Clofoctol: Difference between revisions

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Clofoctol
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Rectal (suppository)
ATC code	J01XX03 (WHO) ;
Pharmacokinetic data
Bioavailability	98%
Metabolism	Hepatic glucuronidation
Excretion	Biliary
Identifiers
	IUPAC name 2-[(2,4-dichlorophenyl)methyl]-; 4-(2,4,4-trimethylpentan-2-yl)phenol;
CAS Number	37693-01-9 ;
PubChem CID	2799;
ChemSpider	2697 ;
UNII	704083NI0R;
KEGG	D07244 ;
ChEMBL	ChEMBL1476605;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C21H26Cl2O
Molar mass	365.336 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc1cc(Cl)ccc1Cc2cc(ccc2O)C(C)(C)CC(C)(C)C;
	InChI InChI=1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3 ; Key:HQVZOORKDNCGCK-UHFFFAOYSA-N ;
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VisualWikitext

Latest revision as of 15:36, 14 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.^[1] It is marketed in France under the trade name Octoplus and in Italy as Gramplus.

It is only functional against Gram-positive bacteria.^[2]

It penetrates into human lung tissue.^[3]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 "Gramplus" (in Italian). Studio Medico Torrino. July 25, 2007. Retrieved 2007-08-10.
↑ Combe J, Simonnet F, Yablonsky F, Simonnet G (1980). "[Clofoctol binding by the bacteria (author's transl)]". J Pharmacol (in French). 11 (4): 411–25. PMID 6782374.
↑ Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M (1988). "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Exp Clin Res. 14 (1): 39–43. PMID 3391105.

Template:Antibiotic-stub Template:Other antibacterials

[Gramplus-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 "Gramplus" (in Italian). Studio Medico Torrino. July 25, 2007. Retrieved 2007-08-10.

[pmid6782374-2] Combe J, Simonnet F, Yablonsky F, Simonnet G (1980). "[Clofoctol binding by the bacteria (author's transl)]". J Pharmacol (in French). 11 (4): 411–25. PMID 6782374.

[pmid3391105-3] Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M (1988). "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Exp Clin Res. 14 (1): 39–43. PMID 3391105.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-{{drugbox
+{{Drugbox
-| IUPAC_name        = 2-[(2,4-dichlorophenyl)methyl]-<br>4-(2,4,4-trimethylpentan-2-yl)phenol
+| Watchedfields = changed
-| image             = Clofoctol.svg
+| verifiedrevid = 443553734
-| CAS_number        = 37693-01-9
+| IUPAC_name = 2-[(2,4-dichlorophenyl)methyl]-<br>4-(2,4,4-trimethylpentan-2-yl)phenol
-| ATC_prefix        = J01
+| image = Clofoctol Wiki Str.png
-| ATC_suffix        = XX03
-| PubChem           = 2799
+| alt = Structural formula of clofoctol
-| DrugBank          =
+| width = 250
-| C=21|H=26|Cl=2|O=1
-| molecular_weight  = 365.336 g/mol
+<!--Clinical data-->
-| bioavailability   = 98%<ref name=Gramplus/>
+| tradename =
-| protein_bound     =
+| Drugs.com = {{drugs.com|international|clofoctol}}
-| metabolism        = [[Hepatic]] [[glucuronidation]]<ref name=Gramplus/>
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| elimination_half-life =
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| excretion         = Biliary<ref name=Gramplus/>
+| pregnancy_category =
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| pregnancy_category=
+| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
+| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_status =
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| routes_of_administration = Rectal ([[suppository]])<ref name=Gramplus/>
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| legal_status      =
+<!--Pharmacokinetic data-->
-| routes_of_administration = Rectal ([[suppository]])<ref name=Gramplus/><ref name=BIAM/>
+| bioavailability = 98%<ref name=Gramplus/>
+| protein_bound =
+| metabolism = [[Hepatic]] [[glucuronidation]]<ref name=Gramplus/>
+| elimination_half-life =
+| excretion = Biliary<ref name=Gramplus/>
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 37693-01-9
+| ATC_prefix = J01
+| ATC_suffix = XX03
+| PubChem = 2799
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| ChEMBL = 1476605
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 2697
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = 704083NI0R
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D07244
+<!--Chemical data-->
+| C=21 | H=26 | Cl=2 | O=1
+| molecular_weight = 365.336 g/mol
+| smiles = Clc1cc(Cl)ccc1Cc2cc(ccc2O)C(C)(C)CC(C)(C)C
+| InChI = 1/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3
+| InChIKey = HQVZOORKDNCGCK-UHFFFAOYAB
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = HQVZOORKDNCGCK-UHFFFAOYSA-N
 }}
+__NOTOC__
 {{SI}}
+{{CMG}}
+== Overview ==
+'''Clofoctol''' is a [[bacteriostatic]] [[antibiotic]]. It is used in the treatment of [[respiratory tract]] and ear, nose and throat infections caused by [[Gram-positive]] [[bacteria]].<ref name=Gramplus>{{cite web | url = http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm | title = Gramplus | date = July 25, 2007 | accessdate = 2007-08-10 | publisher = Studio Medico Torrino | language = Italian}}</ref>
+It is marketed in [[France]] under the trade name '''Octoplus''' and in [[Italy]] as '''Gramplus'''.
-'''Clofoctol''' is a [[bacteriostatic]] [[antibiotic]]. It is used in the treatment of [[respiratory tract]] and ear, nose and throat infections caused by [[Gram-positive]] [[bacteria]].<ref name=Gramplus>{{cite web | url = http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm | title = Gramplus | date = [[July 25]] [[2007]] | accessdate = 2007-08-10 | publisher = Studio Medico Torrino | language = Italian}}</ref><ref name=BIAM>{{cite web | url = http://www.biam2.org/www/Sub3508.html | title = Clofoctol | date = [[July 16]] [[1999]] | accessdate = 2007-08-10 | publisher = BIAM | language = French}}</ref>
+It is only functional against [[Gram-positive bacteria]].<ref name="pmid6782374">{{cite journal |author=Combe J, Simonnet F, Yablonsky F, Simonnet G |title=[Clofoctol binding by the bacteria (author's transl)] |language=French |journal=J Pharmacol |volume=11 |issue=4 |pages=411–25 |year=1980 |pmid=6782374 |doi=}}</ref>
-It is marketed in [[France]] under the trade name '''Octoplus''' and in [[Italy]] as '''Gramplus'''.
+It penetrates into human lung tissue.<ref name="pmid3391105">{{cite journal |author=Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M |title=A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay |journal=Drugs Exp Clin Res |volume=14 |issue=1 |pages=39–43 |year=1988 |pmid=3391105 |doi= |url=}}</ref>
 ==References==
-{{Reflist}}
+{{Reflist|2}}
+{{Antibiotic-stub}}
 {{Other antibacterials}}
+[[Category:drug]]
 [[Category:Antibiotics]]
+[[Category:Phenols]]
+[[Category:Organochlorides]]
-{{WikiDoc Help Menu}}
-{{WS}}

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Rectal (suppository)^[1]
ATC code	J01XX03 (WHO)
Pharmacokinetic data
Bioavailability	98%^[1]
Metabolism	Hepatic glucuronidation^[1]
Excretion	Biliary^[1]
Identifiers
IUPAC name 2-[(2,4-dichlorophenyl)methyl]- 4-(2,4,4-trimethylpentan-2-yl)phenol
CAS Number	37693-01-9^Y
PubChem CID	2799
ChemSpider	2697^Y
UNII	704083NI0R
KEGG	D07244^Y
ChEMBL	ChEMBL1476605
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₂₁H₂₆Cl₂O
Molar mass	365.336 g/mol
3D model (JSmol)	Interactive image
SMILES Clc1cc(Cl)ccc1Cc2cc(ccc2O)C(C)(C)CC(C)(C)C
InChI InChI=1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3^Y Key:HQVZOORKDNCGCK-UHFFFAOYSA-N^Y
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Clofoctol: Difference between revisions

Latest revision as of 15:36, 14 April 2015

Overview

References

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