Bicalutamide: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
No edit summary
Line 42: Line 42:
== Adverse reactions ==
== Adverse reactions ==
[[Adverse drug reaction|Adverse reaction]]s include reproductive system and breast disorders, breast tenderness, [[gynaecomastia]], hot flushes, gastrointestinal disorders, diarrhoea, nausea, hepatic changes (elevated levels of [[transaminase]]s, jaundice), [[asthenia]] and pruritus.
[[Adverse drug reaction|Adverse reaction]]s include reproductive system and breast disorders, breast tenderness, [[gynaecomastia]], hot flushes, gastrointestinal disorders, diarrhoea, nausea, hepatic changes (elevated levels of [[transaminase]]s, jaundice), [[asthenia]] and pruritus.
==Pill Images==
{{TempDrugImages}}
{{PillImage|fileName=CASODEX_NDC_03100705.jpg|drugName=CASODEX|NDC=03100705|drugAuthor=AstraZeneca Pharmaceuticals LP|ingredients=BICALUTAMIDE[BICALUTAMIDE]|pillImprint=CDX50|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
{{PillImage|fileName=Bicalutamide_NDC_03787017.jpg|drugName=Bicalutamide|NDC=03787017|drugAuthor=Mylan Pharmaceuticals Inc|ingredients=Bicalutamide[Bicalutamide]|pillImprint=M;C17|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=6|pillScore=1}}
{{PillImage|fileName=Bicalutamide_NDC_519910560.jpg|drugName=Bicalutamide|NDC=519910560|drugAuthor=Breckenridge Pharmaceutical, Inc.|ingredients=Bicalutamide[Bicalutamide]|pillImprint=BCM;50|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
{{PillImage|fileName=Bicalutamide_NDC_604290226.jpg|drugName=Bicalutamide|NDC=604290226|drugAuthor=Golden State Medical Supply, Inc.|ingredients=Bicalutamide[Bicalutamide]|pillImprint=BCM;50|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
{{PillImage|fileName=Bicalutamide_NDC_00930220.jpg|drugName=Bicalutamide|NDC=00930220|drugAuthor=Teva Pharmaceuticals USA Inc|ingredients=BICALUTAMIDE[BICALUTAMIDE]|pillImprint=93;220|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}
{{PillImage|fileName=Bicalutamide_NDC_167140571.jpg|drugName=Bicalutamide|NDC=167140571|drugAuthor=Northstar Rx LLC|ingredients=BICALUTAMIDE[BICALUTAMIDE]|pillImprint=B;50|dosageValue=50|dosageUnit=mg|pillColor=White|pillShape=Round|pillSize=7|pillScore=1}}


== External links ==
== External links ==

Revision as of 22:36, 16 July 2014


For patient information, click here.

Bicalutamide
Clinical data
Pregnancy
category
  • US: X (Contraindicated)
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailabilitywell absorbed
Protein binding96%
Metabolismhepatic
Elimination half-life5.8 days
Identifiers
CAS Number
PubChem CID
DrugBank
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC18H14F4N2O4S
Molar mass430.374 g/mol

Bicalutamide (marketed as Casodex®, Cosudex®, Calutide®, Kalumid®) is an oral non-steroidal anti-androgen for prostate cancer. It was first launched in 1995 as a combination treatment (with surgical or medical castration) for advanced prostate cancer and subsequently launched as monotherapy for the treatment of earlier stages of the disease.

It is marketed by AstraZeneca with the brand names Casodex and Cosudex. Bicalutamide is recommended 50 mg once daily in combination with an LHRH analogue or surgical castration.

Description

Bicalutamide is an oral non-steroidal anti-androgen with the empirical formula C18H14N2O4F4S and is an off-white powder that is practically insoluble in water.

Indications and use

For the treatment of stage D2 metastatic prostate cancer in combination with a luteinizing hormone-releasing hormone analogue or as a monotherapy. Has been used in clinical trials for ovarian cancer.

Contraindications and precautions

Bicalutamide is contra-indicated in females and children and must not be given to any patient who has shown a hypersensitivity reaction to its use.

Adverse reactions

Adverse reactions include reproductive system and breast disorders, breast tenderness, gynaecomastia, hot flushes, gastrointestinal disorders, diarrhoea, nausea, hepatic changes (elevated levels of transaminases, jaundice), asthenia and pruritus.

Pill Images

{{#ask: Page Name::Bicalutamide |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }} {{#subobject: 

 |Page Name=Bicalutamide
 |Pill Name=CASODEX_NDC_03100705.jpg
 |Drug Name=CASODEX
 |Pill Ingred=BICALUTAMIDE[BICALUTAMIDE]|+sep=;
 |Pill Imprint=CDX50
 |Pill Dosage=50 mg
 |Pill Color=White|+sep=;
 |Pill Shape=Round
 |Pill Size (mm)=7
 |Pill Scoring=1
 |Pill Image=
 |Drug Author=AstraZeneca Pharmaceuticals LP
 |NDC=03100705

}}

{{#subobject: 

 |Page Name=Bicalutamide
 |Pill Name=Bicalutamide_NDC_03787017.jpg
 |Drug Name=Bicalutamide
 |Pill Ingred=Bicalutamide[Bicalutamide]|+sep=;
 |Pill Imprint=M;C17
 |Pill Dosage=50 mg
 |Pill Color=White|+sep=;
 |Pill Shape=Round
 |Pill Size (mm)=6
 |Pill Scoring=1
 |Pill Image=
 |Drug Author=Mylan Pharmaceuticals Inc
 |NDC=03787017

}}

{{#subobject: 

 |Page Name=Bicalutamide
 |Pill Name=Bicalutamide_NDC_519910560.jpg
 |Drug Name=Bicalutamide
 |Pill Ingred=Bicalutamide[Bicalutamide]|+sep=;
 |Pill Imprint=BCM;50
 |Pill Dosage=50 mg
 |Pill Color=White|+sep=;
 |Pill Shape=Round
 |Pill Size (mm)=7
 |Pill Scoring=1
 |Pill Image=
 |Drug Author=Breckenridge Pharmaceutical, Inc.
 |NDC=519910560

}}

{{#subobject: 

 |Page Name=Bicalutamide
 |Pill Name=Bicalutamide_NDC_604290226.jpg
 |Drug Name=Bicalutamide
 |Pill Ingred=Bicalutamide[Bicalutamide]|+sep=;
 |Pill Imprint=BCM;50
 |Pill Dosage=50 mg
 |Pill Color=White|+sep=;
 |Pill Shape=Round
 |Pill Size (mm)=7
 |Pill Scoring=1
 |Pill Image=
 |Drug Author=Golden State Medical Supply, Inc.
 |NDC=604290226

}}

{{#subobject: 

 |Page Name=Bicalutamide
 |Pill Name=Bicalutamide_NDC_00930220.jpg
 |Drug Name=Bicalutamide
 |Pill Ingred=BICALUTAMIDE[BICALUTAMIDE]|+sep=;
 |Pill Imprint=93;220
 |Pill Dosage=50 mg
 |Pill Color=White|+sep=;
 |Pill Shape=Round
 |Pill Size (mm)=7
 |Pill Scoring=1
 |Pill Image=
 |Drug Author=Teva Pharmaceuticals USA Inc
 |NDC=00930220

}}

{{#subobject: 

 |Page Name=Bicalutamide
 |Pill Name=Bicalutamide_NDC_167140571.jpg
 |Drug Name=Bicalutamide
 |Pill Ingred=BICALUTAMIDE[BICALUTAMIDE]|+sep=;
 |Pill Imprint=B;50
 |Pill Dosage=50 mg
 |Pill Color=White|+sep=;
 |Pill Shape=Round
 |Pill Size (mm)=7
 |Pill Scoring=1
 |Pill Image=
 |Drug Author=Northstar Rx LLC
 |NDC=167140571

}}


External links

Template:Sex hormones

nl:Bicalutamide

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Bicalutamide&oldid=994710"