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| {{drugbox
| | #REDIRECT [[Triamterene#Pharmacology]] |
| | IUPAC_name = 6-phenylpteridine-2,4,7-triamine
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| | image = Triamterene_svg.png
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| | CAS_number = 396-01-0
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| | ATC_prefix = C03
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| | ATC_suffix = DB02
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| | ATC_supplemental =
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| | PubChem = 5546
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| | DrugBank = APRD00079
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| | C = 12 | H = 11 | N = 7
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| | molecular_weight = 253.263 g/mol
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| | bioavailability =
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| | protein_bound = 97%
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| | metabolism =
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| | elimination_half-life =
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| | pregnancy_category =
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| | legal_status =
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| | routes_of_administration =
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| }}
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| {{CMG}}
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| ==[[Triamterene (patient information)|For patient information, click here]]==
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| '''Triamterene''' (trade name '''Dyrenium''') is a [[potassium-sparing diuretic]] used in combination with [[thiazide]] diuretics for the treatment of [[hypertension]] and [[edema]]. This medication is best avoided in patients with [[chronic kidney disease]] due to the possibility of [[hyperkalemia]]. People using this drug should use [[salt substitute]] very cautiously.<ref>LoSalt [http://www.losalt.com/docs/lo_salt_web_advice.pdf Advisory Statement] (PDF)</ref>
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| ==Mode of action==
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| Triamterene directly blocks the [[epithelial sodium channel]] (ENaC) on the lumen side of the kidney [[collecting tubule]]. Other [[diuretic]]s cause an increase in the sodium concentrations in the forming urine causing more sodium to enter through ENaC, chasing more [[potassium]] out of the [[principal cell]] and into the forming urine. Blocking ENaC prevents this from happening. [[Amiloride]] works in the same way.
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| ==Side effects==
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| Common [[adverse drug reaction|side effect]]s may include a depletion of [[sodium]], [[folic acid]] and [[calcium]], nausea, vomiting, diarrhea, headache, dizziness, fatigue, and dry mouth. Serious side effects may include heart palpitations, tingling/numbness, fever, chills, sore throat, rash, and back pain. Triamterene can also cause [[kidney stones]] through direct crystallization or by seeding [[calcium oxalate]] stones.
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| == References ==
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| <references/>
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| {{Antihypertensives and diuretics}}
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| [[Category:Potassium-sparing diuretics]]
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| [[Category:Drugs]]
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| {{WikiDoc Help Menu}}
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| {{WikiDoc Sources}}
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| [[de:Triamteren]]
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| [[hr:Triamteren]]
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| [[ja:トリアムテレン]]
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