Klinefelter's syndrome: Difference between revisions
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A [[karyotype]] is used to confirm the diagnosis. In this procedure, a small blood sample is drawn. [[White blood cell]]s are then separated from the sample, mixed with [[Growth medium|tissue culture medium]], incubated, and checked for chromosomal abnormalities, such as an extra X chromosome. | A [[karyotype]] is used to confirm the diagnosis. In this procedure, a small blood sample is drawn. [[White blood cell]]s are then separated from the sample, mixed with [[Growth medium|tissue culture medium]], incubated, and checked for chromosomal abnormalities, such as an extra X chromosome. | ||
The following tests may be performed: | |||
*[[Semen]] count | |||
*[[Serum]] [[estradiol]] levels (a type of [[estrogen]]) | |||
*[[Serum]] [[follicle stimulating hormone]] | |||
*[[Serum]] [[luteinizing hormone]] | |||
*[[Serum]] [[testosterone]] | |||
==Treatment== | ==Treatment== | ||
Revision as of 14:44, 14 August 2012
| Klinefelter's syndrome | |
 | |
|---|---|
| ICD-10 | Q98.0-Q98.4 |
| ICD-9 | 758.7 |
| DiseasesDB | 7189 |
| MedlinePlus | 000382 |
| MeSH | D007713 |
For patient information click here
- Not to be confused with XYY syndrome or XXX syndrome.
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: 47XXY; XXY syndrome.
Overview
Klinefelter's syndrome is a condition caused by a chromosome aneuploidy. Affected males have an extra X sex chromosome. The principal effects are development of small testicles and reduced fertility. A variety of other physical and behavioral differences and problems are common, though severity varies and many boys and men with the condition have few detectable symptoms. Because of the extra chromosome, individuals with the condition are usually referred to as "XXY Males", or "47, XXY Males".[1]
Historical Perspective
It is named after Dr. Harry Klinefelter, an endocrinologist at Massachusetts General Hospital, Boston, Massachusetts, who first described it in 1942.[2]
The first published report of a man with a 47,XXY karyotype was by Patricia A. Jacobs and Dr. J.A. Strong at Western General Hospital in Edinburgh, Scotland in 1959.[3] This karyotype was found in a 24-year-old man who had signs of Klinefelter's syndrome. Dr. Jacobs described her discovery of this first reported human or mammalian chromosome aneuploidy in her 1981 William Allan Memorial Award address.[4]
Pathophysiology
Genetics
The extra X chromosome is retained because of a nondisjunction event during meiosis (sex cell division).
In mammals with more than one X chromosome, the genes on all but one X chromosome are not expressed; this is known as X inactivation. This happens in XXY males as well as normal XX females.[5] A few genes located in the pseudoautosomal regions, however, have corresponding genes on the Y chromosome and are capable of being expressed.[6] These triploid genes in XXY males may be responsible for symptoms associated with Klinefelter's syndrome.
Variations
The 48, XXYY (male) syndrome occurs 1 in 17,000 births and has traditionally been considered to be a variation of Klinefelter's syndrome. XXYY is no longer generally considered a variation of KS, although it has not yet been assigned an ICD-9 code.
Males with Klinefelter syndrome may have a mosaic 47,XXY/46,XY constitutional karyotype and varying degrees of spermatogenic failure. Mosaicism 47,XXY/46,XX with clinical features suggestive of Klinefelter syndrome is very rare. Thus far, only about 10 cases have been described in literature.[7]
Associated Conditions
Causes
The extra X chromosome is retained because of a nondisjunction event during meiosis (sex cell division).
Differentiating Klinefelter's syndrome from other Diseases
Epidemiology and Demographics
It is the second most common extra chromosome condition. The condition exists in roughly 1 out of every 500 males.[8]
Natural History, Complications and Prognosis
Complications
In these patients, GSTs usually contain nonseminomatous elements, present at an earlier age, and seldom are testicular in location.
The syndrome increases the risk of:
- Attention-deficit hyperactivity disorder
- Autoimmune disorders such as lupus, rheumatoid arthritis, and Sjogren syndrome
- Breast cancer
- Depression
- Dyslexia
- 50 times greater risk of extragonadal germ cell tumor (a rare tumor)[9]
- Learning disabilities, despite normal or high IQ
- Lung disease
- Osteoporosis
- Varicose veins
Enlarged teeth with a thinning surface (taurodontism) is very common in Klinefelter's syndrome. It can be diagnosed by dental x-rays.
Prognosis
- Most patients have a normal, productive life.
Diagnosis
History
Symptoms
Affected males are almost always effectively sterile, although advanced reproductive assistance is sometimes possible.[10] Some degree of language learning impairment may be present,[11] and neuropsychological testing often reveals deficits in executive functions[12]. In adults, possible characteristics vary widely and include little to no signs of affectedness, a lanky, youthful build and facial appearance, or a rounded body type with some degree of gynecomastia (increased breast tissue).[13] Gynecomastia is present to some extent in about a third of affected individuals, a slightly higher percentage than in the XY population, but only about 10% of XXY males' gynecomastia is noticeable enough to require surgery.[14]
The term "hypogonadism" in XXY symptoms is often misinterpreted to mean "small testicles" or "small penis". In fact, it means decreased testicular hormone/endocrine function. Because of this hypogonadism, patients will often have a low serum testosterone level but high serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.[15] Despite this misunderstanding of the term, however, it is true that XXY men often also have "microorchidism" (i.e. small testicles).[15]
The more severe end of the spectrum of symptom expression is also associated with an increased risk of germ cell tumors, breast cancer,[16] and osteoporosis,[8] risks shared to varying degrees[17] with females. Additionally, medical literature shows some individual case studies of Klinefelter's syndrome coexisting with other disorders, such as pulmonary disease, varicose veins, diabetes mellitus, and rheumatoid arthritis, but possible correlations between Klinefelter's and these other conditions are not well characterized or understood.
In contrast to these potentially increased risks, it is currently thought that rare X-linked recessive conditions occur even less frequently in XXY males than in normal XY males, since these conditions are transmitted by genes on the X chromosome, and people with two X chromosomes are typically only carriers rather than affected by these X-linked recessive conditions.
There are many variances within the XXY population, just as in the most common 46,XY population. While it is possible to characterise 47,XXY males with certain body types, that in itself should not be the method of identification as to whether or not someone has 47,XXY. The only reliable method of identification is karyotype testing.
Physical Examination
Appearance of the Patient
Vital Signs
Skin
Head
Eyes
Ear
Nose
Throat
Heart
Lungs
Abdomen
Extremities
Neurologic
Genitals
Other
Laboratory Findings
A karyotype is used to confirm the diagnosis. In this procedure, a small blood sample is drawn. White blood cells are then separated from the sample, mixed with tissue culture medium, incubated, and checked for chromosomal abnormalities, such as an extra X chromosome.
The following tests may be performed:
- Semen count
- Serum estradiol levels (a type of estrogen)
- Serum follicle stimulating hormone
- Serum luteinizing hormone
- Serum testosterone
Treatment
The genetic variation is irreversible, but its symptoms can be altered or treated in a number of ways, including testosterone treatment and other therapies.
Testosterone therapy may be prescribed. This can help:
- Grow body hair
- Improve appearance of muscles
- Improve concentration
- Improve mood and self esteem
- Increase energy and sex drive
- Increase strength
Most men with this syndrome are not able to father children. However, some men have been able to have children. An infertility specialist may be able to help.
Inadequately treated hypogonadism in Klinefelter syndrome increases recognized psychosocial morbidity.[18] At least one study indicates that planned and timed support should be provided for young men with Klinefelter syndrome, to ameliorate current poor psychosocial outcomes.[18]
References
- ↑ Bock, Robert (1993 Aug). "Understanding Klinefelter Syndrome: A Guide for XXY Males and Their Families" (HTML). NIH Pub. No. 93-3202. Office of Research Reporting, NICHD. Retrieved 2007-04-07. Unknown parameter
|month=ignored (help); Check date values in:|date=(help) - ↑ Klinefelter, HF Jr; Reifenstein, EC Jr; Albright (1942), "Syndrome characterized by gynecomastia, aspermatogenesis without a-Leydigism and increased excretion of follicle-stimulating hormone.", J Clin Endocrinol Metab, 2: 615–624, PMID too early to be indexed ''too early to be indexed'' Check
|pmid=value (help). Klinefelter, HF (1986), "Klinefelter's syndrome: historical background and development.", South Med J, 79 (45): 1089–1093, PMID 3529433 talks about the history of the development of the literature. - ↑ Jacobs PA, Strong JA (1959). "A case of human intersexuality having a possible XXY sex-determining mechanism". Nature. 183 (4657): 302–3. doi:10.1038/183302a0. PMID 13632697. Unknown parameter
|month=ignored (help) - ↑ Jacobs PA (1982). "The William Allan Memorial Award address: human population cytogenetics: the first twenty-five years". Am J Hum Genet. 34 (5): 689–98. PMID 6751075. Unknown parameter
|month=ignored (help) - ↑ Chow J, Yen Z, Ziesche S, Brown C (2005). "Silencing of the mammalian X chromosome". Annu Rev Genomics Hum Genet 6: 69-92. PMID 16124854
- ↑ Blaschke RJ, Rappold G (2006). The pseudoautosomal regions, SHOX and disease. Curr Opin Genet Dev. Jun; 16:233-9. PMID 16650979
- ↑ Velissariou V, Christopoulou S, Karadimas C, Pihos I, Kanaka-Gantenbein C, Kapranos N, Kallipolitis G, Hatzaki A. "Rare XXY/XX mosaicism in a phenotypic male with Klinefelter syndrome: case report". Eur J Med Genet 2006 July - August;49(4):331-337. PMID 16829354
- ↑ 8.0 8.1 "Klinefelter Syndrome" (HTML). Health Information. National Institute of Health and Human Development. 2007-02-19. Retrieved 2007-03-24. Check date values in:
|date=(help) and "Klinefelter syndrome" (HTML). Genetics Home Reference. National Library of Medicine. 2006. Retrieved 2007-03-24. both provide statistical estimates. - ↑ Mediastinal germ cell tumor in a child with precocious puberty and Klinefelter syndrome. Gregory G. Bebb, Frederic W. Grannis, Jr, Isaac B. Paz, Marilyn L. Slovak, Robert Chilcote. Ann Thorac Surg 1998;66:547-548. [http://ats.ctsnetjournals.org/cgi/content/abstract/66/2/547 Online}
- ↑ Denschlag, Dominik, MD; Clemens, Tempfer, MD; Kunze, Myriam, MD; Wolff, Gerhard, MD; Keck, Christoph, MD (October 2004), "Assisted reproductive techniques in patients with Klinefelter syndrome: A critical review", Fertility and Sterility, 82 (4): 775–779, doi:10.1016/j.fertnstert.2003.09.085
- ↑ Graham, JM Jr; Bashir, AS; Stark, RE; Silbert, A; Walzer, S (June 1988), "Oral and written language abilities of XXY boys: implications for anticipatory guidance.", Pediatrics, 81 (6): 795–806, PMID 3368277
- ↑ Boone et al: (2001), "Neuropsychological profiles of adults with Klinefelter syndrome" in Journal of International Neuropsychological Society, #7, p 446-456.
- ↑ Abstract of Klinefelter, HF (1986), "Klinefelter's syndrome: historical background and development.", South Med J, 79 (9): 1089–1093, PMID 3529433 provides information on microorchidism (small testes), hypogonadism (infertility/sterility and androgen hormone function) and gynecomastia. Bock, Robert (1993 Aug). "Understanding Klinefelter Syndrome: A Guide for XXY Males and Their Families" (HTML). NIH Pub. No. 93-3202. Office of Research Reporting, NICHD. Retrieved 2007-03-28. Unknown parameter
|month=ignored (help); Check date values in:|date=(help) offers substantive information about body type and appearance until a more rigorous source is found/supplied. - ↑ Bock, Robert (1993 Aug). "Understanding Klinefelter Syndrome: A Guide for XXY Males and Their Families, Adolescence section" (HTML). NIH Pub. No. 93-3202. Office of Research Reporting, NICHD. Retrieved 2007-03-29. Unknown parameter
|month=ignored (help); Check date values in:|date=(help) describes statistical occurrence of gynecomastia and surgical treatment. - ↑ 15.0 15.1 Leask, Kathryn (October 2005). "Klinefelter syndrome" (HTML). National Library for Health, Specialist Libraries, Clinical Genetics. National Library for Health. Retrieved 2007-04-07.
- ↑ Hultborn, R; Hanson, C; Kopf, I; Verbiene, I; Warnhammar, E; Weimarck, A (1997 Nov-Dec), "Prevalence of Klinefelter's syndrome in male breast cancer patients.", Anticancer Res., 17 (6D): 4293–4297, PMID 9494523 Check date values in:
|date=(help) - ↑ For instance, while Hultborn, R; Hanson, C; Kopf, I; Verbiene, I; Warnhammar, E; Weimarck, A (1997 Nov-Dec), "Prevalence of Klinefelter's syndrome in male breast cancer patients.", Anticancer Res., 17 (6D): 4293–4297, PMID 9494523 Check date values in:
|date=(help) shows a 50-fold increased risk of developing breast cancer versus normal males, study of the SEER Cancer Statistics Review (CSR) databases available at the National Cancer Institute reveal that female relative risk of breast cancer incidence compared to normal males is around a 100 to 200-fold increase, which indicates XXY males may not be as much at risk statistically as normal females are. - ↑ 18.0 18.1 Simm PJ, Zacharin MR. "The psychosocial impact of Klinefelter syndrome--a 10 year review". J Pediatr Endocrinol Metab 2006 Apr;19(4):499-505. PMID 16759035
Related Chapters
- Intersexuality
- Mosaic (genetics)
- Triple X syndrome
- Turner syndrome
- XXYY syndrome
- XYY syndrome
- True hermaphroditism
Template:Chromosomal abnormalities
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