Alcoholic hepatitis laboratory findings: Difference between revisions
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{{CMG}} '''Assosciate Editor(s)-In-Chief:''' [[User: Prashanthsaddala|Prashanth Saddala M.B.B.S]] | {{CMG}} '''Assosciate Editor(s)-In-Chief:''' [[User: Prashanthsaddala|Prashanth Saddala M.B.B.S]] | ||
==Overview== | ==Overview== | ||
== Laboratory | == Laboratory Findings== | ||
* AST:ALT (aspartate aminotransferase:alanine aminotransferase) classically 2:1. The ratio of aspartate aminotransferase to alanine aminotransferase is usually > 2.<ref name="pmid10201476">{{cite journal |author=Sorbi D, Boynton J, Lindor KD |title=The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease |journal=Am. J. Gastroenterol. |volume=94 |issue=4 |pages=1018-22 |year=1999 |pmid=10201476 |doi=}}</ref> | * AST:ALT (aspartate aminotransferase:alanine aminotransferase) classically 2:1. The ratio of aspartate aminotransferase to alanine aminotransferase is usually > 2.<ref name="pmid10201476">{{cite journal |author=Sorbi D, Boynton J, Lindor KD |title=The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in differentiating nonalcoholic steatohepatitis from alcoholic liver disease |journal=Am. J. Gastroenterol. |volume=94 |issue=4 |pages=1018-22 |year=1999 |pmid=10201476 |doi=}}</ref> | ||
*:* Reason for ratio not clear | *:* Reason for ratio not clear | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assosciate Editor(s)-In-Chief: Prashanth Saddala M.B.B.S
Overview
Laboratory Findings
- AST:ALT (aspartate aminotransferase:alanine aminotransferase) classically 2:1. The ratio of aspartate aminotransferase to alanine aminotransferase is usually > 2.[1]
- Reason for ratio not clear
- There may be disproportional damage to mitochondria releasing AST
- Alcoholics may have relative deficiencies of pyridoxal-6-phosphatase
- > 300-500 worry about other hepatotoxins
- Reason for ratio not clear
- Alkaline phosphatase, gamma-glutamyltranspeptidase (GGT) and bilirubin often rise proportionally, and may persist for weeks after transaminases normalize.
- A leucocytosis is commonly seen. If other causes can be excluded, the degree of rise correlates with severity of hepatic injury.