syndrome (Acute lymphoblastic leukemia) Eclampsia Ehlers-Danlos syndrome Entacapone Epidermolysis bullosa simplex - Ogna type Essential thrombocytopenia Essential thrombocytosis Factor IX Deficiency Factor V deficiency Factor VII deficiency Factor X deficiency Familial CML-Like Syndrome Familial Hemophagocytic lymphohistiocytosis Familial platelet syndrome with predisposition to acute myelogenous leukemia Fanconi syndrome Filgrastim Finale rodenticide poisoning Flocoumafen rodenticide poisoning Folate deficiency Folgorat rodenticide poisoning Gaucher Disease Glanzmann Thrombasthenia Glycogen Storage Disease Type I Graves Disease Hairy cell leukemia Havoc rodenticide poisoning HELLP syndrome Hemochromatosis Hemophilia A Hemophilia B Henoch-Schonlein purpura Hereditary macrothrombocytopenia Hermansky-Pudlak Syndrome Human T-lymphotropic virus type 3 Hypersplenism Idiopathic thrombocytopenic purpura Imatinib Immune thrombocytopenic purpura Indandione rodenticide poisoning Isotretinoin Klerat rodenticide poisoning Lenograstim Lichen Sclerosus Liver disease Lymphoblastic lymphoma Malignancy Malnutrition Marfan Syndrome Matikus rodenticide poisoning May-Hegglin Anomaly Mouser rodenticide poisoning Multiple myeloma

Myelofibrosis Myelogenous leukemia Myeloproliferative Disorders Niemann-Pick disease Nonalcoholic fatty liver disease Normal - especially in females NSAIDs Osteogenesis imperfecta Type I Osteogenesis imperfecta type IV Owren Parahemophilia Pancytopenia Paroxysmal Nocturnal Hemoglobinuria Pentoxifylline Phenylbutazone Pindone rodenticide poisoning prednisone Primary biliary cirrhosis Primary sclerosing cholangitis Prothrombin deficiency Ratak Plus rodenticide poisoning Renal failure Retinopathy -- aplastic anemia -- neurological abnormalities Rodend rodenticide poisoning Schroeder syndrome 1 Secondary Biliary Cirrhosis Sepsis Sodium aurothiomalate (Myocrisin Injection 2% Solar skin exposure Sphingolipidosis Spondylometaphyseal dysplasia with combined immunodeficiency Steroid Storage pool platelet disease Stuart factor deficiency Systemic Lupus Erythematosus Talon rodenticide poisoning T-cell acute lymphoblastic leukemia Thiopurine S methyltranferase deficiency Thrombasthenia Thrombocytopathy Thrombocytopenia -- cerebellar hypoplasia -- short stature Thrombocytopenia Volak rodenticide poisoning Volid rodenticide poisoning Von Gierke Disease Von Willebrand's Disease Waldenstrom macroglobulinemia Wilson's disease Wiskott-Aldrich Syndrome X-linked dyserythropoietic anaemia and thrombocytopenia Xylosylprotein 4-beta-galactosyltransferase (XGPT) deficiency Zonisamide