BNIP3L: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like''' is a [[protein]] that in humans is encoded by the ''BNIP3L'' [[gene]].<ref name="pmid9523198">{{cite journal | vauthors = Matsushima M, Fujiwara T, Takahashi E, Minaguchi T, Eguchi Y, Tsujimoto Y, Suzumori K, Nakamura Y | title = Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3 | journal = Genes Chromosomes Cancer | volume = 21 | issue = 3 | pages = 230–5 | date = May 1998 | pmid = 9523198 | pmc =  | doi = 10.1002/(SICI)1098-2264(199803)21:3<230::AID-GCC7>3.0.CO;2-0 }}</ref><ref name="pmid9973195">{{cite journal | vauthors = Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G | title = BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3 | journal = Cancer Res | volume = 59 | issue = 3 | pages = 533–7 | date = Feb 1999 | pmid = 9973195 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=665| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = BCL2/adenovirus E1B 19kDa interacting protein 3-like
| HGNCid = 1085
| Symbol = BNIP3L
| AltSymbols =; BNIP3a; NIX
| OMIM = 605368
| ECnumber = 
| Homologene = 3195
| MGIid = 1332659
| GeneAtlas_image1 = PBB_GE_BNIP3L_221479_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BNIP3L_221478_at_tn.png
| Function = {{GNF_GO|id=GO:0005521 |text = lamin binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005635 |text = nuclear envelope}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005740 |text = mitochondrial envelope}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0008634 |text = negative regulation of survival gene product activity}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0051607 |text = defense response to virus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 665
    | Hs_Ensembl = ENSG00000104765
    | Hs_RefseqProtein = NP_004322
    | Hs_RefseqmRNA = NM_004331
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 26296331
    | Hs_GenLoc_end = 26326562
    | Hs_Uniprot = O60238
    | Mm_EntrezGene = 12177
    | Mm_Ensembl = ENSMUSG00000022051
    | Mm_RefseqmRNA = NM_009761
    | Mm_RefseqProtein = NP_033891
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 65939349
    | Mm_GenLoc_end = 65962966
    | Mm_Uniprot = Q3TEW0
  }}
}}
'''BCL2/adenovirus E1B 19kDa interacting protein 3-like''', also known as '''BNIP3L''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=665| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family.  It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector.  The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein.  This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family.  It interacts with the E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector.  The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein.  This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.<ref name="entrez">{{cite web | title = Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=665| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
BNIP3L has been shown to [[Protein-protein interaction|interact]] with [[STEAP3]].<ref name=pmid12606722>{{cite journal | vauthors = Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A | title = The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase | journal = [[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] | volume = 100 | issue = 5 | pages = 2284–9 | date = Mar 2003 | pmid = 12606722 | pmc = 151332 | doi = 10.1073/pnas.0530298100 }}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|BNIP3L}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chen G, Cizeau J, Vande Velde C, Park JH, Bozek G, Bolton J, Shi L, Dubik D, Greenberg A | title = Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. | journal = J. Biol. Chem. | volume = 274 | issue = 1 | pages = 7–10 | year = 1999 | pmid = 9867803 | doi = 10.1074/jbc.274.1.7 }}
| citations =
* {{cite journal | vauthors = Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, Motoyama N, Nakajima T | title = A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. | journal = Cell Death Differ. | volume = 6 | issue = 4 | pages = 314–25 | year = 1999 | pmid = 10381623 | doi = 10.1038/sj.cdd.4400493 }}
*{{cite journal  | author=Matsushima M, Fujiwara T, Takahashi E, ''et al.'' |title=Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. |journal=Genes Chromosomes Cancer |volume=21 |issue= 3 |pages= 230-5 |year= 1998 |pmid= 9523198 |doi=  }}
* {{cite journal | vauthors = Imazu T, Shimizu S, Tagami S, Matsushima M, Nakamura Y, Miki T, Okuyama A, Tsujimoto Y | title = Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. | journal = Oncogene | volume = 18 | issue = 32 | pages = 4523–9 | year = 1999 | pmid = 10467396 | doi = 10.1038/sj.onc.1202722 }}
*{{cite journal | author=Chen G, Cizeau J, Vande Velde C, ''et al.'' |title=Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. |journal=J. Biol. Chem. |volume=274 |issue= 1 |pages= 7-10 |year= 1999 |pmid= 9867803 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal  | author=Yasuda M, Han JW, Dionne CA, ''et al.'' |title=BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3. |journal=Cancer Res. |volume=59 |issue= 3 |pages= 533-7 |year= 1999 |pmid= 9973195 |doi=  }}
* {{cite journal | vauthors = Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A | title = The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 5 | pages = 2284–9 | year = 2003 | pmid = 12606722 | pmc = 151332 | doi = 10.1073/pnas.0530298100 }}
*{{cite journal | author=Ohi N, Tokunaga A, Tsunoda H, ''et al.'' |title=A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region. |journal=Cell Death Differ. |volume=6 |issue= 4 |pages= 314-25 |year= 1999 |pmid= 10381623 |doi= 10.1038/sj.cdd.4400493 }}
* {{cite journal | vauthors = Aerbajinai W, Giattina M, Lee YT, Raffeld M, Miller JL | title = The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. | journal = Blood | volume = 102 | issue = 2 | pages = 712–7 | year = 2003 | pmid = 12663450 | doi = 10.1182/blood-2002-11-3324 }}
*{{cite journal | author=Imazu T, Shimizu S, Tagami S, ''et al.'' |title=Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. |journal=Oncogene |volume=18 |issue= 32 |pages= 4523-9 |year= 1999 |pmid= 10467396 |doi= 10.1038/sj.onc.1202722 }}
* {{cite journal | vauthors = Sun JL, He XS, Yu YH, Chen ZC | title = [Expression and structure of BNIP3L in lung cancer] | journal = Ai Zheng | volume = 23 | issue = 1 | pages = 8–14 | year = 2004 | pmid = 14720367 | doi =  }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Fei P, Wang W, Kim SH, Wang S, Burns TF, Sax JK, Buzzai M, Dicker DT, McKenna WG, Bernhard EJ, El-Deiry WS | title = Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. | journal = Cancer Cell | volume = 6 | issue = 6 | pages = 597–609 | year = 2005 | pmid = 15607964 | doi = 10.1016/j.ccr.2004.10.012 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Stepan H, Leo C, Purz S, Höckel M, Horn LC | title = Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. | journal = Eur. J. Obstet. Gynecol. Reprod. Biol. | volume = 122 | issue = 2 | pages = 172–6 | year = 2006 | pmid = 16219518 | doi = 10.1016/j.ejogrb.2005.01.017 }}
*{{cite journal | author=Passer BJ, Nancy-Portebois V, Amzallag N, ''et al.'' |title=The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2284-9 |year= 2003 |pmid= 12606722 |doi= 10.1073/pnas.0530298100 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Aerbajinai W, Giattina M, Lee YT, ''et al.'' |title=The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. |journal=Blood |volume=102 |issue= 2 |pages= 712-7 |year= 2003 |pmid= 12663450 |doi= 10.1182/blood-2002-11-3324 }}
*{{cite journal | author=Sun JL, He XS, Yu YH, Chen ZC |title=[Expression and structure of BNIP3L in lung cancer] |journal=Ai Zheng |volume=23 |issue= 1 |pages= 8-14 |year= 2004 |pmid= 14720367 |doi=  }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Fei P, Wang W, Kim SH, ''et al.'' |title=Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth. |journal=Cancer Cell |volume=6 |issue= 6 |pages= 597-609 |year= 2005 |pmid= 15607964 |doi= 10.1016/j.ccr.2004.10.012 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Stepan H, Leo C, Purz S, ''et al.'' |title=Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. |journal=Eur. J. Obstet. Gynecol. Reprod. Biol. |volume=122 |issue= 2 |pages= 172-6 |year= 2006 |pmid= 16219518 |doi= 10.1016/j.ejogrb.2005.01.017 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:27, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like is a protein that in humans is encoded by the BNIP3L gene.[1][2][3]

Function

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.[3]

Interactions

BNIP3L has been shown to interact with STEAP3.[4]

References

  1. ↑ Matsushima M, Fujiwara T, Takahashi E, Minaguchi T, Eguchi Y, Tsujimoto Y, Suzumori K, Nakamura Y (May 1998). "Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3". Genes Chromosomes Cancer. 21 (3): 230–5. doi:10.1002/(SICI)1098-2264(199803)21:3<230::AID-GCC7>3.0.CO;2-0. PMID 9523198.
  2. ↑ Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G (Feb 1999). "BNIP3alpha: a human homolog of mitochondrial proapoptotic protein BNIP3". Cancer Res. 59 (3): 533–7. PMID 9973195.
  3. ↑ 3.0 3.1 "Entrez Gene: BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like".
  4. ↑ Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (Mar 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.

External links

Further reading


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