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==Overview==
==Overview==
This is a list of specific [[Wiktionary:pharmacological agent|pharmacologic agents]] that are known to be of use in the treatment of [[cancer]], otherwise known as '''[[Wiktionary:chemotherapeutic agent|chemotherapeutic agents]]'''.  This list is organized by "type" of agent, though the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection.
This is a '''list of chemotherapeutic agents''' (also known as '''cytotoxic agents''') that are known to be of use in [[chemotherapy]] for [[cancer]].  This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing.


A full alphabetical listing is included after the categorical listing.
The agents in this list are often combined into [[chemotherapy regimens]] for polychemotherapy (combination chemotherapy). For example, the [[CHOP]] regimen consists of [[cyclophosphamide]], [[hydroxydaunorubicin]] (doxorubicin), [[vincristine]] (Oncovin), and prednisone.  


{{listdev}}
Besides chemotherapy, medical oncology ([[pharmacotherapy]] for cancer) includes several noncytotoxic classes of therapy, such as [[hormonal therapy (oncology)|hormonal therapy]] and [[targeted therapy]] (biologic therapy). Those agents are described in the relevant articles.


== Alkylating agents ==
== Alkylating agents ==
{{Main|Alkylating agent}}
'''Bifunctional Alkylators'''
* [[Cyclophosphamide]]
* [[Cyclophosphamide]]
* [[Mechlorethamine]]
* [[Mechlorethamine]]
* [[Chlorambucil]]
* [[Chlorambucil]]
* [[Melphalan]]
* [[Melphalan]]
'''Monofunctional Alkylators'''
* [[Nitrosoureas]]
* [[Temozolomide]]


== Anthracyclines ==
== Anthracyclines ==
''article on [[anthracycline]]s''
{{Main|anthracycline}}
* [[Daunorubicin]]
* [[Daunorubicin]]
* [[Doxorubicin]]
* [[Doxorubicin]]
Line 24: Line 31:
* [[Valrubicin]]
* [[Valrubicin]]


== Cytoskeletal disruptors ==
== Cytoskeletal disruptors (Taxanes) ==
{{Main|Taxane}}
* [[Paclitaxel]]
* [[Paclitaxel]]
* [[Docetaxel]]
* [[Docetaxel]]


== Epothilones ==
== Epothilones ==
''article on [[epothilone]]s''
{{Main|epothilone}}


== Inhibitors of topoisomerase II ==
== Histone Deacetylase Inhibitors ==
* [[Vorinostat]]
* [[Romidepsin]]
 
== Inhibitors of Topoisomerase I ==
{{Main|Topoisomerase inhibitor}}
* [[Irinotecan]]
* [[Topotecan]]
 
== Inhibitors of Topoisomerase II ==
{{Main|Topoisomerase II inhibitor}}
* [[Etoposide]]
* [[Etoposide]]
* [[Teniposide]]
* [[Teniposide]]
* [[Tafluposide]]
* [[Tafluposide]]
== Kinase inhibitors ==
{{Main|Kinase inhibitor}}
* [[Bortezomib]]
* [[Erlotinib]]
* [[Gefitinib]]
* [[Imatinib]]
* [[Vemurafenib]]
* [[Vismodegib]]


== Nucleotide analogs and precursor analogs ==
== Nucleotide analogs and precursor analogs ==
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* [[Fluorouracil]]
* [[Fluorouracil]]
* [[Gemcitabine]]
* [[Gemcitabine]]
* [[Hydroxyurea]]
* [[Mercaptopurine]]
* [[Mercaptopurine]]
* [[Methotrexate]]
* [[Methotrexate]]
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== Peptide antibiotics ==
== Peptide antibiotics ==
* [[Bleomycin]]
* [[Bleomycin]]
* [[Actinomycin]]


== Platinum-based agents ==
== Platinum-based agents ==
{{Main|Platinum-based antineoplastic}}
* [[Carboplatin]]
* [[Carboplatin]]
* [[Cisplatin]]
* [[Cisplatin]]
Line 57: Line 87:


== Retinoids ==
== Retinoids ==
* [[All-trans retinoic acid]]
* [[Tretinoin]]
* [[Alitretinoin]]
* [[Bexarotene]]


== Vinca alkaloids and derivatives ==
== Vinca alkaloids and derivatives ==
{{Main|Vinca alkaloid}}
* [[Vinblastine]]
* [[Vinblastine]]
* [[Vincristine]]
* [[Vincristine]]
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* [[Vinorelbine]]
* [[Vinorelbine]]


== Full alphabetical listing ==
==Chemotherapeutic Agents in Alphabetical Order==
* [[All-trans retinoic acid]]
* [[Abiraterone|Abiraterone acetate (Zytiga)]]
* [[Azacitidine]]
* [[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
* [[Azathioprine]]
* [[Afatinib|Afatinib (Gliotrif)]]
* [[Bleomycin]]
* [[Aldesleukin|Aldesleukin (Proleukin)]]
* [[Carboplatin]]
* [[Altretamine|Altretamine (Hexalen)]]
* [[Capecitabine]]
* [[Amifostine|Amifostine (Ethyol)]]
* [[Cisplatin]]
* [[Anastrozole|Anastrozole (Arimidex)]]
* [[Chlorambucil]]
* [[Arsenic trioxide|Arsenic trioxide (Trisenox)]]
* [[Cyclophosphamide]]
* [[Asparaginase Erwinia chrysanthemi|Asparaginase Erwinia chrysanthemi (Erwinaze)]]
* [[Cytarabine]]
* [[Axitinib|Axitinib (Inlyta)]]
* [[Daunorubicin]]
* [[Azacytidine|Azacytidine (Vidaza)]]
* [[Docetaxel]]
* [[Belinostat|Belinostat (Beleodaq)]]
* [[Doxifluridine]]
* [[Bendamustine|Bendamustine (Treanda)]]
* [[Doxorubicin]]
* [[Bevacizumab|Bevacizumab (Avastin)]]
* [[Epirubicin]]
* [[Bexarotene|Bexarotene (Targretin)]]
* [[Epothilone]]
* [[Bicalutamide|Bicalutamide (Casodex)]]
* [[Etoposide]]
* [[Bleomycin|Bleomycin (Blenoxane)]]
* [[Fluorouracil]]
* [[Blinatumomab|Blinatumomab (Blincyto)]]
* [[Gemcitabine]]
* [[Bosutinib|Bosutinib (Bosulif)]]
* [[Hydroxyurea]] ''requires categorization''
* [[Brentuximab vedotin|Brentuximab vedotin (Adcetris)]]
* [[Idarubicin]]
* [[Buserelin|Buserelin (Suprefact)]]
* [[Imatinib]]
* [[Busulfan|Busulfan (Myleran-oral)]]
* [[Mechlorethamine]]
* [[Cabazitaxel|Cabazitaxel (Jevtana)]]
* [[Mercaptopurine]]
* [[Cabozantinib|Cabozantinib (Cometriq)]]
* [[Methotrexate]]
* [[Capecitabine|Capecitabine (Xeloda)]]
* [[Mitoxantrone]]
* [[Carboplatin|Carboplatin (Paraplatin)]]
* [[Oxaliplatin]]
* [[Carfilzomib|Carfilzomib (Kyprolis)]]
* [[Paclitaxel]]
* [[Carmustine|Carmustine (BiCNU)]]
* [[Pemetrexed]]
* [[Ceritinib|Ceritinib (Zykadia)]]
* [[Teniposide]]
* [[Cetuximab|Cetuximab (Erbitux)]]
* [[Tioguanine]]
* [[Chlorambucil|Chlorambucil (Leukeran)]]
* [[Valrubicin]]
* [[Cisplatin|Cisplatin (Platinol)]]
* [[Vinblastine]]
* [[Crizotinib|Crizotinib (Xalkori)]]
* [[Vincristine]]
* [[Dabrafenib|Dabrafenib (Tafinlar)]]
* [[Vindesine]]
* [[Dasatinib|Dasatinib (Sprycel)]]
* [[Vinorelbine]]
* [[Daunorubicin|Daunorubicin (Daunoxome)]]
 
* [[Decitabine|Decitabine (Dacogen)]]
 
* [[Degarelix|Degarelix (Firmagon)]]
 
* [[Denileukin diftitox|Denileukin diftitox (Ontak)]]
[[Category:Chemotherapeutic agents| ]]
* [[Denosumab|Denosumab (Xgeva)]]
* [[Dexamethasone|Dexamethasone (Decadron)]]
* [[Dexrazoxane|Dexrazoxane (Zinecard)]]
* [[Docetaxel|Docetaxel (Taxotere)]]
* [[Doxorubicin|Doxorubicin (Adriamycin, Rubex)]]
* [[Enzalutamide|Enzalutamide (Xtandi)]]
* [[Epirubicin|Epirubicin (Ellence)]]
* [[Eribulin mesylate|Eribulin (Halaven)]]
* [[Erlotinib|Erlotinib (Tarceva)]]
* [[Erythropoietin|Erythropoietin (Epogen, Procrit)]]
* [[Estramustine|Estramustine (Emcyt)]]
* [[Etoposide|Etoposide (Vespid)]]
* [[Everolimus|Everolimus (Afinitor)]]
* [[Exemestane|Exemestane (Aromasin)]]
* [[Filgrastim|Filgrastim (Neupogen)]]
* [[Floxuridine|Floxuridine (FUDR)]]
* [[Fludarabine|Fludarabine (Fludara)]]
* [[Fluorouracil|Fluorouracil (Adrucil, Efudex)]]
* [[Fluoxymesterone|Fluoxymesterone (Halotestin)]]
* [[Flutamide|Flutamide (Eulexin)]]
* [[Folinic acid|Folinic acid (Leucovorin Calcium)]]
* [[Fulvestrant|Fulvestrant (Faslodex)]]
* [[Gallium nitrate|Gallium Nitrate (Ganite)]]
* [[Gemcitabine|Gemcitabine (Gemzar)]]
* [[Gemtuzumab ozogamicin|Gemtuzumab ozogamicin (Mylotarg)]]
* [[Glucarpidase|Glucarpidase (Voraxaze)]]
* [[Goserelin acetate|Goserelin Acetate (Zoladex)]]
* [[Hydroxyurea|Hydroxyurea (Hydrea)]]
* [[Ibritumomab tiuxetan|Ibritumomab tiuxetan (Zevalin)]]
* [[Ibrutinib|Ibrutinib (Imbruvica)]]
* [[Idarubicin|Idarubicin (Idamycin)]]
* [[Idelalisib|Idelalisib (Zydelig)]]
* [[Ifosfamide|Ifosfamide (Ifex)]]
* [[interferon alfa-2b|interferon alfa-2b (Intron A)]]
* [[Ipilimumab|Ipilimumab (Yervoy)]]
* [[Irinotecan|Irinotecan (Camptosar)]]
* [[Isotretinoin|Isotretinoin (Accutane)]]
* [[Ixabepilone|Ixabepilone (Ixempra)]]
* [[L-Asparaginase|L-Asparaginase (Elspar)]]
* [[Lapatinib|Lapatinib (Tykerb)]]
* [[Lenalidomide|Lenalidomide (Revlimid)]]
* [[Letrozole|Letrozole (Femara)]]
* [[Leuprolide|Leuprolide (Lupron)]]
* [[Levoleucovorin|Levoleucovorin (Fusilev)]]
* [[Lomustine|Lomustine (CeeNU)]]
* [[Mechlorethamine|Mechlorethamine (Mustargen)]]
* [[Medroxyprogesterone acetate|Medroxyprogesterone acetate (Provera)]]
* [[Megestrol|Megestrol (Megace)]]
* [[Melphalan|Melphalan (Alkeran)]]
* [[Mercaptopurine|Mercaptopurine (Purinethol)]]
* [[Mesna|Mesna (Mesnex)]]
* [[Methotrexate|Methotrexate (Mexate, Folex)]]
* [[Mitomycin C|Mitomycin C (Mutamycin)]]
* [[Mitotane|Mitotane (Lysodren)]]
* [[Mitoxantrone|Mitoxantrone (Novantrone)]]
* [[Nelarabine|Nelarabine (Arranon)]]
* [[Netupitant and palonosetron|Netupitant and palonosetron (Akynzeo)]]
* [[Nilotinib|Nilotinib (Tasigna)]]
* [[Nilutamide|Nilutamide (Nilandron)]]
* [[Nivolumab|Nivolumab (Opdivo)]]
* [[Obinutuzumab|Obinutuzumab (Gazyva)]]
* [[Octreotide|Octreotide (Octreotide)]]
* [[Ofatumumab|Ofatumumab (Arzerra)]]
* [[Olaparib|Olaparib (Lynparza)]]
* [[Omacetaxine|Omacetaxine (Synribo)]]
* [[Oprelvekin|Oprelvekin (Neumega)]]
* [[Oxaliplatin|Oxaliplatin (Eloxatin)]]
* [[Paclitaxel|Paclitaxel (Taxol, Onxol)]]
* [[Pamidronate|Pamidronate (Aredia)]]
* [[Panitumumab|Panitumumab (Vectibix)]]
* [[Pazopanib|Pazopanib (Votrient)]]
* [[Pegaspargase|PEG-Asparaginase (Oncaspar)]]
* [[Pegfilgrastim|Pegfilgrastim (Neulasta)]]
* [[Pegylated interferon alfa-2b|Peginterferon alfa-2b (Sylatron)]]
* [[Pembrolizumab|Pembrolizumab (Keytruda)]]
* [[Pemetrexed|Pemetrexed (Alimta)]]
* [[Pentostatin|Pentostatin (Nipent)]]
* [[Pertuzumab|Pertuzumab (Perjeta)]]
* [[Plerixafor|Plerixafor (Mozobil)]]
* [[Pomalidomide|Pomalidomide (Pomalyst)]]
* [[Ponatinib|Ponatinib (Iclusig)]]
* [[Pralatrexate|Pralatrexate (Folotyn)]]
* [[Prednisone|Prednisone (Deltasone)]]
* [[Procarbazine|Procarbazine (Matulane)]]
* [[Radium-223 chloride|Radium-223 chloride (Xofigo)]]
* [[Ramucirumab|Ramucirumab (Cyramza)]]
* [[Rasburicase|Rasburicase (Elitek)]]
* [[Regorafenib|Regorafenib (Stivarga)]]
* [[Rituximab|Rituximab (Rituxan)]]
* [[Romidepsin|Romidepsin (Istodax)]]
* [[Ruxolitinib|Ruxolitinib (Jakafi)]]
* [[Sargramostim|Sargramostim (Leukine, Leukomax)]]
* [[Siltuximab|Siltuximab (Sylvant)]]
* [[Sipuleucel-T|Sipuleucel-T (Provenge)]]
* [[Sorafenib|Sorafenib (Nexavar)]]
* [[Streptozocin|Streptozocin (Zanosar)]]
* [[Sunitinib|Sunitinib (Sutent)]]
* [[Tamoxifen|Tamoxifen (Nolvadex)]]
* [[Tbo-filgrastim|Tbo-filgrastim (Granix)]]
* [[Temozolomide|Temozolomide (Temodar)]]
* [[Temsirolimus|Temsirolimus (Torisel)]]
* [[Teniposide|Teniposide (Vumon)]]
* [[Thalidomide|Thalidomide (Thalomid)]]
* [[Thioguanine|Thioguanine (Tabloid)]]
* [[Thiotepa|Thiotepa (TESPA)]]
* [[Tocilizumab|Tocilizumab (Actemra)]]
* [[Topotecan|Topotecan (Hycamtin)]]
* [[Toremifene|Toremifene (Fareston)]]
* [[Trametinib|Trametinib (Mekinist)]]
* [[Trastuzumab|Trastuzumab (Herceptin)]]
* [[Tretinoin|Tretinoin (Vesanoid)]]
* [[Vandetanib|Vandetanib (Caprelsa)]]
* [[Vemurafenib|Vemurafenib (Zelboraf)]]
* [[Vinblastine|Vinblastine (Velban, Velsar)]]
* [[Vincristine|Vincristine (Oncovin, Vincasar)]]
* [[Vincristine liposomal|Vincristine liposomal (Marqibo)]]
* [[Vinorelbine|Vinorelbine (Navelbine)]]
* [[Vismodegib|Vismodegib (Erivedge)]]
* [[Ziv-aflibercept|Ziv-aflibercept (Zaltrap)]]
* [[Zoledronic acid|Zoledronic Acid (Zometa)]]


[[de:Zytostatikum]]
[[Category:Chemotherapeutic agents]]
[[fr:Agent chimiothérapeutique]]
[[nl:Cytostaticum]]
[[pl:Leki cytostatyczne]]
{{WH}}
{{WS}}

Revision as of 05:36, 2 February 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Overview

This is a list of chemotherapeutic agents (also known as cytotoxic agents) that are known to be of use in chemotherapy for cancer. This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing.

The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy). For example, the CHOP regimen consists of cyclophosphamide, hydroxydaunorubicin (doxorubicin), vincristine (Oncovin), and prednisone.

Besides chemotherapy, medical oncology (pharmacotherapy for cancer) includes several noncytotoxic classes of therapy, such as hormonal therapy and targeted therapy (biologic therapy). Those agents are described in the relevant articles.

Alkylating agents

Bifunctional Alkylators

Monofunctional Alkylators

Anthracyclines

Cytoskeletal disruptors (Taxanes)

Epothilones

Histone Deacetylase Inhibitors

Inhibitors of Topoisomerase I

Inhibitors of Topoisomerase II

Kinase inhibitors

Nucleotide analogs and precursor analogs

Peptide antibiotics

Platinum-based agents

Retinoids

Vinca alkaloids and derivatives

Chemotherapeutic Agents in Alphabetical Order