Granulomatous angiitis: Difference between revisions
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** Variable inflammatory infiltrate( neutrophils , lymphocytes, epitheloid appearing histiocytes and multinucleated giant cells) forming granuloma in the wall of the vessel. | ** Variable inflammatory infiltrate( neutrophils , lymphocytes, epitheloid appearing histiocytes and multinucleated giant cells) forming granuloma in the wall of the vessel. | ||
** Ischemic or hemorrhagic changes may be seen in parenchyma distal to the segment involved. | ** Ischemic or hemorrhagic changes may be seen in parenchyma distal to the segment involved. | ||
==Causes== | |||
Exact etiology is obscure. Few associations are established. | |||
* [[Herpes zoster]] | |||
* [[Hodgkin lymphoma]] | |||
==References== | ==References== | ||
Revision as of 00:33, 10 August 2012
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Granulomatous angiitis is an uncommon necrotising vasculitis of unknown cause restricted to vessels of the central nervous system.[1]
Historical Perspective
Cravioto and Feigin defined granulomatous angiitis in 1959.
Pathophysiology
Microscopic Pathology
- It mainly involves small intracerebral vessels.
- Microscopic changes include
- Focal fibrinoid necrosis of the vessel wall
- Variable inflammatory infiltrate( neutrophils , lymphocytes, epitheloid appearing histiocytes and multinucleated giant cells) forming granuloma in the wall of the vessel.
- Ischemic or hemorrhagic changes may be seen in parenchyma distal to the segment involved.
Causes
Exact etiology is obscure. Few associations are established.