BICD2: Difference between revisions

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{{Infobox_gene}}
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'''Protein bicaudal D homolog 2''' is a [[protein]] that in humans is encoded by the ''BICD2'' [[gene]].<ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 3 | pages = 169–76 |date=Dec 1998 | pmid = 9734811 | pmc =  | doi =10.1093/dnares/5.3.169 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BICD2 bicaudal D homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23299| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Bicaudal D homolog 2 (Drosophila)
| HGNCid = 17208
| Symbol = BICD2
| AltSymbols =; KIAA0699; bA526D8.1
| OMIM = 609797
| ECnumber =
| Homologene = 9070
  | MGIid = 1924145
| GeneAtlas_image1 = PBB_GE_BICD2_209203_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BICD2_212702_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_BICD2_213154_s_at_tn.png
| Function =
  | Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}  
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23299
    | Hs_Ensembl = ENSG00000185963
    | Hs_RefseqProtein = NP_001003800
    | Hs_RefseqmRNA = NM_001003800
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 94513466
    | Hs_GenLoc_end = 94566915
    | Hs_Uniprot = Q8TD16
    | Mm_EntrezGene = 76895
    | Mm_Ensembl = ENSMUSG00000037933
    | Mm_RefseqmRNA = NM_001039179
    | Mm_RefseqProtein = NP_001034268
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 49353486
    | Mm_GenLoc_end = 49398962
    | Mm_Uniprot = Q3TBD4
  }}
}}
'''Bicaudal D homolog 2 (Drosophila)''', also known as '''BICD2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BICD2 bicaudal D homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23299| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.<ref name="entrez">{{cite web | title = Entrez Gene: BICD2 bicaudal D homolog 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23299| accessdate = }}</ref>
| summary_text = This gene is one of two human [[homolog]]s of [[Drosophila]] bicaudal-D and a member of the [[Drosophila embryogenesis|Bicoid]] family. It has been implicated in [[dynein]]-mediated, minus end-directed [[motility]] along [[microtubule]]s. It has also been reported to be a [[phosphorylation]] target of NIMA related [[kinase]] 8. Two alternative splice variants have been described.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|BICD2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal  | author=Hoogenraad CC |title=Mammalian Golgi-associated Bicaudal-D2 functions in the dynein–dynactin pathway by interacting with these complexes |journal=EMBO J. |volume=20 |issue= 15 |pages= 4041–54 |year= 2001 |pmid= 11483508 |doi= 10.1093/emboj/20.15.4041 | pmc=149157  |name-list-format=vanc| author2=Akhmanova A  | author3=Howell SA  | display-authors=3  | last4=Dortland  | first4=BR  | last5=De Zeeuw  | first5=CI  | last6=Willemsen  | first6=R  | last7=Visser  | first7=P  | last8=Grosveld  | first8=F  | last9=Galjart  | first9=N }}
*{{cite journal  | author=Hoogenraad CC, Akhmanova A, Howell SA, ''et al.'' |title=Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4041-54 |year= 2001 |pmid= 11483508 |doi= 10.1093/emboj/20.15.4041 }}
*{{cite journal  | author=Holland PM |title=Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2 |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 16229–40 |year= 2002 |pmid= 11864968 |doi= 10.1074/jbc.M108662200 |name-list-format=vanc| author2=Milne A  | author3=Garka K  | display-authors=3  | last4=Johnson  | first4=RS  | last5=Willis  | first5=C  | last6=Sims  | first6=JE  | last7=Rauch  | first7=CT  | last8=Bird  | first8=TA  | last9=Virca  | first9=GD }}
*{{cite journal  | author=Holland PM, Milne A, Garka K, ''et al.'' |title=Purification, cloning, and characterization of Nek8, a novel NIMA-related kinase, and its candidate substrate Bicd2. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 16229-40 |year= 2002 |pmid= 11864968 |doi= 10.1074/jbc.M108662200 }}
*{{cite journal  | author=Short B |title=The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes |journal=Curr. Biol. |volume=12 |issue= 20 |pages= 1792–5 |year= 2003 |pmid= 12401177 |doi=10.1016/S0960-9822(02)01221-6  |name-list-format=vanc| author2=Preisinger C  | author3=Schaletzky J  | display-authors=3  | last4=Kopajtich  | first4=Robert  | last5=Barr  | first5=Francis A. }}
*{{cite journal  | author=Short B, Preisinger C, Schaletzky J, ''et al.'' |title=The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes. |journal=Curr. Biol. |volume=12 |issue= 20 |pages= 1792-5 |year= 2003 |pmid= 12401177 |doi=  }}
*{{cite journal  | author=Matanis T |title=Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex |journal=Nat. Cell Biol. |volume=4 |issue= 12 |pages= 986–92 |year= 2003 |pmid= 12447383 |doi= 10.1038/ncb891 |name-list-format=vanc| author2=Akhmanova A  | author3=Wulf P  | display-authors=3  | last4=Del Nery  | first4=Elaine  | last5=Weide  | first5=Thomas  | last6=Stepanova  | first6=Tatiana  | last7=Galjart  | first7=Niels  | last8=Grosveld  | first8=Frank  | last9=Goud  | first9=Bruno }}
*{{cite journal  | author=Matanis T, Akhmanova A, Wulf P, ''et al.'' |title=Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex. |journal=Nat. Cell Biol. |volume=4 |issue= 12 |pages= 986-92 |year= 2003 |pmid= 12447383 |doi= 10.1038/ncb891 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hoogenraad CC |title=Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport |journal=EMBO J. |volume=22 |issue= 22 |pages= 6004–15 |year= 2004 |pmid= 14609947 |doi= 10.1093/emboj/cdg592 | pmc=275447  |name-list-format=vanc| author2=Wulf P  | author3=Schiefermeier N  | display-authors=3  | last4=Stepanova  | first4=T  | last5=Galjart  | first5=N  | last6=Small  | first6=JV  | last7=Grosveld  | first7=F  | last8=De Zeeuw  | first8=CI  | last9=Akhmanova  | first9=A }}
*{{cite journal  | author=Hoogenraad CC, Wulf P, Schiefermeier N, ''et al.'' |title=Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport. |journal=EMBO J. |volume=22 |issue= 22 |pages= 6004-15 |year= 2004 |pmid= 14609947 |doi= 10.1093/emboj/cdg592 }}
*{{cite journal  | author=Brill LM |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |name-list-format=vanc| author2=Salomon AR  | author3=Ficarro SB  | display-authors=3  | last4=Mukherji  | first4=Mridul  | last5=Stettler-Gill  | first5=Michelle  | last6=Peters  | first6=Eric C. }}
*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
*{{cite journal  | author=Humphray SJ |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081  |name-list-format=vanc| author2=Oliver K  | author3=Hunt AR  | display-authors=3  | last4=Plumb  | first4=R. W.  | last5=Loveland  | first5=J. E.  | last6=Howe  | first6=K. L.  | last7=Andrews  | first7=T. D.  | last8=Searle  | first8=S.  | last9=Hunt  | first9=S. E. }}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |name-list-format=vanc| author2=Moritz A  | author3=Lee KA  | display-authors=3  | last4=Guo  | first4=Ailan  | last5=Goss  | first5=Valerie L  | last6=Spek  | first6=Erik J  | last7=Zhang  | first7=Hui  | last8=Zha  | first8=Xiang-Ming  | last9=Polakiewicz  | first9=Roberto D }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | vauthors=Fuchs E, Short B, Barr FA |title=Assay and properties of rab6 interaction with dynein-dynactin complexes |journal=Meth. Enzymol. |volume=403 |issue=  |pages= 607–18 |year= 2006 |pmid= 16473624 |doi= 10.1016/S0076-6879(05)03053-3 }}
*{{cite journal  | author=Fuchs E, Short B, Barr FA |title=Assay and properties of rab6 interaction with dynein-dynactin complexes. |journal=Meth. Enzymol. |volume=403 |issue=  |pages= 607-18 |year= 2006 |pmid= 16473624 |doi= 10.1016/S0076-6879(05)03053-3 }}
*{{cite journal  | author=Beausoleil SA |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 |name-list-format=vanc| author2=Villén J  | author3=Gerber SA  | display-authors=3  | last4=Rush  | first4=John  | last5=Gygi  | first5=Steven P }}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 02:35, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein bicaudal D homolog 2 is a protein that in humans is encoded by the BICD2 gene.[1][2]

This gene is one of two human homologs of Drosophila bicaudal-D and a member of the Bicoid family. It has been implicated in dynein-mediated, minus end-directed motility along microtubules. It has also been reported to be a phosphorylation target of NIMA related kinase 8. Two alternative splice variants have been described.[2]

References

  1. ↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  2. ↑ 2.0 2.1 "Entrez Gene: BICD2 bicaudal D homolog 2 (Drosophila)".

External links

Further reading



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