Iron overload disorder

Iron overload disorder
ICD-10	R79.0
ICD-9	790.6

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

In medicine, iron overload disorders are diseases caused by the accumulation of iron in the body. Organs commonly affected are the liver, heart and endocrine glands.

Causes

The causes can be distinguished between primary (generally genetic) and secondary (due to other conditions).

Primary iron overload

Description	OMIM	Mutation
Haemochromatosis type 1: "classical"-haemochromatosis	235200	HFE
Haemochromatosis type 2A: juvenile haemochromatosis	602390	hemojuvelin ("HJV", also known as HFE2)
Haemochromatosis type 2B: juvenile haemochromatosis	606464	hepcidin antimicrobial peptide (HAMP) or HFE2B
Haemochromatosis type 3	604720	transferrin receptor-2 (TFR2 or HFE3)
Haemochromatosis type 4	604653	ferroportin (SLC11A3)
Neonatal haemochromatosis	231100	(unknown)
Aceruloplasminaemia (rare disease)	604290	ceruloplasmin
Congenital atransferrinaemia (rare disease)	209300	transferrin

Secondary iron overload

• Dietary iron overload
• Increased intake of drugs such as ferrous gluconate.
• Transfusional iron overload
• Long term haemodialysis
• Chronic liver disease
  • Hepatitis C
  • Alcoholic cirrhosis, especially when advanced
  • Non-alcoholic steatohepatitis
• Porphyria cutanea tarda
• Post-portacaval shunting
• Dysmetabolic iron overload syndrome

Miscellaneous

The part-genetic, part-environmental syndrome known as African iron overload in sub-Sahara Africa (Online Mendelian Inheritance in Man (OMIM) 601195)

See also

• Iron deficiency
• Siderosis
• Human iron metabolism

External links

• Texas Medical Center
• Merck
• Iron Overload.org

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