CYP3A7: Difference between revisions
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'''CYP3A7''' is an enzyme belonging to the [[cytochrome P450]] family. It is 503 [[amino acid]]s in size and shares 87% of its sequence with [[CYP3A4]]. It carries out a similar role in fetuses that [[CYP3A4]] serves in adults.<ref name="pmid2722762">{{cite journal | vauthors = Komori M, Nishio K, Ohi H, Kitada M, Kamataki T | title = Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450 | journal = J. Biochem. | volume = 105 | issue = 2 | pages = 161–3 |date=February 1989 | pmid = 2722762 | doi = }}</ref> The [[Locus (genetics)|gene location]] is 7q22.1.<ref>{{cite web | url=http://www.omim.org/entry/605340 | title=Cytochrome P450, Subfamily IIIA, Polypeptide 7 | publisher=OMIM | accessdate=March 14, 2013}}</ref> | |||
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The CYP3A group of enzymes are the most abundantly [[Gene expression|expressed]] members of the cytochrome P450 family in liver. They are responsible for the [[metabolism]] of more than 50% of all clinical pharmaceuticals.<ref name="pmid10898111">{{cite journal | vauthors = Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M | title = Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans | journal = Pharmacogenetics | volume = 10 | issue = 5 | pages = 415–24 |date=July 2000 | pmid = 10898111 | doi = 10.1097/00008571-200007000-00005}}</ref> | |||
==Notable alleles== | |||
The CYP3A7*1C [[allele]] is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some [[chemotherapy]] agents.<ref>[http://www.oncotherapynetwork.com/lung-cancer-targets/cyp3a71c-allele-associated-poor-outcomes-cll-breast-and-lung-cancer CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer]</ref> | |||
==References== | |||
{{reflist}} | |||
==External links== | ==External links== | ||
* {{MeshName|CYP3A7+protein,+human}} | * {{MeshName|CYP3A7+protein,+human|3=CYP3A7 protein, human}} | ||
* {{UCSC gene info|CYP3A7}} | |||
{{Cytochrome P450}} | {{Cytochrome P450}} | ||
{{Dioxygenases}} | |||
{{Enzymes}} | |||
{{Portal bar|Molecular and Cellular Biology|border=no}} | |||
[[Category:Cytochrome P450]] | [[Category:Cytochrome P450]] | ||
[[Category:EC 1.14.14]] | |||
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Latest revision as of 20:38, 9 May 2017
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CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[1] The gene location is 7q22.1.[2]
The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[3]
Notable alleles
The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[4]
References
- ↑ Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. PMID 2722762.
- ↑ "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
- ↑ Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID 10898111.
- ↑ CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer
External links
- CYP3A7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CYP3A7 genome location and CYP3A7 gene details page in the UCSC Genome Browser.
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