'''Sodium fluoride''' is an [[ionic compound]] with the formula NaF. This colourless solid is the main source of the [[fluoride]] ion in diverse applications. NaF is less expensive and less [[hygroscopy|hygroscopic]] than KF, but otherwise the potassium salt is more widely used.
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|useInPregnancyFDA=* '''Pregnancy Category'''
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
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|administration=* Oral
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|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
==Chemical structure and properties==
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NaF crystallizes in the [[sodium chloride]] motif where both Na<sup>+</sup> and F<sup>−</sup> occupy octahedral coordination sites.<ref>Wells, A.F. (1984) Structural Inorganic Chemistry, Oxford: Clarendon Press. ISBN 0-19-855370-6.</ref>
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It is usually used as a reagent for the synthesis of fluorides. Representative substrates include electrophilic chlorides including acyl chlorides, sulfur chlorides, and phosphorus chloride.<ref>Halpern, D. F. “Sodium Fluoride” Encyclopedia of Reagents for Organic Synthesis, 2001, John Wiley & Sons. DOI: 10.1002/047084289X.rs071.</ref> Like other fluorides, NaF finds use in desilylation in [[organic synthesis]].
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|lookAlike=* A® — B®<ref name="www.ismp.org">{{Cite web | last = | first = | title = http://www.ismp.org | url = http://www.ismp.org | publisher = | date = }}</ref>
==Uses==
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[[Image:Sodium fluoride tablets.jpg|thumb|left|Sodium fluoride is sold in tablets for cavity prevention.]]
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Fluoride salts are used widely to enhance the strength of teeth by the formation of [[fluoroapatite]], a naturally occurring component of tooth enamel. In the US, NaF was once used to [[Water fluoridation|fluoridate]] drinking water but its use has been displaced by hexafluorosilicic acid (H<sub>2</sub>SiF<sub>6</sub>) or its sodium salt (Na<sub>2</sub>SiF<sub>6</sub>). [[Toothpaste]] often contains sodium fluoride to prevent [[dental caries|cavities]].
Sodium fluoride was also used as an antibiotic, as rat poison, and in ceramics.
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==See also==
*[[Fluorine]]
*[[Water fluoridation]]
*[[Fluoride poisoning]]
*[[Caries]]
*[[Osteoporosis]]
*[[Insecticide]]
*Cryolite
*Light metals
==References==
<references/>
==External links==
*[http://www.chemistry.org/portal/a/c/s/1/acsdisplay.html?DOC=HomeMolecule%5Carchive%5Cmotw_sodiumfluoride_arch.html Sodium Fluoride] at chemistry.org (American Chemical Society)
*[http://www.scorecard.org/chemical-profiles/summary.tcl?edf_substance_id=7681-49-4 Chemical Profile for Sodium Fluoride (CAS Number: 7681-49-4)] at Scorecard, the pollution information site
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Black Box Warning
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See full prescribing information for complete Boxed Warning.
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Overview
Sodium fluoride is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
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There is limited information regarding Off-Label Guideline-Supported Use of Sodium fluoride in adult patients.
Non–Guideline-Supported Use
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There is limited information regarding Off-Label Non–Guideline-Supported Use of Sodium fluoride in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Condition1
Dosing Information
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There is limited information regarding FDA-Labeled Use of Sodium fluoride in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
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Developed by:
Class of Recommendation:
Strength of Evidence:
Dosing Information
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There is limited information regarding Off-Label Guideline-Supported Use of Sodium fluoride in pediatric patients.
Non–Guideline-Supported Use
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Dosing Information
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There is limited information regarding Off-Label Non–Guideline-Supported Use of Sodium fluoride in pediatric patients.
Contraindications
Condition1
Warnings
ConditionName:
See full prescribing information for complete Boxed Warning.
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Content
Description
Precautions
Description
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Sodium fluoride in the drug label.
Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Sodium fluoride in the drug label.
