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Revision as of 20:19, 7 October 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2].

Synonyms and keywords:: Rose gardener's.

Overview

Sporotrichosis (also known as "Rose gardener's disease"^[1]) is a disease caused by the infection of the fungus Sporothrix schenckii.^[2] This fungal disease usually affects the skin, although other rare forms can affect the lungs, joints, bones, and even the brain. Because roses can spread the disease, it is one of a few diseases referred to as rose-thorn or rose-gardeners' disease.^[3]

Because S. schenckii is naturally found in soil, hay, sphagnum moss, and plants, it usually affects farmers, gardeners, and agricultural workers.^[2] It enters through small cuts and abrasions in the skin to cause the infection. In case of sporotrichosis affecting the lungs, the fungal spores enter through the respiratory pathways. Sporotrichosis can also be acquired from handling cats with the disease; it is an occupational hazard for veterinarians.

Sporotrichosis progresses slowly - the first symptoms may appear 1 to 12 weeks (average 3 weeks) after the initial exposure to the fungus. Serious complications can also develop in patients who have a compromised immune system.

Forms and symptoms

Cutaneous or skin sporotrichosis

This is the most common form of this disease. Symptoms of this form include nodular lesions or bumps in the skin, at the point of entry and also along lymph nodes and vessels. The lesion starts off small and painless, and ranges in color from pink to purple. Left untreated, the lesion becomes larger and look similar to a boil and more lesions will appear, until a chronic ulcer develops.

Usually, cutaneous sporotrichosis lesions occur in the finger, hand, and arm.

Pulmonary sporotrichosis

This rare form of the disease occur when S. schenckii spores are inhaled. Symptoms of pulmonary sporotrichosis include productive coughing, nodules and cavitations of the lungs, fibrosis, and swollen hilar lymph nodes. Patients with this form of sporotrichosis are susceptible to developing tuberculosis and pneumonia

Disseminated sporotrichosis

When the infection spreads from the primary site to secondary sites in the body, the disease develops into a rare and critical form called disseminated sporotrichosis. The infection can spread to joints and bones (called osteoarticular sporotrichosis) as well as the central nervous system and the brain (called sporotrichosis meningitis).

The symptoms of disseminated sporotrichosis include weight loss, anorexia, and appearance of bony lesions.

Sporotrichosis in animals

Sporotrichosis can be diagnosed in domestic and wild mammals. In veterinary medicine it is most frequently seen in cats and horses. Cats have a particularly severe form of cutaneous sporotrichosis and also can serve as a source of zoonotic infection to persons who handle them and are exposed to exudate from skin lesions.

Diagnosis

Sporotrichosis is a chronic disease with slow progression and often subtle symptoms. It is difficult to diagnose, as many other diseases share similar symptoms and therefore must be ruled out.

Patients with sporotrichosis will have antibody against the fungus S. schenckii, however, due to variability in sensitivity and specificity, it may not be a reliable diagnosis for this disease. The confirming diagnosis remains culturing the fungus from the skin, sputum, synovial fluid, and cerebrospinal fluid.

Cats with sporotrichosis are unique in that the exudate from their lesions may contain numerous organisms. This makes cytological evaluation of exudate a valuable diagnostic tool in this species. Exudate is pyogranulomatous and phagocytic cells may be packed with yeast forms. These are variable in size, but many are cigar-shaped.

Prevention

The majority of sporotrichosis cases occur when the fungus is introduced through a cut or puncture in the skin while handling vegetation containing the fungal spores. Prevention of this disease includes wearing long sleeves and gloves while working with soil, hay bales, rose bushes, pine seedlings, and sphagnum moss.

Physical examination

Gallery

Skin

Head

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

Extremities

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

Trunk

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>

Treatment

Treatment of sporotrichosis depends on the severity and location of the disease. The following are treatment options for this condition:^[4]

Saturated potassium iodide solution

Although its mechanism is unknown, application of potassium iodide in droplet form can cure cutaneous sporotrichosis. This usually requires 3 to 6 months of treatment.

Itraconazole (Sporanox) and fluconazole

These are antifungal drugs. Itraconazole is currently the drug of choice and is significantly more effective than fluconazole. Fluconazole should be reserved for patients who cannot tolerate itraconazole.

Amphotericin B

This antifungal medication is delivered intravenously. Many patients, however, cannot tolerate Amphotericin B due to its potential side effects of fever, nausea, and vomiting.

Lipid formulations of amphotericin B are usually recommended instead of amphotericin B deoxycholate because of a better adverse-effect profile. Amphotericin B can be used for severe infection during pregnancy. For children with disseminated or severe disease, amphotericin B deoxycholate can be used initially, followed by itraconazole.^[5]

In case of sporotrichosis meningitis, the patient may be given a combination of Amphotericin B and 5-fluorocytosine/Flucytosine.

Newer triazoles

Several studies have shown that posaconazole has in vitro activity similar to that of amphotericin B and itraconazole; therefore, it shows promise as an alternative therapy. However, voriconazole susceptibility varies. Because the correlation between in vitro data and clinical response has not been demonstrated, there is insufficient evidence to recommend either posaconazole or voriconazole for treatment of sporotrichosis at this time.^[5]

Surgery

In cases of bone infection and cavitatory nodules in the lungs, surgery may be necessary.

References

↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
↑ ^2.0 ^2.1 Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 654–6. ISBN 0-8385-8529-9.
↑ Volk T. "Sporothrix schenckii, cause of Rose-picker's Disease". Tom Volk's Fungus of the Month. Retrieved 2007-06-16.
↑ Lortholary O, Denning DW, Dupont B (1999). "Endemic mycoses: a treatment update". J. Antimicrob. Chemother. 43 (3): 321–31. doi:10.1093/jac/43.3.321. PMID 10223586.
↑ ^5.0 ^5.1 Hogan BK, Hospenthal DR. Update on the therapy for sporotrichosis. Drug Benefit Trends. 2010;22:49-52.

Complications

Cutaneous lesions can become superinfected with bacteria, resulting in cellulitis.

[Bolognia-1] Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.

[Sherris-2] 2.0 ^2.1 Ryan KJ, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. pp. 654–6. ISBN 0-8385-8529-9.

[3] Volk T. "Sporothrix schenckii, cause of Rose-picker's Disease". Tom Volk's Fungus of the Month. Retrieved 2007-06-16.

[4] Lortholary O, Denning DW, Dupont B (1999). "Endemic mycoses: a treatment update". J. Antimicrob. Chemother. 43 (3): 321–31. doi:10.1093/jac/43.3.321. PMID 10223586.

[dbt.consultantlive.com-5] 5.0 ^5.1 Hogan BK, Hospenthal DR. Update on the therapy for sporotrichosis. Drug Benefit Trends. 2010;22:49-52.

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
-{{DiseaseDisorder infobox |
+__NOTOC__
-  Name           = Sporotrichosis |
-  Image          = Feline sporotrichosis 4.jpg |
-  Caption        = Cytologic preparation from a case of feline sporotrichosis; phagocytic cells show numerous variably-shaped yeast forms within |
-  ICD10          = {{ICD10|B|42||b|35}} |
-  ICD9           = {{ICD9|117.1}} |
-  ICDO           = |
-  OMIM           = |
-  DiseasesDB     = 29797 |
-  MedlinePlus    = |
-  eMedicineSubj  = med |
-  eMedicineTopic = 2161 |
-  eMedicine_mult = {{eMedicine2|derm|400}} |
-  MeshID         = D013174 |
-}}
 {{SI}}
-{{CMG}}
+{{CMG}}; {{AE}} {{JH}}.
+{{SK}}: Rose gardener's.
+==Overview==
+'''Sporotrichosis''' (also known as "Rose gardener's disease"<ref name="Bolognia">{{cite book |author=Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages= |isbn=1-4160-2999-0 |oclc= |doi= |accessdate=}}</ref>) is a disease caused by the infection of the [[fungus]] ''[[Sporothrix schenckii]]''.<ref name=Sherris>{{cite book | author = Ryan KJ, Ray CG (editors) | title = Sherris Medical Microbiology | edition = 4th | pages = 654–6 | publisher = McGraw Hill | year = 2004 | isbn = 0-8385-8529-9 }}</ref>  This fungal disease usually affects the [[skin]], although other rare forms can affect the [[lung]]s, [[joint]]s, [[bone]]s, and even the [[brain]].  Because [[rose]]s can spread the disease, it is one of a few diseases referred to as ''rose-thorn'' or ''rose-gardeners' disease''.<ref>{{cite web | author = Volk T | title = ''Sporothrix schenckii'', cause of Rose-picker's Disease | work = Tom Volk's Fungus of the Month | url = http://botit.botany.wisc.edu/toms_fungi/feb2003.html | accessdate = 2007-06-16}}</ref>
-'''Sporotrichosis''' is a disease caused by the infection of the [[fungus]] ''[[Sporothrix schenckii]]''.<ref name=Sherris>{{cite book | author = Ryan KJ, Ray CG (editors) | title = Sherris Medical Microbiology | edition = 4th ed. | pages = p. 654–6 | publisher = McGraw Hill | year = 2004 | isbn = 0838585299 }}</ref>  This fungal disease usually affects the [[skin]], although other rare forms can affect the [[lung]]s, [[joint]]s, [[bone]]s, and even the [[brain]].  Because roses can spread the disease, it is one of a few diseases referred to as ''rose-thorn'' or ''rose-gardeners' disease''.<ref>{{cite web | author = Volk T | title = ''Sporothrix schenckii'', cause of Rose-picker's Disease | work = Tom Volk's Fungus of the Month | url = http://botit.botany.wisc.edu/toms_fungi/feb2003.html | accessdate = 2007-06-16}}</ref>
+Because ''S. schenckii'' is naturally found in soil, [[hay]], [[sphagnum moss]], and plants, it usually affects [[farmer]]s, gardeners, and agricultural workers.<ref name=Sherris /> It enters through small cuts and abrasions in the skin to cause the infection.  In case of sporotrichosis affecting the lungs, the fungal spores enter through the respiratory pathways. Sporotrichosis can also be acquired from handling cats with the disease; it is an occupational hazard for veterinarians.
-Because ''S. schencki'' is naturally found in soil, [[hay]], [[sphagnum moss]], and plants, it usually affects [[farmer]]s, gardeners, and agricultural workers.<ref name=Sherris /> It enters through small cuts and abrasions in the skin to cause the infection.  In case of sporotrichosis affecting the lungs, the fungal spores enter through the respiratory pathways. Sporotrichosis can also be acquired from handling cats with the disease; it is an occupational hazard for veterinarians.
 Sporotrichosis progresses slowly - the first symptoms may appear 1 to 12 weeks (average 3 weeks) after the initial exposure to the fungus.  Serious complications can also develop in patients who have a compromised [[immune system]].
-==Forms and symptoms of sporotrichosis==
+==Forms and symptoms==
 * ''Cutaneous or skin sporotrichosis''
-:This is the most common form of this disease.  Symptoms of this form includes nodular [[lesion]]s or bumps in the skin, at the point of entry and also along [[lymph]] nodes and vessels.  The lesion starts off small and painless, and ranges in color from pink to purple.  Left untreated, the lesion becomes larger and look similar to a [[boil]] and more lesions will appear, until a chronic [[ulceration|ulcer]] develops.
+:This is the most common form of this disease.  Symptoms of this form include nodular [[lesion]]s or bumps in the skin, at the point of entry and also along [[lymph]] nodes and vessels.  The lesion starts off small and painless, and ranges in color from pink to purple.  Left untreated, the lesion becomes larger and look similar to a [[boil]] and more lesions will appear, until a chronic [[Ulcer (dermatology)|ulcer]] develops.
 :Usually, cutaneous sporotrichosis lesions occur in the finger, hand, and arm.
 *''Pulmonary sporotrichosis''
-:This rare form of the disease occur when ''S. schenckii'' spores are inhaled.  Symptoms of [[pulmonary]] sporotrichosis include productive [[cough]]ing, nodules and cavitations of the lungs, [[fibrosis]], and swollen [[hilar]] [[lymph node]]s.  Patients with this form of sporotrichosis are susceptible to developing [[tuberculosis]] and [[pneumonia]]
+:This rare form of the disease occur when ''S. schenckii'' spores are inhaled.  Symptoms of [[pulmonary]] sporotrichosis include productive [[cough]]ing, nodules and cavitations of the lungs, [[fibrosis]], and swollen [[Hilum of lung|hilar]] [[lymph node]]s.  Patients with this form of sporotrichosis are susceptible to developing [[tuberculosis]] and [[pneumonia]]
 *''Disseminated sporotrichosis''
@@ Line 40: / Line 27: @@
 ==Sporotrichosis in animals==
-[[Image:Feline sporotrichosis 3.jpg|thumb|left|Ulcerative skin disease in a cat with Sporotrichosis; a cat with this disease must be handled with caution as this form can be contagious to other animals and to man]]Sporotrichosis can be diagnosed in domestic and wild mammals. In veterinary medicine it is most frequenttly seen in cats and horses.  Cats have a particularly severe form of cutaneous sporotrichosis and also can serve as a source of zoonotic infection to persons who handle them and are exposed to exudate from skin lesions.
+Sporotrichosis can be diagnosed in domestic and wild mammals. In veterinary medicine it is most frequently seen in cats and horses.  Cats have a particularly severe form of cutaneous sporotrichosis and also can serve as a source of zoonotic infection to persons who handle them and are exposed to exudate from skin lesions.
 ==Diagnosis==
@@ Line 50: / Line 37: @@
 ==Prevention==
-The majority of sporotrichosis cases occur when the fungus is introduced through a cut or puncture in the skin while handling vegetations containing the fungal spores.  Prevention of this disease includes wearing long sleeves and gloves while working with soil, hay bales, rose bushes, pine seedlings, and sphagnum moss.
+The majority of sporotrichosis cases occur when the fungus is introduced through a cut or puncture in the skin while handling vegetation containing the fungal spores.  Prevention of this disease includes wearing long sleeves and gloves while working with soil, hay bales, rose bushes, pine seedlings, and sphagnum moss.
+==Physical examination==
+===Gallery===
+====Skin====
+=====Head=====
+<gallery>
+Image: Sporotrichosis_01.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+Image: Sporotrichosis_02.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+</gallery>
+=====Extremities=====
+<gallery>
+Image: Sporotrichosis_03.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+Image: Sporotrichosis_04.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+Image: Sporotrichosis_05.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+</gallery>
+=====Trunk=====
+<gallery>
+Image: Sporotrichosis_06.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+Image: Sporotrichosis_07.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+Image: Sporotrichosis_08.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+Image: Sporotrichosis_09.jpeg| Sporotrichosis. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12  With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=429>
+</gallery>
 ==Treatment==
-Treatment of sporotrichosis depends on the severity and location of the disease.  The following are treatment options for this condition:<ref>{{cite journal |author=Lortholary O, Denning DW, Dupont B |title=Endemic mycoses: a treatment update |journal=J. Antimicrob. Chemother. |volume=43 |issue=3 |pages=321-31 |year=1999 |pmid=10223586 |url=http://jac.oxfordjournals.org/cgi/content/full/43/3/321}}</ref>
+Treatment of sporotrichosis depends on the severity and location of the disease.  The following are treatment options for this condition:<ref>{{cite journal |author=Lortholary O, Denning DW, Dupont B |title=Endemic mycoses: a treatment update |journal=J. Antimicrob. Chemother. |volume=43 |issue=3 |pages=321–31 |year=1999 |pmid=10223586 |url=http://jac.oxfordjournals.org/cgi/content/full/43/3/321 |doi=10.1093/jac/43.3.321}}</ref>
 *Saturated [[potassium iodide]] solution
-:Although its mechanism is unknown, oral application of potassium iodide in droplet form can cure cutaneous sporotrichosis.  This usually requires 3 to 6 months of treatment.
+:Although its mechanism is unknown, application of potassium iodide in droplet form can cure cutaneous sporotrichosis.  This usually requires 3 to 6 months of treatment.
 *[[Itraconazole]] (Sporanox) and [[fluconazole]]
-:These are [[antifungal]] drugs.  Itraconazole are the preferred medicine, although patients that cannot tolerate it can be given fluconazole.
+:These are [[Antifungal medication|antifungal]] drugs.  Itraconazole is currently the drug of choice and is significantly more effective than fluconazole. Fluconazole should be reserved for patients who cannot tolerate itraconazole.
 *[[Amphotericin B]]
 :This antifungal medication is delivered intravenously.  Many patients, however, cannot tolerate Amphotericin B due to its potential side effects of fever, nausea, and vomiting.
+Lipid formulations of amphotericin B are usually recommended instead of amphotericin B deoxycholate because of a better adverse-effect profile. Amphotericin B can be used for severe infection during pregnancy. For children with disseminated or severe disease, amphotericin B deoxycholate can be used initially, followed by itraconazole.<ref name="dbt.consultantlive.com">Hogan BK, Hospenthal DR. [http://dbt.consultantlive.com/display/article/1145628/1545568 Update on the therapy for sporotrichosis]. Drug Benefit Trends. 2010;22:49-52.</ref>
-:In case of sporotrichosis meningitis, the patient may be given a combination of Amphotericin B and [[5-fluorocytosine]].
+:In case of sporotrichosis meningitis, the patient may be given a combination of Amphotericin B and 5-fluorocytosine/[[Flucytosine]].
+*Newer [[triazole]]s
+Several studies have shown that [[posaconazole]] has in vitro activity similar to that of amphotericin B and itraconazole; therefore, it shows promise as an alternative therapy. However, [[voriconazole]] susceptibility varies. Because the correlation between in vitro data and clinical response has not been demonstrated, there is insufficient evidence to recommend either posaconazole or voriconazole for treatment of sporotrichosis at this time.<ref name="dbt.consultantlive.com"/>
 *[[Surgery]]
 :In cases of bone infection and cavitatory nodules in the lungs, surgery may be necessary.
-==Complications==
-Sporotrichosis can develop into other diseases, including [[cellulitis]], [[sarcoidosis]], and [[tuberculosis]].
 ==References==
-<!-- ---------------------------------------------------------------
+{{Reflist|2}}
-See http://en.wikipedia.org/wiki/Wikipedia:Footnotes for a
-discussion of different citation methods and how to generate
-footnotes using the <ref> & </ref> tags and the {{Reflist}} template
--------------------------------------------------------------------- -->
-{{Reflist}}
-==External links==
+==Complications==
-* [http://www.healthinplainenglish.com/health/infectious_diseases/sporotrichosis/index.htm Sporotrichosis] by Health in Plain English (with pictures)
+Cutaneous lesions can become superinfected with bacteria, resulting in cellulitis.
-* [http://www.cdc.gov/ncidod/dbmd/diseaseinfo/sporotrichosis_g.htm Sporotrichosis] by Centers for Disease Control and Prevention (CDC)
-{{Mycoses}}
-[[Category:Fungal diseases]]
-[[es:Esporotricosis]]
-[[zh:孢子絲菌病]]
-{{WH}}
-{{WS}}