Reticulum cell sarcoma: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
The dominant cell type is thought to be derived from [[histiocytes]] or [[macrophages]]. More recent thinking indicates that this cancer may arise from [[lymphocytes]] or [[immunoblasts]]. | The dominant cell type is thought to be derived from [[histiocytes]] or [[macrophages]]. More recent thinking indicates that this cancer may arise from [[lymphocytes]] or [[immunoblasts]]. | ||
==Disorders to Distinguish Reticulum Cell Sarcoma From== | |||
[[Ewing's sarcoma]] | |||
[[Fibrosarcoma]] | |||
[[Metastatic carcinoma]] | |||
[[Osteomyelitis]] | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
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*Effusion of adjacent joint | *Effusion of adjacent joint | ||
===Imaging Findings=== | |||
*Osteolytic lesions with minimal periosteal reactions are present on plain films of the bone | *Osteolytic lesions with minimal periosteal reactions are present on plain films of the bone | ||
Revision as of 23:02, 15 July 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Keywords and synonyms: histiocytic lymphoma, histiocytic lymphosarcoma
Overview
A malignant tumor of reticular tissue in the bone that is composed primarily of neoplastic histocytes.
Pathophysiology
The dominant cell type is thought to be derived from histiocytes or macrophages. More recent thinking indicates that this cancer may arise from lymphocytes or immunoblasts.
Disorders to Distinguish Reticulum Cell Sarcoma From
Ewing's sarcoma Fibrosarcoma Metastatic carcinoma Osteomyelitis
Epidemiology and Demographics
- Presents in middle age
Diagnosis
Symptoms
- Localized bone pain and tenderness
Physical Examination
- Tenderness of bone
- Effusion of adjacent joint
Imaging Findings
- Osteolytic lesions with minimal periosteal reactions are present on plain films of the bone
Pathology
- Large, foam filled histiocytes with numerous mitoses and scant stroma are present
- Stains for reticulum are positive
- Periodic Acid Schiff (PAS) stains are negative
Treatment
Early stage I tumors
- Radiation therapy alone
Advanced Tumors