Chronic lymphocytic leukemia epidemiology and demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Epidemiology

Incidence

The incidence of CLL in developed countries is 4 per 100,000. It increases to more than 30 per 100,000 at age 80 yrs.

Prevalence

The prevalence of CLL ranges from a low of 10 per 100,000 patients, to a high of 50 per 100,000 patients with an average prevalence of 30 per 100,000 patients.

Age

CLL is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age. Of note, subclinical "disease" can be identified in up to 7-8% of individuals over the age of 70. That is, small clones of B cells with the characteristic CLL phenotype can be identified in many healthy elderly persons. The clinical significance of these cells is unknown.

Gender

CLL is more common in men. Two thirds of the patients are men.

Race

CLL is common in the white race compared to the black race.