Obliterative portal venopathy: Difference between revisions
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* Periportal fibrosis | * Periportal fibrosis | ||
* Occlusion of small | * [[Occlusion of small portal veins]] | ||
* Sclerosis of the portal venous system | * Sclerosis of the portal venous system | ||
Revision as of 05:09, 6 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: Hepatoportal sclerosis
Overview
Hepatoportal sclerosis (HPS) is a rare disorder characterized by sclerosis of the intrahepatic portal veins.
Pathophysiology
Pathology
Histopathologic findings are
- Periportal fibrosis
- Sclerosis of the portal venous system
- Proliferation of small vascular channels within/around portal tracts
Causes
- Exposure to toxic substances (arsenic or vinyl chloride)
- autoimmune and connective tissue diseases
- systemic or intra abdominal infections
- Clotting factor abnormalities
Differentiating from other Diseases
Differential diagnosis from liver cirrhosis is crucial and may be difficult. A large liver biopsy specimen, together with expertise and awareness of the examiner, are requested for optimal diagnosis.
Epidemiology and Demographics
The prevalence of this disease is unknown, and the distribution is worldwide, with many cases reported in Asia.
Age
The disease can occur at any age.
Gender
Both males and females are equally affected.