Apolipoprotein C2

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Apolipoprotein C2 or Apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene.

The protein encoded by this gene is secreted in plasma where it is a component of very low density lipoproteins and chylomicrons. This protein activates the enzyme lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.

Related Chapters

• Apolipoprotein C

References

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• Fojo SS, Beisiegel U, Beil U; et al. (1988). "Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency". J. Clin. Invest. 82 (5): 1489–94. doi:10.1172/JCI113756. PMC 442713. PMID 3263393.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Connelly PW, Maguire GF, Hofmann T, Little JA (1987). "Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein". Proc. Natl. Acad. Sci. U.S.A. 84 (1): 270–3. doi:10.1073/pnas.84.1.270. PMC 304185. PMID 3467353.CS1 maint: Multiple names: authors list (link)
• Fairwell T, Hospattankar AV, Brewer HB, Khan SA (1987). "Human plasma apolipoprotein C-II: total solid-phase synthesis and chemical and biological characterization". Proc. Natl. Acad. Sci. U.S.A. 84 (14): 4796–800. doi:10.1073/pnas.84.14.4796. PMC 305192. PMID 3474626.CS1 maint: Multiple names: authors list (link)
• Fojo SS, Taam L, Fairwell T; et al. (1986). "Human preproapolipoprotein C-II. Analysis of major plasma isoforms". J. Biol. Chem. 261 (21): 9591–4. PMID 3525527.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Das HK, Jackson CL, Miller DA; et al. (1987). "The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron". J. Biol. Chem. 262 (10): 4787–93. PMID 3558370.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Connelly PW, Maguire GF, Little JA (1988). "Apolipoprotein CIISt. Michael. Familial apolipoprotein CII deficiency associated with premature vascular disease". J. Clin. Invest. 80 (6): 1597–606. doi:10.1172/JCI113246. PMC 442428. PMID 3680515.CS1 maint: Multiple names: authors list (link)
• Baggio G, Manzato E, Gabelli C; et al. (1986). "Apolipoprotein C-II deficiency syndrome. Clinical features, lipoprotein characterization, lipase activity, and correction of hypertriglyceridemia after apolipoprotein C-II administration in two affected patients". J. Clin. Invest. 77 (2): 520–7. doi:10.1172/JCI112332. PMC 423374. PMID 3944267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Menzel HJ, Kane JP, Malloy MJ, Havel RJ (1986). "A variant primary structure of apolipoprotein C-II in individuals of African descent". J. Clin. Invest. 77 (2): 595–601. doi:10.1172/JCI112342. PMC 423392. PMID 3944271.CS1 maint: Multiple names: authors list (link)
• Sharpe CR, Sidoli A, Shelley CS; et al. (1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Res. 12 (9): 3917–32. doi:10.1093/nar/12.9.3917. PMC 318799. PMID 6328445.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jackson CL, Bruns GA, Breslow JL (1984). "Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII". Proc. Natl. Acad. Sci. U.S.A. 81 (10): 2945–9. doi:10.1073/pnas.81.10.2945. PMC 345197. PMID 6328478.CS1 maint: Multiple names: authors list (link)