Fabry's disease natural history, complications and prognosis: Difference between revisions
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== Natural History [1]{{Cite book}} == | |||
__NOTOC__ | __NOTOC__ | ||
{{Fabry's disease}} | {{Fabry's disease}} | ||
==== Homozygotes ==== | |||
* The symptoms of classic Fabry's disease usually develop in childhood or adolescents , and start with symptoms such as neuropathic pains, angiokeratomas, dyshidrosis, GI symptoms, and etc. | |||
* Without treatment, lifespan of homozygote men will dramatically reduced to fifth decade and the main causes of deaths are renal failure, heart disease or stroke. | |||
==== Heterozygote ==== | |||
* The symptoms of late-onset Fabry's disease in females and atypical variants are accrue in higher ages and are less severe. | |||
* With out treatment, life span of heterozygote females will be at seventh decade and the main causes of death are cardiac dysfunction, cancer and stroke. | |||
==References== | ==References== | ||
{{Reflist | {{Reflist}}[1] 1-903539-03-XFabry, Hermann, et al. Fabry disease : perspectives from 5 years of FOS. Oxford: PharmaGenesis, 2006. Print. | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
Revision as of 08:29, 4 April 2022
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Homozygotes
- The symptoms of classic Fabry's disease usually develop in childhood or adolescents , and start with symptoms such as neuropathic pains, angiokeratomas, dyshidrosis, GI symptoms, and etc.
- Without treatment, lifespan of homozygote men will dramatically reduced to fifth decade and the main causes of deaths are renal failure, heart disease or stroke.
Heterozygote
- The symptoms of late-onset Fabry's disease in females and atypical variants are accrue in higher ages and are less severe.
- With out treatment, life span of heterozygote females will be at seventh decade and the main causes of death are cardiac dysfunction, cancer and stroke.
References
[1] 1-903539-03-XFabry, Hermann, et al. Fabry disease : perspectives from 5 years of FOS. Oxford: PharmaGenesis, 2006. Print.