Ulcerative colitis medical therapy: Difference between revisions
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{{Ulcerative colitis}} | {{Ulcerative colitis}} | ||
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==Medical Therapy== | |||
== Medical Therapy == | |||
{{main|Treatment of ulcerative colitis}} | {{main|Treatment of ulcerative colitis}} | ||
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Standard treatment for ulcerative colitis depends on ''extent of involvement'' and disease ''severity''. The goal is to induce [[Remission (medicine)|remission]] initially with medications, followed by the administration of maintenance medications to prevent a relapse of the disease. The concept of induction of remission and maintenance of remission is very important. The medications used to induce and maintain a remission somewhat overlap, but the treatments are different. Physicians first direct treatment to inducing a remission which involves relief of symptoms and mucosal healing of the lining of the colon and then longer term treatment to maintan the remission. | Standard treatment for ulcerative colitis depends on ''extent of involvement'' and disease ''severity''. The goal is to induce [[Remission (medicine)|remission]] initially with medications, followed by the administration of maintenance medications to prevent a relapse of the disease. The concept of induction of remission and maintenance of remission is very important. The medications used to induce and maintain a remission somewhat overlap, but the treatments are different. Physicians first direct treatment to inducing a remission which involves relief of symptoms and mucosal healing of the lining of the colon and then longer term treatment to maintan the remission. | ||
=== | ===Pharmacotherapies=== | ||
==== Aminosalicylates ==== | ==== Aminosalicylates ==== | ||
[[Sulfasalazine]] has been a major agent in the therapy of mild to moderate UC for over 50 years. In 1977 Mastan S.Kalsi et al determined that 5-aminosalicyclic acid (5-ASA and [[mesalazine]]) was the therapeutically active compound in [[sulfasalazine]]. Since then many 5-ASA compounds have been developed with the aim of maintaining efficacy but reducing the common side effects associated with the sulfapyridine moiety in [[sulfasalazine]].<ref> {{cite web | author=S. Kane |year=2006 | title=Asacol - A Review Focusing on Ulcerative Colitis|url=http://www.touchalimentarydisease.com/articles.cfm?article_id=6364&level=2}}</ref> | [[Sulfasalazine]] has been a major agent in the therapy of mild to moderate UC for over 50 years. In 1977 Mastan S.Kalsi et al determined that 5-aminosalicyclic acid (5-ASA and [[mesalazine]]) was the therapeutically active compound in [[sulfasalazine]]. Since then many 5-ASA compounds have been developed with the aim of maintaining efficacy but reducing the common side effects associated with the sulfapyridine moiety in [[sulfasalazine]].<ref> {{cite web | author=S. Kane |year=2006 | title=Asacol - A Review Focusing on Ulcerative Colitis|url=http://www.touchalimentarydisease.com/articles.cfm?article_id=6364&level=2}}</ref> | ||
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== References == | == References == | ||
{{ | {{Reflist|2}} | ||
{{WH}} | {{WH}} | ||
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[[Category:Primary care]] | |||
[[Category:Autoimmune diseases]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Inflammations]] | |||
[[Category:Conditions diagnosed by stool test]] | |||
[[Category:Abdominal pain]] | |||
[[Category:Signs and symptoms]] | |||
[[Category:Needs overview]] | |||
Revision as of 16:26, 15 April 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Medical Therapy
Standard treatment for ulcerative colitis depends on extent of involvement and disease severity. The goal is to induce remission initially with medications, followed by the administration of maintenance medications to prevent a relapse of the disease. The concept of induction of remission and maintenance of remission is very important. The medications used to induce and maintain a remission somewhat overlap, but the treatments are different. Physicians first direct treatment to inducing a remission which involves relief of symptoms and mucosal healing of the lining of the colon and then longer term treatment to maintan the remission.
Pharmacotherapies
Aminosalicylates
Sulfasalazine has been a major agent in the therapy of mild to moderate UC for over 50 years. In 1977 Mastan S.Kalsi et al determined that 5-aminosalicyclic acid (5-ASA and mesalazine) was the therapeutically active compound in sulfasalazine. Since then many 5-ASA compounds have been developed with the aim of maintaining efficacy but reducing the common side effects associated with the sulfapyridine moiety in sulfasalazine.[1]
- Mesalazine, also known as 5-aminosalicylic acid, 5-ASA, Asacol, Pentasa and Mesalamine.
- Sulfasalazine, also known as Azulfidine.
- Balsalazide, also known as Colazal.
- Olsalazine, also known as Dipentum.
Corticosteroids
Immunosuppressive drugs
- Mercaptopurine, also known as 6-Mercaptopurine, 6-MP and Purinethol.
- Azathioprine, also known as Imuran, Azasan or Azamun, which metabolises to 6-MP.
- Methotrexate, which inhibits folic acid
- Tacrolimus
Biological treatment
References
- ↑ S. Kane (2006). "Asacol - A Review Focusing on Ulcerative Colitis".