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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein BTG1''' is a [[protein]] that in humans is encoded by the ''BTG1'' [[gene]].<ref name="pmid15033446">{{cite journal | vauthors = Iwai K, Hirata K, Ishida T, Takeuchi S, Hirase T, Rikitake Y, Kojima Y, Inoue N, Kawashima S, Yokohama M | display-authors = 6 | title = An anti-proliferative gene BTG1 regulates angiogenesis in vitro | journal = Biochemical and Biophysical Research Communications | volume = 316 | issue = 3 | pages = 628–35 | date = April 2004 | pmid = 15033446 | pmc =  | doi = 10.1016/j.bbrc.2004.02.095 }}</ref><ref name="entrez">{{cite web  | title = Entrez Gene: BTG1 B-cell translocation gene 1, anti-proliferative| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=694| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = B-cell translocation gene 1, anti-proliferative
| HGNCid = 1130
| Symbol = BTG1
| AltSymbols =;
| OMIM = 109580
| ECnumber = 
| Homologene = 37521
| MGIid = 88215
| GeneAtlas_image1 = PBB_GE_BTG1_200921_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_BTG1_200920_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003712 |text = transcription cofactor activity}} {{GNF_GO|id=GO:0019900 |text = kinase binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006479 |text = protein amino acid methylation}} {{GNF_GO|id=GO:0007286 |text = spermatid development}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030308 |text = negative regulation of cell growth}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0043085 |text = positive regulation of enzyme activity}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045603 |text = positive regulation of endothelial cell differentiation}} {{GNF_GO|id=GO:0045663 |text = positive regulation of myoblast differentiation}} {{GNF_GO|id=GO:0045766 |text = positive regulation of angiogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 694
    | Hs_Ensembl = ENSG00000133639
    | Hs_RefseqProtein = NP_001722
    | Hs_RefseqmRNA = NM_001731
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 91061030
    | Hs_GenLoc_end = 91063751
    | Hs_Uniprot = P62324
    | Mm_EntrezGene = 12226
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_007569
    | Mm_RefseqProtein = NP_031595
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''B-cell translocation gene 1, anti-proliferative''', also known as '''BTG1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BTG1 B-cell translocation gene 1, anti-proliferative| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=694| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) [[chromosomal translocation]] in a case of [[B-cell chronic lymphocytic leukemia]]. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the [[cell cycle]] and downregulated when cells progressed through G1. It negatively regulates [[cell proliferation]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation.<ref name="entrez">{{cite web | title = Entrez Gene: BTG1 B-cell translocation gene 1, anti-proliferative| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=694| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
BTG1 has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
* [[CNOT7]],<ref name = pmid9820826>{{cite journal | vauthors = Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB | display-authors = 6 | title = Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1 | journal = The Biochemical Journal | volume = 336 ( Pt 2) | issue = 2 | pages = 471–81 | date = December 1998 | pmid = 9820826 | pmc = 1219893 | doi =  | series = 336 }}</ref><ref name = pmid11136725>{{cite journal | vauthors = Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L | display-authors = 6 | title = Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 9640–8 | date = March 2001 | pmid = 11136725 | doi = 10.1074/jbc.M008201200 }}</ref>
{{PBB_Further_reading
* [[CNOT8]],<ref name = pmid11136725/><ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | display-authors = 6 | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
| citations =
* [[HOXB9]],<ref name = pmid10617598>{{cite journal | vauthors = Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L | display-authors = 6 | title = The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation | journal = The Journal of Biological Chemistry | volume = 275 | issue = 1 | pages = 147–53 | date = January 2000 | pmid = 10617598 | doi = 10.1074/jbc.275.1.147 }}</ref>  and
*{{cite journal  | author=Rouault JP, Rimokh R, Tessa C, ''et al.'' |title=BTG1, a member of a new family of antiproliferative genes. |journal=EMBO J. |volume=11 |issue= 4 |pages= 1663-70 |year= 1992 |pmid= 1373383 |doi= }}
* [[PRMT1]].<ref name = pmid8663146>{{cite journal | vauthors = Lin WJ, Gary JD, Yang MC, Clarke S, Herschman HR | title = The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 25 | pages = 15034–44 | date = June 1996 | pmid = 8663146 | doi = 10.1074/jbc.271.25.15034 }}</ref><ref name = pmid11856371>{{cite journal | vauthors = Berthet C, Guéhenneux F, Revol V, Samarut C, Lukaszewicz A, Dehay C, Dumontet C, Magaud JP, Rouault JP | display-authors = 6 | title = Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects | journal = Genes to Cells | volume = 7 | issue = 1 | pages = 29–39 | date = January 2002 | pmid = 11856371 | doi = 10.1046/j.1356-9597.2001.00497.x }}</ref>
*{{cite journal | author=Rimokh R, Rouault JP, Wahbi K, ''et al.'' |title=A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia. |journal=Genes Chromosomes Cancer |volume=3 |issue= 1 |pages= 24-36 |year= 1991 |pmid= 2069907 |doi= }}
 
*{{cite journal | author=Lin WJ, Gary JD, Yang MC, ''et al.'' |title=The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15034-44 |year= 1996 |pmid= 8663146 |doi= }}
== Clinical relevance ==
*{{cite journal  | author=Corjay MH, Kearney MA, Munzer DA, ''et al.'' |title=Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human. |journal=Lab. Invest. |volume=78 |issue= 7 |pages= 847-58 |year= 1998 |pmid= 9690562 |doi=  }}
 
*{{cite journal | author=Bogdan JA, Adams-Burton C, Pedicord DL, ''et al.'' |title=Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1. |journal=Biochem. J. |volume=336 ( Pt 2) |issue= |pages= 471-81 |year= 1999 |pmid= 9820826 |doi= }}
Recurrent mutations in this gene have been associated to cases of [[diffuse large B-cell lymphoma]].<ref name="pmid21796119">{{cite journal | vauthors = Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA | display-authors = 6 | title = Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma | journal = Nature | volume = 476 | issue = 7360 | pages = 298–303 | date = August 2011 | pmid = 21796119 | pmc = 3210554 | doi = 10.1038/nature10351 }}</ref><ref name="pmid22343534">{{cite journal | vauthors = Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR | display-authors = 6 | title = Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 109 | issue = 10 | pages = 3879–84 | date = March 2012 | pmid = 22343534 | pmc = 3309757 | doi = 10.1073/pnas.1121343109 }}</ref>
*{{cite journal | author=Prévôt D, Voeltzel T, Birot AM, ''et al.'' |title=The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 147-53 |year= 2000 |pmid= 10617598 |doi= }}
 
*{{cite journal | author=Prévôt D, Morel AP, Voeltzel T, ''et al.'' |title=Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 9640-8 |year= 2001 |pmid= 11136725 |doi= 10.1074/jbc.M008201200 }}
== Maintenance of adult neural stem cells ==
*{{cite journal | author=Rodier A, Rochard P, Berthet C, ''et al.'' |title=Identification of functional domains involved in BTG1 cell localization. |journal=Oncogene |volume=20 |issue= 21 |pages= 2691-703 |year= 2001 |pmid= 11420681 |doi= 10.1038/sj.onc.1204398 }}
 
*{{cite journal  | author=Yoshida Y, Hosoda E, Nakamura T, Yamamoto T |title=Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. |journal=Jpn. J. Cancer Res. |volume=92 |issue= 6 |pages= 592-6 |year= 2001 |pmid= 11429045 |doi= }}
Recent data, obtained in a new model of mouse lacking the BTG1 gene, indicate that BTG1 is essential for the proliferation and expansion of stem cells in the adult neurogenic niches, i.e. the dentate gyrus and sub ventricular zone (see for review<ref>{{cite journal | vauthors = Micheli L, Ceccarelli M, Farioli-Vecchioli S, Tirone F  | title = Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 Genes - Review | journal = Journal of Cellular Physiology | volume = 230 | issue = 12 | pages = 2881–90 | date = December 2015 | pmid = 25967096 | doi = 10.1002/jcp.25038 |url=http://www.inmm.cnr.it/tirone/pdfs/Btg1%20Btg2%20review%20Micheli%20Tirone%20J%20Cell%20Physiol%202015.pdf}}</ref>). In particular, BTG1 keeps adult neural stem cells in quiescence, preserving the neural stem cells pool from depletion. In the absence of BTG1, the stem and progenitor cells initially hyper proliferate and then in the longer period lose the ability to proliferate and expand.<ref name="pmid22969701">{{cite journal | vauthors = Farioli-Vecchioli S, Micheli L, Saraulli D, Ceccarelli M, Cannas S, Scardigli R, Leonardi L, Cinà I, Costanzi M, Ciotti MT, Moreira P, Rouault JP, Cestari V, Tirone F | display-authors = 6 | title = Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone | journal = Frontiers in Neuroscience | volume = 6 | issue =  | pages = 124 | year = 2012 | pmid = 22969701 | pmc = 3431174 | doi = 10.3389/fnins.2012.00124 }}</ref><ref name="pmid23734097">{{cite journal | vauthors = Tirone F, Farioli-Vecchioli S, Micheli L, Ceccarelli M, Leonardi L | title = Genetic control of adult neurogenesis: interplay of differentiation, proliferation and survival modulates new neurons function, and memory circuits - Review | journal = Frontiers in Cellular Neuroscience | volume = 7 | issue = | pages = 59 | year = 2013 | pmid = 23734097 | pmc = 3653098 | doi = 10.3389/fncel.2013.00059 }}</ref> Other recent data indicate that physical exercise can fully reconstitute the proliferative defect of stem cells that follows the ablation of the BTG1 gene, suggesting that the pool of neural stem cells maintains a hidden form of plasticity which is tightly controlled by BTG1; hence, BTG1 might prevent the depletion of stem cells in the presence of strong neurogenic stimuli or of neural degenerative stimuli.<ref>{{cite journal | vauthors = Farioli-Vecchioli S, Mattera A, Micheli L, Ceccarelli M, Leonardi L, Saraulli D, Costanzi M, Cestari V, Rouault JP, Tirone F | display-authors = 6 | title = Running rescues defective adult neurogenesis by shortening the length of the cell cycle of neural stem and progenitor cells | journal = Stem Cells | volume = 32 | issue = 7 | pages = 1968–82 | date = July 2014 | pmid = 24604711  | doi = 10.1002/stem.1679 }}</ref><ref>{{cite journal | vauthors = Farioli-Vecchioli S, Tirone F | title = Control of the cell cycle in adult neurogenesis and its relation with physical exercise - Review | journal = Brain Plasticity | volume = 1 | issue = 1 | pages = 41–54 | date = July 2015 | doi = 10.3233/BPL-150013 | url =http://content.iospress.com/download/brain-plasticity/bpl150013?id=brain-plasticity%2Fbpl150013}}</ref>
*{{cite journal | author=Berthet C, Guéhenneux F, Revol V, ''et al.'' |title=Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects. |journal=Genes Cells |volume=7 |issue= 1 |pages= 29-39 |year= 2002 |pmid= 11856371 |doi=  }}
 
*{{cite journal  | author=Sasajima H, Nakagawa K, Yokosawa H |title=Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. |journal=Eur. J. Biochem. |volume=269 |issue= 14 |pages= 3596-604 |year= 2002 |pmid= 12135500 |doi= }}
Btg1 plays a role also in the expansion of cerebellar granule precursor cells. In fact the deletion of Btg1 leads in mouse to uncontrolled proliferation of the cerebellar precursor cells during the early postnatal period. Consequently, in the adult, the cerebellum lacking Btg1 is significantly larger and the motor coordination is heavily impaired.<ref>{{cite journal | vauthors = Ceccarelli M, Micheli L, D'Andrea G, De Bardi M, Scheijen B, Ciotti M, Leonardi L, Luvisetto S, Tirone F | display-authors = 6 | title = Altered cerebellum development and impaired motor coordination in mice lacking the Btg1 gene: Involvement of cyclin D1 | journal = Developmental Biology | volume = 408 | issue = 1 | pages = 109–25 | date = December 2015 | pmid = 26524254 | doi = 10.1016/j.ydbio.2015.10.007 }}</ref>
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
 
*{{cite journal  | author=Bakker WJ, Blázquez-Domingo M, Kolbus A, ''et al.'' |title=FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. |journal=J. Cell Biol. |volume=164 |issue= 2 |pages= 175-84 |year= 2004 |pmid= 14734530 |doi= 10.1083/jcb.200307056 }}
The closest homolog of BTG1 is [[BTG2]], which also controls the proliferation and differentiation of adult neural stem cells; the role of [[BTG2]], however, appears to differ from that of BTG1 being probably more relevant in controlling the terminal differentiation  of neural stem and progenitor cells in the adult neurogenic niches.<ref name="pmid23734097"/>
*{{cite journal | author=Iwai K, Hirata K, Ishida T, ''et al.'' |title=An anti-proliferative gene BTG1 regulates angiogenesis in vitro. |journal=Biochem. Biophys. Res. Commun. |volume=316 |issue= 3 |pages= 628-35 |year= 2004 |pmid= 15033446 |doi= 10.1016/j.bbrc.2004.02.095 }}
{{clear}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
 
*{{cite journal | author=Busson M, Carazo A, Seyer P, ''et al.'' |title=Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation. |journal=Oncogene |volume=24 |issue= 10 |pages= 1698-710 |year= 2005 |pmid= 15674337 |doi= 10.1038/sj.onc.1208373 }}
== References ==
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
{{reflist|35em}}
}}
 
==External links==
* {{UCSC gene info|BTG1}}
 
== Further reading ==
{{refbegin|35em}}
* {{cite journal | vauthors = Rouault JP, Rimokh R, Tessa C, Paranhos G, Ffrench M, Duret L, Garoccio M, Germain D, Samarut J, Magaud JP | display-authors = 6 | title = BTG1, a member of a new family of antiproliferative genes | journal = The EMBO Journal | volume = 11 | issue = 4 | pages = 1663–70 | date = April 1992 | pmid = 1373383 | pmc = 556617 | doi =  }}
* {{cite journal | vauthors = Rimokh R, Rouault JP, Wahbi K, Gadoux M, Lafage M, Archimbaud E, Charrin C, Gentilhomme O, Germain D, Samarut J | display-authors = 6 | title = A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia | journal = Genes, Chromosomes & Cancer | volume = 3 | issue = 1 | pages = 24–36 | date = January 1991 | pmid = 2069907 | doi = 10.1002/gcc.2870030106 }}
* {{cite journal | vauthors = Corjay MH, Kearney MA, Munzer DA, Diamond SM, Stoltenborg JK | title = Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 78 | issue = 7 | pages = 847–58 | date = July 1998 | pmid = 9690562 | doi =  }}
* {{cite journal | vauthors = Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, Stoltenborg JK, Dicker IB | display-authors = 6 | title = Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1 | journal = The Biochemical Journal | volume = 336 ( Pt 2) | issue =  | pages = 471–81 | date = December 1998 | pmid = 9820826 | pmc = 1219893 | doi =  | series = 336 }}
* {{cite journal | vauthors = Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, Corbo L | display-authors = 6 | title = The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation | journal = The Journal of Biological Chemistry | volume = 275 | issue = 1 | pages = 147–53 | date = January 2000 | pmid = 10617598 | doi = 10.1074/jbc.275.1.147 }}
* {{cite journal | vauthors = Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, Corbo L | display-authors = 6 | title = Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 9640–8 | date = March 2001 | pmid = 11136725 | doi = 10.1074/jbc.M008201200 }}
* {{cite journal | vauthors = Rodier A, Rochard P, Berthet C, Rouault JP, Casas F, Daury L, Busson M, Magaud JP, Wrutniak-Cabello C, Cabello G | display-authors = 6 | title = Identification of functional domains involved in BTG1 cell localization | journal = Oncogene | volume = 20 | issue = 21 | pages = 2691–703 | date = May 2001 | pmid = 11420681 | doi = 10.1038/sj.onc.1204398 }}
* {{cite journal | vauthors = Yoshida Y, Hosoda E, Nakamura T, Yamamoto T | title = Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex | journal = Japanese Journal of Cancer Research | volume = 92 | issue = 6 | pages = 592–6 | date = June 2001 | pmid = 11429045 | doi = 10.1111/j.1349-7006.2001.tb01135.x }}
* {{cite journal | vauthors = Berthet C, Guéhenneux F, Revol V, Samarut C, Lukaszewicz A, Dehay C, Dumontet C, Magaud JP, Rouault JP | display-authors = 6 | title = Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects | journal = Genes to Cells | volume = 7 | issue = 1 | pages = 29–39 | date = January 2002 | pmid = 11856371 | doi = 10.1046/j.1356-9597.2001.00497.x }}
* {{cite journal | vauthors = Sasajima H, Nakagawa K, Yokosawa H | title = Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 14 | pages = 3596–604 | date = July 2002 | pmid = 12135500 | doi = 10.1046/j.1432-1033.2002.03052.x }}
* {{cite journal | vauthors = Bakker WJ, Blázquez-Domingo M, Kolbus A, Besooyen J, Steinlein P, Beug H, Coffer PJ, Löwenberg B, von Lindern M, van Dijk TB | display-authors = 6 | title = FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1 | journal = The Journal of Cell Biology | volume = 164 | issue = 2 | pages = 175–84 | date = January 2004 | pmid = 14734530 | pmc = 2172323 | doi = 10.1083/jcb.200307056 }}
* {{cite journal | vauthors = Busson M, Carazo A, Seyer P, Grandemange S, Casas F, Pessemesse L, Rouault JP, Wrutniak-Cabello C, Cabello G | display-authors = 6 | title = Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation | journal = Oncogene | volume = 24 | issue = 10 | pages = 1698–710 | date = March 2005 | pmid = 15674337 | doi = 10.1038/sj.onc.1208373 }}
{{refend}}
{{refend}}


{{protein-stub}}
[[Category:Oncogenes]]
{{WikiDoc Sources}}

Revision as of 17:40, 5 December 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Protein BTG1 is a protein that in humans is encoded by the BTG1 gene.[1][2]

Function

The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation.[2]

Interactions

BTG1 has been shown to interact with:

Clinical relevance

Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[9][10]

Maintenance of adult neural stem cells

Recent data, obtained in a new model of mouse lacking the BTG1 gene, indicate that BTG1 is essential for the proliferation and expansion of stem cells in the adult neurogenic niches, i.e. the dentate gyrus and sub ventricular zone (see for review[11]). In particular, BTG1 keeps adult neural stem cells in quiescence, preserving the neural stem cells pool from depletion. In the absence of BTG1, the stem and progenitor cells initially hyper proliferate and then in the longer period lose the ability to proliferate and expand.[12][13] Other recent data indicate that physical exercise can fully reconstitute the proliferative defect of stem cells that follows the ablation of the BTG1 gene, suggesting that the pool of neural stem cells maintains a hidden form of plasticity which is tightly controlled by BTG1; hence, BTG1 might prevent the depletion of stem cells in the presence of strong neurogenic stimuli or of neural degenerative stimuli.[14][15]

Btg1 plays a role also in the expansion of cerebellar granule precursor cells. In fact the deletion of Btg1 leads in mouse to uncontrolled proliferation of the cerebellar precursor cells during the early postnatal period. Consequently, in the adult, the cerebellum lacking Btg1 is significantly larger and the motor coordination is heavily impaired.[16]

The closest homolog of BTG1 is BTG2, which also controls the proliferation and differentiation of adult neural stem cells; the role of BTG2, however, appears to differ from that of BTG1 being probably more relevant in controlling the terminal differentiation of neural stem and progenitor cells in the adult neurogenic niches.[13]

References

  1. ↑ Iwai K, Hirata K, Ishida T, Takeuchi S, Hirase T, Rikitake Y, et al. (April 2004). "An anti-proliferative gene BTG1 regulates angiogenesis in vitro". Biochemical and Biophysical Research Communications. 316 (3): 628–35. doi:10.1016/j.bbrc.2004.02.095. PMID 15033446.
  2. ↑ 2.0 2.1 "Entrez Gene: BTG1 B-cell translocation gene 1, anti-proliferative".
  3. ↑ Bogdan JA, Adams-Burton C, Pedicord DL, Sukovich DA, Benfield PA, Corjay MH, et al. (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". The Biochemical Journal. 336. 336 ( Pt 2) (2): 471–81. PMC 1219893. PMID 9820826.
  4. ↑ 4.0 4.1 Prévôt D, Morel AP, Voeltzel T, Rostan MC, Rimokh R, Magaud JP, et al. (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". The Journal of Biological Chemistry. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
  5. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  6. ↑ Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP, et al. (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". The Journal of Biological Chemistry. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598.
  7. ↑ Lin WJ, Gary JD, Yang MC, Clarke S, Herschman HR (June 1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase". The Journal of Biological Chemistry. 271 (25): 15034–44. doi:10.1074/jbc.271.25.15034. PMID 8663146.
  8. ↑ Berthet C, Guéhenneux F, Revol V, Samarut C, Lukaszewicz A, Dehay C, et al. (January 2002). "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects". Genes to Cells. 7 (1): 29–39. doi:10.1046/j.1356-9597.2001.00497.x. PMID 11856371.
  9. ↑ Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, et al. (August 2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature. 476 (7360): 298–303. doi:10.1038/nature10351. PMC 3210554. PMID 21796119.
  10. ↑ Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, et al. (March 2012). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America. 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.
  11. ↑ Micheli L, Ceccarelli M, Farioli-Vecchioli S, Tirone F (December 2015). "Control of the Normal and Pathological Development of Neural Stem and Progenitor Cells by the PC3/Tis21/Btg2 and Btg1 Genes - Review" (PDF). Journal of Cellular Physiology. 230 (12): 2881–90. doi:10.1002/jcp.25038. PMID 25967096.
  12. ↑ Farioli-Vecchioli S, Micheli L, Saraulli D, Ceccarelli M, Cannas S, Scardigli R, et al. (2012). "Btg1 is Required to Maintain the Pool of Stem and Progenitor Cells of the Dentate Gyrus and Subventricular Zone". Frontiers in Neuroscience. 6: 124. doi:10.3389/fnins.2012.00124. PMC 3431174. PMID 22969701.
  13. ↑ 13.0 13.1 Tirone F, Farioli-Vecchioli S, Micheli L, Ceccarelli M, Leonardi L (2013). "Genetic control of adult neurogenesis: interplay of differentiation, proliferation and survival modulates new neurons function, and memory circuits - Review". Frontiers in Cellular Neuroscience. 7: 59. doi:10.3389/fncel.2013.00059. PMC 3653098. PMID 23734097.
  14. ↑ Farioli-Vecchioli S, Mattera A, Micheli L, Ceccarelli M, Leonardi L, Saraulli D, et al. (July 2014). "Running rescues defective adult neurogenesis by shortening the length of the cell cycle of neural stem and progenitor cells". Stem Cells. 32 (7): 1968–82. doi:10.1002/stem.1679. PMID 24604711.
  15. ↑ Farioli-Vecchioli S, Tirone F (July 2015). "Control of the cell cycle in adult neurogenesis and its relation with physical exercise - Review". Brain Plasticity. 1 (1): 41–54. doi:10.3233/BPL-150013.
  16. ↑ Ceccarelli M, Micheli L, D'Andrea G, De Bardi M, Scheijen B, Ciotti M, et al. (December 2015). "Altered cerebellum development and impaired motor coordination in mice lacking the Btg1 gene: Involvement of cyclin D1". Developmental Biology. 408 (1): 109–25. doi:10.1016/j.ydbio.2015.10.007. PMID 26524254.

External links

Further reading

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