Adrenoleukodystrophy causes: Difference between revisions
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{{Adrenoleukodystrophy}} | {{Adrenoleukodystrophy}} | ||
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==Overview== | ==Overview== | ||
==Causes== | ==Causes== | ||
[[Adrenoleukodystrophy]] is passed down from parents to their children as an [[X-linked]] [[genetic trait]]. It therefore affects mostly [[males]], although some [[women]] who are [[Genetic carrier|carriers]] can have milder forms of the [[disease]]. It affects approximately 1 in 20,000 people from all races. | [[Adrenoleukodystrophy]] is passed down from parents to their children as an [[X-linked]] [[genetic trait]]. It therefore affects mostly [[males]], although some [[women]] who are [[Genetic carrier|carriers]] can have milder forms of the [[disease]]. It affects approximately 1 in 20,000 people from all races. | ||
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*Adrenomyelopathy -- occurs in men in their 20s or later in life | *Adrenomyelopathy -- occurs in men in their 20s or later in life | ||
*Impaired [[adrenal gland]] function (called [[Addison disease]] or Addison-like [[phenotype]]) -- [[adrenal gland]] does not produce enough [[steroid hormones]] | *Impaired [[adrenal gland]] function (called [[Addison disease]] or Addison-like [[phenotype]]) -- [[adrenal gland]] does not produce enough [[steroid hormones]] | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Endocrinology]] | |||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 18:32, 22 July 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Causes
Adrenoleukodystrophy is passed down from parents to their children as an X-linked genetic trait. It therefore affects mostly males, although some women who are carriers can have milder forms of the disease. It affects approximately 1 in 20,000 people from all races.
The condition results in the buildup of very-long-chain fatty acids in the nervous system, adrenal gland, and testes, which disrupts normal activity. There are three major categories of disease:
- Childhood cerebral form -- appears in mid-childhood (at ages 4 - 8)
- Adrenomyelopathy -- occurs in men in their 20s or later in life
- Impaired adrenal gland function (called Addison disease or Addison-like phenotype) -- adrenal gland does not produce enough steroid hormones