Amyotrophic lateral sclerosis classification: Difference between revisions
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==Overview== | ==Overview== | ||
ALS is classified into three general groups, '''familial ALS''', '''sporadic ALS''' and '''Guamanian ALS'''. | |||
==Classification== | ==Classification== | ||
* "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors. Of these approximately 10% are linked to a mutation in [[Superoxide dismutase]] (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals. | * "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors. Of these approximately 10% are linked to a mutation in [[Superoxide dismutase]] (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals. | ||
* Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component. | * Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component. | ||
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{{reflist|2}} | {{reflist|2}} | ||
[[Category:Motor neuron disease]] | |||
[[Category:Neurology]] | |||
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{{WS}} | {{WS}} |
Revision as of 21:21, 26 November 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
ALS is classified into three general groups, familial ALS, sporadic ALS and Guamanian ALS.
Classification
- "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors. Of these approximately 10% are linked to a mutation in Superoxide dismutase (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals.
- Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component.
- A third type, called "Guamanian ALS", represents a small cluster of cases concentrated on the Pacific island of Guam.