Coccidioidomycosis pathophysiology

Coccidioidomycosis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathophysiology

C. immitis resides in the soil in certain parts of the southwestern United States, northern Mexico, and parts of Central and South America [2]. It is dormant during long dry spells, then develops as a mold with long filaments that break off into airborne spores when the rains come. The spores, known as arthroconidia, are swept into the air by disruption of the soil, such as during construction or farming. Infection is caused by inhalation of the particles. The disease is not transmitted from person to person. C. immitis is a dimorphic saprophytic organism that grows as a mycelium in the soil and produces a spherule form in the host organism.

Microscopic Pathology

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