Adrenocortical carcinoma natural history: Difference between revisions
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{{CMG}}; {{AE}} {{RT}} | {{CMG}}; {{AE}} {{RT}} | ||
==Complications== | ==Complications== | ||
The following are the complications of [[Adrenocortical carcinoma]]: | |||
* [[Cushing's syndrome]] | * [[Cushing's syndrome]] | ||
* [[Conn syndrome]] | * [[Conn syndrome]] | ||
* [[Hypertension]] | * [[Hypertension]] | ||
* [[Virilization]] | * [[Virilization]] | ||
* [[Feminization]] | * [[Feminization]] | ||
* Local metastasis and tumor [[thrombus]] formation | * Local metastasis and tumor [[thrombus]] formation | ||
* [[Paraneoplastic syndrome]] | * [[Paraneoplastic syndrome]] | ||
* Distant [[metastasis]] | * Distant [[metastasis]] | ||
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and is unlike most tumours of the adrenal cortex, which are [[benign]] ([[adenoma]]s) and only occasionally cause [[Cushing's syndrome]]. Five-year disease-free survival for a complete resection of a [[Cancer staging|stage]] I-III ACC is approximately 30%.<ref name=allolio/> | and is unlike most tumours of the adrenal cortex, which are [[benign]] ([[adenoma]]s) and only occasionally cause [[Cushing's syndrome]]. Five-year disease-free survival for a complete resection of a [[Cancer staging|stage]] I-III ACC is approximately 30%.<ref name=allolio/> | ||
The most important '''prognostic factors''' are: | The most important '''prognostic factors''' are: | ||
* Age of the patient. | |||
* Stage of the tumor. | |||
Poor prognostic factors: | Poor prognostic factors: | ||
* Mitotic activity. | |||
* Venous invasion. | |||
* Weight more than 50 Kg. | |||
* Diameter more than 6.5 cm. | |||
* Ki-67/MIB1 labeling index. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 08:36, 29 July 2012
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Adrenocortical carcinoma Microchapters |
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Differentiating Adrenocortical carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Study |
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Adrenocortical carcinoma natural history On the Web |
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American Roentgen Ray Society Images of Adrenocortical carcinoma natural history |
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Risk calculators and risk factors for Adrenocortical carcinoma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Complications
The following are the complications of Adrenocortical carcinoma:
- Cushing's syndrome
- Conn syndrome
- Hypertension
- Virilization
- Feminization
- Local metastasis and tumor thrombus formation
- Paraneoplastic syndrome
- Distant metastasis
Prognosis
ACC, generally, carries a poor prognosis[1] and is unlike most tumours of the adrenal cortex, which are benign (adenomas) and only occasionally cause Cushing's syndrome. Five-year disease-free survival for a complete resection of a stage I-III ACC is approximately 30%.[1] The most important prognostic factors are:
- Age of the patient.
- Stage of the tumor.
Poor prognostic factors:
- Mitotic activity.
- Venous invasion.
- Weight more than 50 Kg.
- Diameter more than 6.5 cm.
- Ki-67/MIB1 labeling index.
References
- ↑ 1.0 1.1 Allolio B, Fassnacht M (2006). "Clinical review: Adrenocortical carcinoma: clinical update". J Clin Endocrinol Metab. 91 (6): 2027–37. PMID 16551738. Free Full Text.