ATP6AP2: Difference between revisions
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{{ | The '''renin receptor''' also known as '''ATPase H(+)-transporting lysosomal accessory protein 2''', or the '''prorenin receptor''', is a [[protein]] that in humans is encoded by the ''ATP6AP2'' [[gene]].<ref name="pmid9556572">{{cite journal | vauthors = Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H | title = Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules | journal = J Biol Chem | volume = 273 | issue = 18 | pages = 10939–47 |date=Jun 1998 | pmid = 9556572 | pmc = | doi =10.1074/jbc.273.18.10939 }}</ref><ref name="pmid11590366">{{cite journal | vauthors = Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB | title = Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4) | journal = Mol Vis | volume = 7 | issue = | pages = 234–9 |date=Oct 2001 | pmid = 11590366 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10159| accessdate = }}</ref> | ||
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| | == Function == | ||
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The renin receptor binds [[renin]] and prorenin. Binding of renin to this receptor induces the conversion of [[Angiotensin#Angiotensinogen|angiotensinogen]] to [[Angiotensin#Angiotensin I|angiotensin I]].<ref name="pmid12045255">{{cite journal | vauthors = Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD | title = Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin | journal = J. Clin. Invest. | volume = 109 | issue = 11 | pages = 1417–27 |date=June 2002 | pmid = 12045255 | pmc = 150992 | doi = 10.1172/JCI14276 | url = | issn = }}</ref> | |||
This protein is associated with adenosine triphosphatases ([[ATPase]]s). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.<ref name="entrez"/> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Kaneshiro Y, Ichihara A, Sakoda M |title=Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats. |journal=J. Am. Soc. Nephrol. |volume=18 |issue= 6 |pages= 1789–95 |year= 2007 |pmid= 17494887 |doi= 10.1681/ASN.2006091062 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Schefe JH, Menk M, Reinemund J |title=A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. |journal=Circ. Res. |volume=99 |issue= 12 |pages= 1355–66 |year= 2007 |pmid= 17082479 |doi= 10.1161/01.RES.0000251700.00994.0d |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Kaneshiro Y, Ichihara A, Takemitsu T |title=Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats. |journal=Kidney Int. |volume=70 |issue= 4 |pages= 641–6 |year= 2006 |pmid= 16807542 |doi= 10.1038/sj.ki.5001627 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Burcklé CA, Jan Danser AH, Müller DN |title=Elevated blood pressure and heart rate in human renin receptor transgenic rats. |journal=Hypertension |volume=47 |issue= 3 |pages= 552–6 |year= 2006 |pmid= 16401765 |doi= 10.1161/01.HYP.0000199912.47657.04 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Huang Y, Wongamorntham S, Kasting J |title=Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. |journal=Kidney Int. |volume=69 |issue= 1 |pages= 105–13 |year= 2006 |pmid= 16374430 |doi= 10.1038/sj.ki.5000011 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ramser J, Abidi FE, Burckle CA |title=A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 1019–27 |year= 2005 |pmid= 15746149 |doi= 10.1093/hmg/ddi094 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | vauthors=Hedera P, Alvarado D, Beydoun A, Fink JK |title=Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4. |journal=Ann. Neurol. |volume=51 |issue= 1 |pages= 45–50 |year= 2002 |pmid= 11782983 |doi=10.1002/ana.10051 }} | |||
*{{cite journal | | *{{cite journal | vauthors=Hu RM, Han ZG, Song HD |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 |display-authors=etal}} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{ | ==External links== | ||
{{ | * {{UCSC genome browser|ATP6AP2}} | ||
* {{UCSC gene details|ATP6AP2}} | |||
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[[Category:Transmembrane receptors]] | |||
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The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[1][2][3]
Function
The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.[4]
This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[3]
References
- ↑ Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, Schagger H (Jun 1998). "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem. 273 (18): 10939–47. doi:10.1074/jbc.273.18.10939. PMID 9556572.
- ↑ Demirci FY, White NJ, Rigatti BW, Lewis KF, Gorin MB (Oct 2001). "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis. 7: 234–9. PMID 11590366.
- ↑ 3.0 3.1 "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2".
- ↑ Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD (June 2002). "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. doi:10.1172/JCI14276. PMC 150992. PMID 12045255.
Further reading
- Kaneshiro Y, Ichihara A, Sakoda M, et al. (2007). "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats". J. Am. Soc. Nephrol. 18 (6): 1789–95. doi:10.1681/ASN.2006091062. PMID 17494887.
- Schefe JH, Menk M, Reinemund J, et al. (2007). "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein". Circ. Res. 99 (12): 1355–66. doi:10.1161/01.RES.0000251700.00994.0d. PMID 17082479.
- Kaneshiro Y, Ichihara A, Takemitsu T, et al. (2006). "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats". Kidney Int. 70 (4): 641–6. doi:10.1038/sj.ki.5001627. PMID 16807542.
- Burcklé CA, Jan Danser AH, Müller DN, et al. (2006). "Elevated blood pressure and heart rate in human renin receptor transgenic rats". Hypertension. 47 (3): 552–6. doi:10.1161/01.HYP.0000199912.47657.04. PMID 16401765.
- Huang Y, Wongamorntham S, Kasting J, et al. (2006). "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms". Kidney Int. 69 (1): 105–13. doi:10.1038/sj.ki.5000011. PMID 16374430.
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Ramser J, Abidi FE, Burckle CA, et al. (2005). "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor". Hum. Mol. Genet. 14 (8): 1019–27. doi:10.1093/hmg/ddi094. PMID 15746149.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hedera P, Alvarado D, Beydoun A, Fink JK (2002). "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4". Ann. Neurol. 51 (1): 45–50. doi:10.1002/ana.10051. PMID 11782983.
- Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
External links
- ATP6AP2 human gene location in the UCSC Genome Browser.
- ATP6AP2 human gene details in the UCSC Genome Browser.
This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it. |