Adrenocortical carcinoma pathophysiology

Adrenocortical carcinoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Overview

Adrenocortical carcinoma may be linked to a cancer syndrome that is passed down through families (inherited).

This tumor can produce the hormones cortisol, aldosterone, estrogen, or testosterone, as well as other hormones. In women the tumor often releases these hormones, which can lead to male characteristics.

Studies suggest that mutations of the tumor suppressor genes TP53 and TP57 might also be possible contributing factors for the development of Adrenocortical carcinoma.