API5: Difference between revisions

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Revision as of 18:07, 29 August 2017

The human gene API5 encodes the protein Apoptosis inhibitor 5.^[1]^[2]

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs.

Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.

References

↑ Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res. 57 (18): 4063–9. PMID 9307294.
↑ "Entrez Gene: API5 apoptosis inhibitor 5".

External links

Human API5 genome location and API5 gene details page in the UCSC Genome Browser.

Gianfrancesco F, Esposito T, Ciccodicola A, et al. (1999). "Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene". Cytogenet. Cell Genet. 84 (3–4): 164–6. doi:10.1159/000015247. PMID 10393420.
Kim JW, Cho HS, Kim JH, et al. (2000). "AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis". Lab. Invest. 80 (4): 587–94. doi:10.1038/labinvest.3780008. PMID 10780674.
Van den Berghe L, Laurell H, Huez I, et al. (2001). "FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2". Mol. Endocrinol. 14 (11): 1709–24. doi:10.1210/me.14.11.1709. PMID 11075807.
Sutherland HG, Mumford GK, Newton K, et al. (2001). "Large-scale identification of mammalian proteins localized to nuclear sub-compartments". Hum. Mol. Genet. 10 (18): 1995–2011. doi:10.1093/hmg/10.18.1995. PMID 11555636.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Li Z, Hu CY, Mo BQ, et al. (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng. 22 (4): 380–4. PMID 12703993.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Morris EJ, Michaud WA, Ji JY, et al. (2006). "Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo". PLoS Genet. 2 (11): e196. doi:10.1371/journal.pgen.0020196. PMC 1636698. PMID 17112319. open access publication – free to read

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid9307294-1] Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (Oct 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Res. 57 (18): 4063–9. PMID 9307294.

[entrez-2] "Entrez Gene: API5 apoptosis inhibitor 5".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal |vauthors=Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Res | volume = 57 | issue = 18 | pages = 4063–9 |date=Oct 1997 | pmid = 9307294 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
+This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs.
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+Diseases associated with API5 include colon [[adenocarcinoma]], and [[cervical cancer]].
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Apoptosis inhibitor 5
- | HGNCid = 594
- | Symbol = API5
- | AltSymbols =; AAC-11; AAC11; API5L1
- | OMIM = 609774
- | ECnumber =
- | Homologene = 4809
- | MGIid = 1888993
- | Function = {{GNF_GO|id=GO:0017134 |text = fibroblast growth factor binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
- | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8539
-    | Hs_Ensembl = ENSG00000166181
-    | Hs_RefseqProtein = NP_006586
-    | Hs_RefseqmRNA = NM_006595
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 11
-    | Hs_GenLoc_start = 43290109
-    | Hs_GenLoc_end = 43322655
-    | Hs_Uniprot = Q9BZZ5
-    | Mm_EntrezGene = 11800
-    | Mm_Ensembl = ENSMUSG00000027193
-    | Mm_RefseqmRNA = NM_007466
-    | Mm_RefseqProtein = NP_031492
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 2
-    | Mm_GenLoc_start = 94212571
-    | Mm_GenLoc_end = 94238912
-    | Mm_Uniprot = Q3U517
-  }}
-}}
-'''Apoptosis inhibitor 5''', also known as '''API5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
 | summary_text =
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|API5}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Tewari M, Yu M, Ross B, ''et al.'' |title=AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal. |journal=Cancer Res. |volume=57 |issue= 18 |pages= 4063-9 |year= 1997 |pmid= 9307294 |doi=  }}
+*{{cite journal |vauthors=Gianfrancesco F, Esposito T, Ciccodicola A |title=Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 164–6 |year= 1999 |pmid= 10393420 |doi=10.1159/000015247 |display-authors=etal}}
-*{{cite journal  | author=Gianfrancesco F, Esposito T, Ciccodicola A, ''et al.'' |title=Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 164-6 |year= 1999 |pmid= 10393420 |doi=  }}
+*{{cite journal |vauthors=Kim JW, Cho HS, Kim JH |title=AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. |journal=Lab. Invest. |volume=80 |issue= 4 |pages= 587–94 |year= 2000 |pmid= 10780674 |doi=10.1038/labinvest.3780008 |display-authors=etal}}
-*{{cite journal  | author=Kim JW, Cho HS, Kim JH, ''et al.'' |title=AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. |journal=Lab. Invest. |volume=80 |issue= 4 |pages= 587-94 |year= 2000 |pmid= 10780674 |doi=  }}
+*{{cite journal |vauthors=Van den Berghe L, Laurell H, Huez I |title=FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. |journal=Mol. Endocrinol. |volume=14 |issue= 11 |pages= 1709–24 |year= 2001 |pmid= 11075807 |doi=10.1210/me.14.11.1709 |display-authors=etal}}
-*{{cite journal  | author=Van den Berghe L, Laurell H, Huez I, ''et al.'' |title=FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. |journal=Mol. Endocrinol. |volume=14 |issue= 11 |pages= 1709-24 |year= 2001 |pmid= 11075807 |doi=  }}
+*{{cite journal |vauthors=Sutherland HG, Mumford GK, Newton K |title=Large-scale identification of mammalian proteins localized to nuclear sub-compartments. |journal=Hum. Mol. Genet. |volume=10 |issue= 18 |pages= 1995–2011 |year= 2001 |pmid= 11555636 |doi=10.1093/hmg/10.18.1995 |display-authors=etal}}
-*{{cite journal  | author=Sutherland HG, Mumford GK, Newton K, ''et al.'' |title=Large-scale identification of mammalian proteins localized to nuclear sub-compartments. |journal=Hum. Mol. Genet. |volume=10 |issue= 18 |pages= 1995-2011 |year= 2001 |pmid= 11555636 |doi=  }}
+*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal |vauthors=Li Z, Hu CY, Mo BQ |title=[Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380–4 |year= 2003 |pmid= 12703993 |doi= |display-authors=etal}}
-*{{cite journal  | author=Li Z, Hu CY, Mo BQ, ''et al.'' |title=[Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380-4 |year= 2003 |pmid= 12703993 |doi=  }}
+*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
-*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
+*{{cite journal |vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
-*{{cite journal  | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339-46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
+*{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
+*{{cite journal |vauthors=Morris EJ, Michaud WA, Ji JY |title=Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. |journal=PLoS Genet. |volume=2 |issue= 11 |pages= e196 |year= 2006 |pmid= 17112319 |doi= 10.1371/journal.pgen.0020196 | pmc=1636698 |display-authors=etal}} {{open access}}
-*{{cite journal  | author=Morris EJ, Michaud WA, Ji JY, ''et al.'' |title=Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. |journal=PLoS Genet. |volume=2 |issue= 11 |pages= e196 |year= 2006 |pmid= 17112319 |doi= 10.1371/journal.pgen.0020196 }}
 }}
 {{refend}}
-{{protein-stub}}
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+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
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+{{gene-11-stub}}

API5: Difference between revisions

Revision as of 18:07, 29 August 2017

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