BCAR3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Breast cancer anti-estrogen resistance protein 3''' is a [[protein]] that in humans is encoded by the ''BCAR3'' [[gene]].<ref name="pmid9582273">{{cite journal | vauthors = van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC | title = Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells | journal = EMBO J | volume = 17 | issue = 10 | pages = 2799–808 |date=Jul 1998 | pmid = 9582273 | pmc = 1170620 | doi = 10.1093/emboj/17.10.2799 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8412| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Breast cancer anti-estrogen resistance 3
| HGNCid = 973
| Symbol = BCAR3
| AltSymbols =; NSP2; KIAA0554; SH2D3B
| OMIM = 604704
| ECnumber = 
| Homologene = 31181
| MGIid = 1352501
| GeneAtlas_image1 = PBB_GE_BCAR3_204032_at_tn.png
| Function = {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0042493 |text = response to drug}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8412
    | Hs_Ensembl = ENSG00000137936
    | Hs_RefseqProtein = NP_003558
    | Hs_RefseqmRNA = NM_003567
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 93799935
    | Hs_GenLoc_end = 94085294
    | Hs_Uniprot = O75815
    | Mm_EntrezGene = 29815
    | Mm_Ensembl = ENSMUSG00000028121
    | Mm_RefseqmRNA = NM_013867
    | Mm_RefseqProtein = NP_038895
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 122411820
    | Mm_GenLoc_end = 122522202
    | Mm_Uniprot = Q9QZK2
  }}
}}
'''Breast cancer anti-estrogen resistance 3''', also known as '''BCAR3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8412| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Breast tumors are initially dependent on [[estrogen]]s for growth and progression and can be inhibited by anti-estrogens such as [[tamoxifen]]. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 ([[SH2 domain|SH2]]) domain, a hallmark of cellular [[tyrosine kinase]] signaling molecules, and is partly homologous to the cell division cycle protein [[CDC48]].<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.<ref name="entrez">{{cite web | title = Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8412| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|BCAR3}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Dorssers LC, van Agthoven T |title=Genetic mechanisms of estrogen-independence in breast cancer. |journal=Pathol. Res. Pract. |volume=192 |issue= 7 |pages= 743–51 |year= 1997 |pmid= 8880875 |doi=  10.1016/S0344-0338(96)80096-3}}
| citations =
*{{cite journal  | author=Johnston SR |title=Acquired tamoxifen resistance in human breast cancer--potential mechanisms and clinical implications. |journal=Anticancer Drugs |volume=8 |issue= 10 |pages= 911–30 |year= 1998 |pmid= 9436634 |doi=10.1097/00001813-199711000-00002 }}
*{{cite journal  | author=Dorssers LC, van Agthoven T |title=Genetic mechanisms of estrogen-independence in breast cancer. |journal=Pathol. Res. Pract. |volume=192 |issue= 7 |pages= 743-51 |year= 1997 |pmid= 8880875 |doi=  }}
*{{cite journal  | vauthors=Lu Y, Brush J, Stewart TA |title=NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10047–52 |year= 1999 |pmid= 10187783 |doi=10.1074/jbc.274.15.10047  }}
*{{cite journal  | author=Johnston SR |title=Acquired tamoxifen resistance in human breast cancer--potential mechanisms and clinical implications. |journal=Anticancer Drugs |volume=8 |issue= 10 |pages= 911-30 |year= 1998 |pmid= 9436634 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=van Agthoven T, van Agthoven TL, Dekker A, ''et al.'' |title=Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. |journal=EMBO J. |volume=17 |issue= 10 |pages= 2799-808 |year= 1998 |pmid= 9582273 |doi= 10.1093/emboj/17.10.2799 }}
*{{cite journal  | vauthors=Cai D, Felekkis KN, Near RI |title=The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. |journal=J. Immunol. |volume=170 |issue= 2 |pages= 969–78 |year= 2003 |pmid= 12517963 |doi= 10.4049/jimmunol.170.2.969|display-authors=etal}}
*{{cite journal  | author=Lu Y, Brush J, Stewart TA |title=NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10047-52 |year= 1999 |pmid= 10187783 |doi= }}
*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Cai D, Felekkis KN, Near RI, ''et al.'' |title=The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. |journal=J. Immunol. |volume=170 |issue= 2 |pages= 969-78 |year= 2003 |pmid= 12517963 |doi= }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | vauthors=Dorssers LC, van Agthoven T, Brinkman A |title=Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway. |journal=Breast Cancer Res. |volume=7 |issue= 1 |pages= R82–92 |year= 2006 |pmid= 15642172 |doi= 10.1186/bcr954  | pmc=1064102 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Felekkis KN, Narsimhan RP, Near R |title=AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. |journal=Mol. Cancer Res. |volume=3 |issue= 1 |pages= 32–41 |year= 2005 |pmid= 15671247 |doi= |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gregory SG, Barlow KF, McLay KE |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |display-authors=etal}}
*{{cite journal  | author=Dorssers LC, van Agthoven T, Brinkman A, ''et al.'' |title=Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway. |journal=Breast Cancer Res. |volume=7 |issue= 1 |pages= R82-92 |year= 2006 |pmid= 15642172 |doi= 10.1186/bcr954 }}
*{{cite journal  | vauthors=Beausoleil SA, Villén J, Gerber SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |display-authors=etal}}
*{{cite journal  | author=Felekkis KN, Narsimhan RP, Near R, ''et al.'' |title=AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. |journal=Mol. Cancer Res. |volume=3 |issue= 1 |pages= 32-41 |year= 2005 |pmid= 15671247 |doi= }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | vauthors=Vervoort VS, Roselli S, Oshima RG, Pasquale EB |title=Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. |journal=Gene |volume=391 |issue= 1-2 |pages= 161–70 |year= 2007 |pmid= 17270363 |doi= 10.1016/j.gene.2006.12.016  | pmc=1876674 }}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134  | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Near RI, Zhang Y, Makkinje A |title=AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. |journal=J. Cell. Physiol. |volume=212 |issue= 3 |pages= 655–65 |year= 2007 |pmid= 17427198 |doi= 10.1002/jcp.21059  | pmc=2640322 |display-authors=etal}}
*{{cite journal  | author=Vervoort VS, Roselli S, Oshima RG, Pasquale EB |title=Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. |journal=Gene |volume=391 |issue= 1-2 |pages= 161-70 |year= 2007 |pmid= 17270363 |doi= 10.1016/j.gene.2006.12.016 }}
*{{cite journal  | vauthors=Schrecengost RS, Riggins RB, Thomas KS |title=Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. |journal=Cancer Res. |volume=67 |issue= 13 |pages= 6174–82 |year= 2007 |pmid= 17616674 |doi= 10.1158/0008-5472.CAN-06-3455 |display-authors=etal}}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Near RI, Zhang Y, Makkinje A, ''et al.'' |title=AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. |journal=J. Cell. Physiol. |volume=212 |issue= 3 |pages= 655-65 |year= 2007 |pmid= 17427198 |doi= 10.1002/jcp.21059 }}
*{{cite journal  | author=Schrecengost RS, Riggins RB, Thomas KS, ''et al.'' |title=Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. |journal=Cancer Res. |volume=67 |issue= 13 |pages= 6174-82 |year= 2007 |pmid= 17616674 |doi= 10.1158/0008-5472.CAN-06-3455 }}
}}
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{{refend}}


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Revision as of 02:31, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.[1][2]

Function

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48.[2]

References

  1. ↑ van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC (Jul 1998). "Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells". EMBO J. 17 (10): 2799–808. doi:10.1093/emboj/17.10.2799. PMC 1170620. PMID 9582273.
  2. ↑ 2.0 2.1 "Entrez Gene: BCAR3 breast cancer anti-estrogen resistance 3".

External links

Further reading


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