Diazoxide detailed information: Difference between revisions

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#REDIRECT [[Diazoxide#Pharmacology]]
{{drugbox
| IUPAC_name = 7-chloro-3-methyl-4''H''-1,2,4-benzothiadiazine 1,1-dioxide
| image = Diazoxide_svg.png
| CAS_number = 364-98-7
| ATC_prefix = C02
| ATC_suffix = DA01
| ATC_supplemental = {{ATC|V03|AH01}}
| PubChem = 3019
| DrugBank = APRD00914
| C = 8 | H = 7 | Cl = 1 | N = 2 | O = 2 | S = 1
| molecular_weight = 230.672 g/mol
| bioavailability =
| protein_bound = 90%
| metabolism = [[Liver|Hepatic]] [[oxidation]] and [[sulfate]] conjugation
| elimination_half-life = 21-45 hours
| excretion = [[Kidney|Renal]]
| pregnancy_AU = C
| pregnancy_US = C
| legal_UK = POM
| legal_US = Rx-only
| routes_of_administration = Oral, [[Intravenous therapy|intravenous]]
}}
{{CMG}}
 
 
 
'''Diazoxide''' is a [[potassium channel]] activator, which causes local relaxation in [[smooth muscle]] by increasing membrane [[Semipermeable membrane|permeability]] to potassium [[ion]]s. This switches off voltage-gated [[calcium]] ion channels which inhibits the generation of an [[action potential]].
 
It is used as a [[vasodilator]] in the treatment of acute [[hypertension]], and also to decrease the secretion of [[insulin]] in disease states such as [[insulinoma]] (a tumor producing insulin).
 
 
{{Antihypertensives and diuretics}}
 
[[Category:Sulfonamides]]
[[Category:Vasodilators]]
[[Category:Drugs]]
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[[de:Diazoxid]]
[[fr:Diazoxide]]
[[hr:Diazoksid]]

Latest revision as of 02:06, 22 July 2014