Psoriasis pathophysiology: Difference between revisions
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Created page with "{{Psoriasis}} {{CMG}} ==Overview== ==Pathophysiology== ===Genetetics=== Around one-third of people with psoriasis report a family history of..." |
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Around one-third of people with psoriasis report a [[family history (medicine)|family history]] of the disease, and researchers have identified genetic [[locus (genetics)|loci]] associated with the condition. Studies of [[twin|monozygotic twins]] suggest a 70% chance of a twin developing psoriasis if the other twin has psoriasis. The [[concordance (genetics)|concordance]] is around 20% for [[twin|dizygotic twins]]. These findings suggest both a genetic predisposition and an environmental response in developing psoriasis.<!-- | Around one-third of people with psoriasis report a [[family history (medicine)|family history]] of the disease, and researchers have identified genetic [[locus (genetics)|loci]] associated with the condition. Studies of [[twin|monozygotic twins]] suggest a 70% chance of a twin developing psoriasis if the other twin has psoriasis. The [[concordance (genetics)|concordance]] is around 20% for [[twin|dizygotic twins]]. These findings suggest both a genetic predisposition and an environmental response in developing psoriasis.<!-- | ||
Revision as of 15:47, 22 August 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Genetics
Around one-third of people with psoriasis report a family history of the disease, and researchers have identified genetic loci associated with the condition. Studies of monozygotic twins suggest a 70% chance of a twin developing psoriasis if the other twin has psoriasis. The concordance is around 20% for dizygotic twins. These findings suggest both a genetic predisposition and an environmental response in developing psoriasis.[1]
References
- ↑ Krueger G, Ellis CN (2005). "Psoriasis--recent advances in understanding its pathogenesis and treatment". J. Am. Acad. Dermatol. 53 (1 Suppl 1): S94–100. doi:10.1016/j.jaad.2005.04.035. PMID 15968269.