Hemochromatosis differential diagnosis: Difference between revisions
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Created page with "__NOTOC__ {{Hemochromatosis}} {{CMG}} ==Overview== ==Differentiating Hemochromatosis from other Diseases== ==References== {{reflist|2}} {{WH}} {{WS}}" |
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==Overview== | ==Overview== | ||
==Differentiating Hemochromatosis from other Diseases== | ==Differentiating Hemochromatosis from other Diseases== | ||
There exist other causes of excess iron accumulation, which have to be considered before Haemochromatosis is diagnosed. | |||
* '''[[African iron overload]]''', formerly known as Bantu siderosis, was first observed among people of African descent in Southern Africa. Originally, this was blamed on ungalvanised barrels used to store home-made beer, which led to increased oxidation and increased iron levels in the beer. Further investigation has shown that only some people drinking this sort of beer get an iron overload syndrome, and that a similar syndrome occurred in people of African descent who have had no contact with this kind of beer (''e.g.,'' African Americans). This led investigators to the discovery of a gene [[polymorphism (biology)|polymorphism]] in the gene for [[ferroportin]] which predisposes some people of African descent to iron overload.<ref name=Gordeuk_2003>{{cite journal |author=Gordeuk V, Caleffi A, Corradini E, Ferrara F, Jones R, Castro O, Onyekwere O, Kittles R, Pignatti E, Montosi G, Garuti C, Gangaidzo I, Gomo Z, Moyo V, Rouault T, MacPhail P, Pietrangelo A |title=Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene |journal=Blood Cells Mol Dis |volume=31 |issue=3 |pages=299-304 |year=2003 |pmid=14636642}}</ref> | |||
* '''[[Transfusion hemosiderosis]]''' is the accumulation of iron, mainly in the [[liver]], in patients who receive frequent [[blood transfusion]]s (such as those with [[thalassemia]]). | |||
* '''Dyserythropoeisis''', also known as [[myelodysplastic syndrome]] is a disorder in the production of red blood cells. This leads to increased iron recycling from the [[bone marrow]] and accumulation in the liver. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 12:42, 29 August 2012
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Differentiating Hemochromatosis from other Diseases
There exist other causes of excess iron accumulation, which have to be considered before Haemochromatosis is diagnosed.
- African iron overload, formerly known as Bantu siderosis, was first observed among people of African descent in Southern Africa. Originally, this was blamed on ungalvanised barrels used to store home-made beer, which led to increased oxidation and increased iron levels in the beer. Further investigation has shown that only some people drinking this sort of beer get an iron overload syndrome, and that a similar syndrome occurred in people of African descent who have had no contact with this kind of beer (e.g., African Americans). This led investigators to the discovery of a gene polymorphism in the gene for ferroportin which predisposes some people of African descent to iron overload.[1]
- Transfusion hemosiderosis is the accumulation of iron, mainly in the liver, in patients who receive frequent blood transfusions (such as those with thalassemia).
- Dyserythropoeisis, also known as myelodysplastic syndrome is a disorder in the production of red blood cells. This leads to increased iron recycling from the bone marrow and accumulation in the liver.
References
- ↑ Gordeuk V, Caleffi A, Corradini E, Ferrara F, Jones R, Castro O, Onyekwere O, Kittles R, Pignatti E, Montosi G, Garuti C, Gangaidzo I, Gomo Z, Moyo V, Rouault T, MacPhail P, Pietrangelo A (2003). "Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene". Blood Cells Mol Dis. 31 (3): 299–304. PMID 14636642.