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{{Infobox_gene}}
{{PBB_Controls
{{Infobox protein family
| update_page = yes
| Symbol = ApoM
| require_manual_inspection = no
| Name = ApoM
| update_protein_box = yes
| image =
| update_summary = yes
| width =
| update_citations = yes
| caption = crystal structure of human apom in complex with glycerol 1-myristic acid
| Pfam = PF11032
| Pfam_clan = CL0116
| InterPro = IPR022734
| SMART =
| PROSITE =
| MEROPS =
| SCOP =
| TCDB =  
| OPM family =  
| OPM protein =  
| CAZy =  
| CDD =  
}}
}}
 
'''Apolipoprotein M''' is a [[protein]] that in humans is encoded by the ''APOM'' [[gene]].<ref name="pmid10531326">{{cite journal |vauthors=Xu N, Dahlback B | title = A novel human apolipoprotein (apoM) | journal = J Biol Chem | volume = 274 | issue = 44 | pages = 31286–90 |date=Dec 1999 | pmid = 10531326 | pmc =  | doi =10.1074/jbc.274.44.31286 }}</ref><ref name="pmid11418126">{{cite journal |vauthors=Duan J, Dahlback B, Villoutreix BO | title = Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis | journal = FEBS Lett | volume = 499 | issue = 1–2 | pages = 127–32 |date=Jun 2001 | pmid = 11418126 | pmc =  | doi =10.1016/S0014-5793(01)02544-3 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: APOM apolipoprotein M| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55937| accessdate = }}</ref>
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Apolipoprotein M
| HGNCid = 13916
| Symbol = APOM
| AltSymbols =; G3a; HSPC336; MGC22400; NG20
| OMIM = 606907
| ECnumber =
  | Homologene = 10308
| MGIid = 1930124
| GeneAtlas_image1 = PBB_GE_APOM_214910_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_APOM_205682_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0005319 |text = lipid transporter activity}}  
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006643 |text = membrane lipid metabolic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55937
    | Hs_Ensembl = ENSG00000204444
    | Hs_RefseqProtein = NP_061974
    | Hs_RefseqmRNA = NM_019101
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 31728172
    | Hs_GenLoc_end = 31733966
    | Hs_Uniprot = O95445
    | Mm_EntrezGene = 55938
    | Mm_Ensembl = ENSMUSG00000024391
    | Mm_RefseqmRNA = NM_018816
    | Mm_RefseqProtein = NP_061286
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 34737057
    | Mm_GenLoc_end = 34739852
    | Mm_Uniprot = Q8VC79
  }}
}}
'''Apolipoprotein M''', also known as '''APOM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: APOM apolipoprotein M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55937| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized.<ref name="entrez">{{cite web | title = Entrez Gene: APOM apolipoprotein M| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55937| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is an [[apolipoprotein]] and member of the [[lipocalin]] [[protein family]]. It is found associated with [[high density lipoprotein]]s and to a lesser extent with [[low density lipoprotein]]s and [[triglyceride]]-rich [[lipoprotein]]s. The encoded protein is [[secrete]]d through the [[plasma membrane]] but remains membrane-bound, where it is involved in [[lipid transport]]. Two [[Transcription (genetics)|transcript]] variants encoding two different [[isoform]]s have been found for this gene, but only one of them has been fully characterized.<ref name="entrez" /> The average molecular weight is 21253 Da, and the monoisotopic molecular weight is 21239 Da.
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Albertella MR, Jones H, Thomson W, ''et al.'' |title=Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B). |journal=Genomics |volume=36 |issue= 2 |pages= 240-51 |year= 1997 |pmid= 8812450 |doi= 10.1006/geno.1996.0459 }}
*{{cite journal  |vauthors=Albertella MR, Jones H, Thomson W |title=Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B) |journal=Genomics |volume=36 |issue= 2 |pages= 240–51 |year= 1997 |pmid= 8812450 |doi= 10.1006/geno.1996.0459 |display-authors=etal}}
*{{cite journal  | author=Xu N, Dahlbäck B |title=A novel human apolipoprotein (apoM). |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31286-90 |year= 1999 |pmid= 10531326 |doi= }}
*{{cite journal  |vauthors=Xu N, Zhang XY, Dong X |title=Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 4 |pages= 944–50 |year= 2002 |pmid= 11944906 |doi= 10.1006/bbrc.2002.6755 |display-authors=etal}}
*{{cite journal  | author=Duan J, Dahlbäck B, Villoutreix BO |title=Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis. |journal=FEBS Lett. |volume=499 |issue= 1-2 |pages= 127-32 |year= 2001 |pmid= 11418126 |doi= }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Xu N, Zhang XY, Dong X, ''et al.'' |title=Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 4 |pages= 944-50 |year= 2002 |pmid= 11944906 |doi= 10.1006/bbrc.2002.6755 }}
*{{cite journal  |vauthors=Zhang XY, Dong X, Zheng L |title=Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization |journal=Acta Histochem. |volume=105 |issue= 1 |pages= 67–72 |year= 2003 |pmid= 12666989 |doi=10.1078/0065-1281-00687  |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal  | author=Zhang XY, Dong X, Zheng L, ''et al.'' |title=Specific tissue expression and cellular localization of human apolipoprotein M as determined by in situ hybridization. |journal=Acta Histochem. |volume=105 |issue= 1 |pages= 67-72 |year= 2003 |pmid= 12666989 |doi= }}
*{{cite journal  |vauthors=Richter S, Shih DQ, Pearson ER |title=Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels |journal=Diabetes |volume=52 |issue= 12 |pages= 2989–95 |year= 2004 |pmid= 14633861 |doi=10.2337/diabetes.52.12.2989  |display-authors=etal}}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  |vauthors=Xie T, Rowen L, Aguado B |title=Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621–36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803  | pmc=403804 |display-authors=etal}}
*{{cite journal  | author=Richter S, Shih DQ, Pearson ER, ''et al.'' |title=Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is associated with reduced serum apolipoprotein M levels. |journal=Diabetes |volume=52 |issue= 12 |pages= 2989-95 |year= 2004 |pmid= 14633861 |doi= }}
*{{cite journal  |vauthors=Zhang XY, Jiao GQ, Hurtig M |title=Expression pattern of apolipoprotein M during mouse and human embryogenesis |journal=Acta Histochem. |volume=106 |issue= 2 |pages= 123–8 |year= 2005 |pmid= 15147633 |doi= 10.1016/j.acthis.2003.11.004 |display-authors=etal}}
*{{cite journal  | author=Xie T, Rowen L, Aguado B, ''et al.'' |title=Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. |journal=Genome Res. |volume=13 |issue= 12 |pages= 2621-36 |year= 2004 |pmid= 14656967 |doi= 10.1101/gr.1736803 }}
*{{cite journal  |vauthors=Kabbara A, Payet N, Cottel D |title=Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population |journal=Neurosci. Lett. |volume=363 |issue= 2 |pages= 139–43 |year= 2004 |pmid= 15172102 |doi= 10.1016/j.neulet.2004.03.066 |display-authors=etal}}
*{{cite journal  | author=Zhang XY, Jiao GQ, Hurtig M, ''et al.'' |title=Expression pattern of apolipoprotein M during mouse and human embryogenesis. |journal=Acta Histochem. |volume=106 |issue= 2 |pages= 123-8 |year= 2005 |pmid= 15147633 |doi= 10.1016/j.acthis.2003.11.004 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Kabbara A, Payet N, Cottel D, ''et al.'' |title=Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. |journal=Neurosci. Lett. |volume=363 |issue= 2 |pages= 139-43 |year= 2004 |pmid= 15172102 |doi= 10.1016/j.neulet.2004.03.066 }}
*{{cite journal  |vauthors=Xu N, Nilsson-Ehle P, Ahrén B |title=Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects |journal=J. Nutr. Biochem. |volume=15 |issue= 10 |pages= 579–82 |year= 2005 |pmid= 15542348 |doi= 10.1016/j.jnutbio.2004.03.001 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Luo G, Hurtig M, Zhang X |title=Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells |journal=Biochim. Biophys. Acta |volume=1734 |issue= 2 |pages= 198–202 |year= 2005 |pmid= 15904876 |doi= 10.1016/j.bbalip.2005.02.005 |display-authors=etal}}
*{{cite journal  | author=Xu N, Nilsson-Ehle P, Ahrén B |title=Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects. |journal=J. Nutr. Biochem. |volume=15 |issue= 10 |pages= 579-82 |year= 2005 |pmid= 15542348 |doi= 10.1016/j.jnutbio.2004.03.001 }}
*{{cite journal  |vauthors=Liu T, Qian WJ, Gritsenko MA |title=Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065  | pmc=1850943 |display-authors=etal}}
*{{cite journal  | author=Luo G, Hurtig M, Zhang X, ''et al.'' |title=Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells. |journal=Biochim. Biophys. Acta |volume=1734 |issue= 2 |pages= 198-202 |year= 2005 |pmid= 15904876 |doi= 10.1016/j.bbalip.2005.02.005 }}
*{{cite journal  |vauthors=Niu N, Zhu X, Liu Y |title=Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han Chinese |journal=Diabetes Metab. Res. Rev. |volume=23 |issue= 1 |pages= 21–5 |year= 2007 |pmid= 16572495 |doi= 10.1002/dmrr.641 |display-authors=etal}}
*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070-80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065 }}
*{{cite journal  |vauthors=Christoffersen C, Nielsen LB, Axler O |title=Isolation and characterization of human apolipoprotein M-containing lipoproteins |journal=J. Lipid Res. |volume=47 |issue= 8 |pages= 1833–43 |year= 2006 |pmid= 16682745 |doi= 10.1194/jlr.M600055-JLR200 |display-authors=etal}}
*{{cite journal  | author=Niu N, Zhu X, Liu Y, ''et al.'' |title=Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han Chinese. |journal=Diabetes Metab. Res. Rev. |volume=23 |issue= 1 |pages= 21-5 |year= 2007 |pmid= 16572495 |doi= 10.1002/dmrr.641 }}
*{{cite journal  |vauthors=Karlsson H, Lindqvist H, Tagesson C, Lindahl M |title=Characterization of apolipoprotein M isoforms in low-density lipoprotein |journal=J. Proteome Res. |volume=5 |issue= 10 |pages= 2685–90 |year= 2006 |pmid= 17022639 |doi= 10.1021/pr060180x }}
*{{cite journal  | author=Christoffersen C, Nielsen LB, Axler O, ''et al.'' |title=Isolation and characterization of human apolipoprotein M-containing lipoproteins. |journal=J. Lipid Res. |volume=47 |issue= 8 |pages= 1833-43 |year= 2006 |pmid= 16682745 |doi= 10.1194/jlr.M600055-JLR200 }}
*{{cite journal  |vauthors=Xu X, Ye Q, Xu N |title=Effects of ischemia-reperfusion injury on apolipoprotein M expression in the liver |journal=Transplant. Proc. |volume=38 |issue= 9 |pages= 2769–73 |year= 2007 |pmid= 17112825 |doi= 10.1016/j.transproceed.2006.08.133 |display-authors=etal}}
*{{cite journal  | author=Karlsson H, Lindqvist H, Tagesson C, Lindahl M |title=Characterization of apolipoprotein M isoforms in low-density lipoprotein. |journal=J. Proteome Res. |volume=5 |issue= 10 |pages= 2685-90 |year= 2006 |pmid= 17022639 |doi= 10.1021/pr060180x }}
*{{cite journal  |vauthors=Ahnström J, Faber K, Axler O, Dahlbäck B |title=Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M |journal=J. Lipid Res. |volume=48 |issue= 8 |pages= 1754–62 |year= 2007 |pmid= 17525477 |doi= 10.1194/jlr.M700103-JLR200 }}
*{{cite journal  | author=Xu X, Ye Q, Xu N, ''et al.'' |title=Effects of ischemia-reperfusion injury on apolipoprotein M expression in the liver. |journal=Transplant. Proc. |volume=38 |issue= 9 |pages= 2769-73 |year= 2007 |pmid= 17112825 |doi= 10.1016/j.transproceed.2006.08.133 }}
*{{cite journal  | author=Ahnström J, Faber K, Axler O, Dahlbäck B |title=Hydrophobic ligand binding properties of the human lipocalin apolipoprotein M. |journal=J. Lipid Res. |volume=48 |issue= 8 |pages= 1754-62 |year= 2007 |pmid= 17525477 |doi= 10.1194/jlr.M700103-JLR200 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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{{WikiDoc Sources}}
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== External links ==
* [https://www.mabtech.com/knowledge-center/applied-research/apolipoproteins Applied Research on apoM]
* {{UCSC gene info|APOM}}
 
{{gene-6-stub}}

Latest revision as of 18:09, 29 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
ApoM
Identifiers
SymbolApoM
PfamPF11032
Pfam clanCL0116
InterProIPR022734

Apolipoprotein M is a protein that in humans is encoded by the APOM gene.[1][2][3]

The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Two transcript variants encoding two different isoforms have been found for this gene, but only one of them has been fully characterized.[3] The average molecular weight is 21253 Da, and the monoisotopic molecular weight is 21239 Da.

References

  1. ↑ Xu N, Dahlback B (Dec 1999). "A novel human apolipoprotein (apoM)". J Biol Chem. 274 (44): 31286–90. doi:10.1074/jbc.274.44.31286. PMID 10531326.
  2. ↑ Duan J, Dahlback B, Villoutreix BO (Jun 2001). "Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis". FEBS Lett. 499 (1–2): 127–32. doi:10.1016/S0014-5793(01)02544-3. PMID 11418126.
  3. ↑ 3.0 3.1 "Entrez Gene: APOM apolipoprotein M".

Further reading


External links

Retrieved from "https://www.wikidoc.org/index.php?title=APOM&oldid=1421371"