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'''CYP4X1''' ('''cy'''tochrome '''P'''450, family '''4''', subfamily '''X''', polypeptide '''1''') is a [[protein]] which in humans is encoded by the ''CYP4X1'' [[gene]].<ref name="pmid12176035">{{cite journal | title = Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain | journal = Biochem. Biophys. Res. Commun. | volume = 296 | issue = 3 | pages = 677–84 |date=August 2002 | pmid = 12176035 | doi = 10.1016/S0006-291X(02)00918-X| url = http://linkinghub.elsevier.com/retrieve/pii/S0006291X0200918X| author1 = Bylund J | author2 = Zhang C | author3 = Harder DR |name-list-format=vanc }}</ref> | |||
This gene encodes a member of the [[cytochrome P450]] superfamily of [[enzyme]]s. The cytochrome P450 proteins are [[monooxygenase]]s which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain.<ref name="entrez_2532">{{cite web | title = Entrez Gene: CYP4X1 | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=260293 | accessdate = }}</ref> | |||
==References== | ==References== | ||
{{Reflist}} | {{Reflist}} | ||
==Further reading== | |||
{{refbegin | 2}} | |||
*{{cite journal |vauthors=Clark HF, Gurney AL, Abaya E |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 |pmc=403697 |display-authors=etal}} | |||
*{{cite journal |vauthors=Savas U, Hsu MH, Griffin KJ |title=Conditional regulation of the human CYP4X1 and CYP4Z1 genes |journal=Arch. Biochem. Biophys. |volume=436 |issue= 2 |pages= 377–85 |year= 2005 |pmid= 15797250 |doi= 10.1016/j.abb.2005.02.022 |display-authors=etal}} | |||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |display-authors=etal}} | |||
*{{cite journal |vauthors=Nelson DR, Zeldin DC, Hoffman SM |title=Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants |journal=Pharmacogenetics |volume=14 |issue= 1 |pages= 1–18 |year= 2004 |pmid= 15128046 |doi=10.1097/00008571-200401000-00001 |display-authors=etal}} | |||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 |display-authors=etal}} | |||
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}} | |||
{{refend}} | |||
{{NLM content}} | {{NLM content}} | ||
{{Cytochrome P450}} | |||
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Revision as of 10:16, 30 August 2017
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CYP4X1 (cytochrome P450, family 4, subfamily X, polypeptide 1) is a protein which in humans is encoded by the CYP4X1 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain.[2]
References
- ↑ Bylund J, Zhang C, Harder DR (August 2002). "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain". Biochem. Biophys. Res. Commun. 296 (3): 677–84. doi:10.1016/S0006-291X(02)00918-X. PMID 12176035.
- ↑ "Entrez Gene: CYP4X1".
Further reading
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Savas U, Hsu MH, Griffin KJ, et al. (2005). "Conditional regulation of the human CYP4X1 and CYP4Z1 genes". Arch. Biochem. Biophys. 436 (2): 377–85. doi:10.1016/j.abb.2005.02.022. PMID 15797250.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Nelson DR, Zeldin DC, Hoffman SM, et al. (2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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