Dihydropyrimidine dehydrogenase: Difference between revisions

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{{Infobox enzyme
| name = Dihydropyrimidine dehydrogenase (NADP(+))
| AltNames =Dihydrothymine dehydrogenase
| image =
| image_size =
| caption =
| EC_number = 1.3.1.2
| CAS_number = 9029-01-0
| GO_code = 0017113
}}
'''Dihydropyrimidine dehydrogenase''' ('''DPD''') is an [[enzyme]] that is involved in [[pyrimidine]] degradation. It is the initial and rate-limiting step in pyrimidine catabolism.{{fact|date=April 2017}} It catalyzes the reduction of [[uracil]] and [[thymine]].<ref name="Chung" /> It is also involved in the degradation of the chemotherapeutic drugs [[5-fluorouracil]] and [[tegafur]].<ref name="Caudle" />


==Overview==
== See also ==
'''Dihydropyrimidine dehydrogenase''' ('''DPD''') is an [[enzyme]] that is involved in [[pyrimidine]] degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of [[uracil]] and [[thymine]]. It is also involved in the degradation of the chemotherapeutic drug [[5-fluorouracil]].
* [[Dihydropyrimidine dehydrogenase deficiency]], a genetic disorder


==See also==
== References ==
* [[Dihydropyrimidine dehydrogenase deficiency]]
{{reflist|refs=


==External links==
<ref name="Chung">{{cite journal | vauthors = Chung T, Na J, Kim YI, Chang DY, Kim YI, Kim H, Moon HE, Kang KW, Lee DS, Chung JK, Kim SS, Suh-Kim H, Paek SH, Youn H | title = Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas | journal = Theranostics | volume = 6 | issue = 10 | pages = 1477–90 | year = 2016 | pmid = 27446484 | pmc = 4955049 | doi = 10.7150/thno.14158 }}</ref>
* [http://www.mdl-labs.com  dpd genotype testing (www.mdl-labs.com)]


<ref name="Caudle">{{cite journal | vauthors = Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M | title = Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing | journal = Clinical Pharmacology and Therapeutics | volume = 94 | issue = 6 | pages = 640–5 | date = December 2013 | pmid = 23988873 | pmc = 3831181 | doi = 10.1038/clpt.2013.172 }}</ref>
}}


{{Nucleotide metabolism}}
{{Nucleotide metabolism}}
{{WH}}
 
{{WS}}
[[Category:EC 1.3.1]]
 
{{enzyme-stub}}

Revision as of 11:30, 15 April 2017

dihydropyrimidine dehydrogenase
Identifiers
SymbolDPYD
Entrez1806
HUGO3012
OMIM274270
RefSeqNM_000110
Other data
EC number1.3.1.2
LocusChr. 1 p22
Dihydropyrimidine dehydrogenase (NADP(+))
Identifiers
EC number1.3.1.2
CAS number9029-01-0
Alt. namesDihydrothymine dehydrogenase
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism.[citation needed] It catalyzes the reduction of uracil and thymine.[1] It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur.[2]

See also

References

  1. ↑ Chung T, Na J, Kim YI, Chang DY, Kim YI, Kim H, Moon HE, Kang KW, Lee DS, Chung JK, Kim SS, Suh-Kim H, Paek SH, Youn H (2016). "Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas". Theranostics. 6 (10): 1477–90. doi:10.7150/thno.14158. PMC 4955049. PMID 27446484.
  2. ↑ Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M (December 2013). "Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing". Clinical Pharmacology and Therapeutics. 94 (6): 640–5. doi:10.1038/clpt.2013.172. PMC 3831181. PMID 23988873.
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