Cerebral venous sinus thrombosis natural history: Difference between revisions
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In 2004 the first adequately large scale study on the natural history and long-term prognosis of this condition was reported and showed that at 16 months followup: 57.1% of patients had full recovery, 29.5%/2.9%/2.2% had respectively minor/moderate/severe symptoms or impairments, and 8.3% had died. Severe impairment or death were more likely in those aged over 37 years, male, affected by coma, mental status disorder, intracerebral hemorrhage, thrombosis of the deep cerebral venous system, central nervous system infection and cancer.<ref name="pmid14976332">{{cite journal |author=Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F |title=Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) |journal=Stroke |volume=35 |issue=3 |pages=664–70 |year=2004 |pmid=14976332 |doi=10.1161/01.STR.0000117571.76197.26 |url=http://stroke.ahajournals.org/cgi/content/full/35/3/664}}</ref> A subsequent [[systematic review]] of nineteen studies in 2006 showed that mortality is about 5.6% during hospitalisation and 9.4% in total, while of the survivors 88% make a total or near-total recovery. After several months, two thirds of the cases has resolution ("recanalisation") of the clot. The rate of recurrence was low (2.8%).<ref>{{cite journal |author=Dentali F, Gianni M, Crowther MA, Ageno W |title=Natural history of cerebral vein thrombosis: a systematic review |journal=Blood |volume=108 |issue=4 |pages=1129–34 |year=2006 |pmid=16609071 |doi=10.1182/blood-2005-12-4795}}</ref> | In 2004 the first adequately large scale study on the natural history and long-term prognosis of this condition was reported and showed that at 16 months followup: 57.1% of patients had full recovery, 29.5%/2.9%/2.2% had respectively minor/moderate/severe symptoms or impairments, and 8.3% had died. Severe impairment or death were more likely in those aged over 37 years, male, affected by coma, mental status disorder, intracerebral hemorrhage, thrombosis of the deep cerebral venous system, central nervous system infection and cancer.<ref name="pmid14976332">{{cite journal |author=Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F |title=Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) |journal=Stroke |volume=35 |issue=3 |pages=664–70 |year=2004 |pmid=14976332 |doi=10.1161/01.STR.0000117571.76197.26 |url=http://stroke.ahajournals.org/cgi/content/full/35/3/664}}</ref> A subsequent [[systematic review]] of nineteen studies in 2006 showed that mortality is about 5.6% during hospitalisation and 9.4% in total, while of the survivors 88% make a total or near-total recovery. After several months, two thirds of the cases has resolution ("recanalisation") of the clot. The rate of recurrence was low (2.8%).<ref>{{cite journal |author=Dentali F, Gianni M, Crowther MA, Ageno W |title=Natural history of cerebral vein thrombosis: a systematic review |journal=Blood |volume=108 |issue=4 |pages=1129–34 |year=2006 |pmid=16609071 |doi=10.1182/blood-2005-12-4795}}</ref> | ||
==References== | |||
{{Reflist|2}} | {{Reflist|2}} | ||
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In 2004 the first adequately large scale study on the natural history and long-term prognosis of this condition was reported and showed that at 16 months followup: 57.1% of patients had full recovery, 29.5%/2.9%/2.2% had respectively minor/moderate/severe symptoms or impairments, and 8.3% had died. Severe impairment or death were more likely in those aged over 37 years, male, affected by coma, mental status disorder, intracerebral hemorrhage, thrombosis of the deep cerebral venous system, central nervous system infection and cancer.[1] A subsequent systematic review of nineteen studies in 2006 showed that mortality is about 5.6% during hospitalisation and 9.4% in total, while of the survivors 88% make a total or near-total recovery. After several months, two thirds of the cases has resolution ("recanalisation") of the clot. The rate of recurrence was low (2.8%).[2]
References
- ↑ Ferro JM, Canhão P, Stam J, Bousser MG, Barinagarrementeria F (2004). "Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT)". Stroke. 35 (3): 664–70. doi:10.1161/01.STR.0000117571.76197.26. PMID 14976332.
- ↑ Dentali F, Gianni M, Crowther MA, Ageno W (2006). "Natural history of cerebral vein thrombosis: a systematic review". Blood. 108 (4): 1129–34. doi:10.1182/blood-2005-12-4795. PMID 16609071.