CGB2 (gene): Difference between revisions

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{{Infobox_gene}}
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'''Choriogonadotropin subunit beta variant 2''' is a [[protein]] that in humans is encoded by the ''CGB2'' [[gene]].<ref name="pmid6194155">{{cite journal | vauthors = Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I | title = The beta subunit of human chorionic gonadotropin is encoded by multiple genes | journal = J Biol Chem | volume = 258 | issue = 19 | pages = 11492–9 | date =Nov 1983 | pmid = 6194155 | pmc =  | doi =}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CGB2 chorionic gonadotropin, beta polypeptide 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114336| accessdate =}}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_CGB2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1hcn.
| PDB = {{PDB2|1hcn}}, {{PDB2|1hrp}}, {{PDB2|1qfw}}
| Name = Chorionic gonadotropin, beta polypeptide 2
| HGNCid = 16722
| Symbol = CGB2
| AltSymbols =;
| OMIM = 608824
| ECnumber = 
| Homologene = 
| MGIid = 
| GeneAtlas_image1 = PBB_GE_CGB2_205387_s_at_tn.png
| Function =
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 114336
    | Hs_Ensembl = ENSG00000104818
    | Hs_RefseqProtein = NP_203696
    | Hs_RefseqmRNA = NM_033378
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 54226942
    | Hs_GenLoc_end = 54228307
    | Hs_Uniprot =
    | Mm_EntrezGene =   
    | Mm_Ensembl =
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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'''Chorionic gonadotropin, beta polypeptide 2''', also known as '''CGB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CGB2 chorionic gonadotropin, beta polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114336| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.<ref name="entrez">{{cite web | title = Entrez Gene: CGB2 chorionic gonadotropin, beta polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114336| accessdate = }}</ref>
| summary_text = The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in [[tandem]] and inverted pairs on chromosome 19q13.3, and contiguous with the [[luteinizing hormone]] beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two [[pseudogene]]s (CGB1 and CGB2) of CGB subunit, however, detection of [[CGB1]] and CGB2 transcripts in vivo, and their presence on the [[polysome]]s, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits {{PMID|8954017}}. However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CGB2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bo M, Boime I |title=Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3179-84 |year= 1992 |pmid= 1371113 |doi=  }}
*{{cite journal  | vauthors=Bo M, Boime I |title=Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo |journal=J. Biol. Chem. |volume=267 |issue= 5 |pages= 3179–84 |year= 1992 |pmid= 1371113 |doi=  }}
*{{cite journal  | author=Policastro PF, Daniels-McQueen S, Carle G, Boime I |title=A map of the hCG beta-LH beta gene cluster. |journal=J. Biol. Chem. |volume=261 |issue= 13 |pages= 5907-16 |year= 1986 |pmid= 2422163 |doi=  }}
*{{cite journal  | vauthors=Policastro PF, Daniels-McQueen S, Carle G, Boime I |title=A map of the hCG beta-LH beta gene cluster |journal=J. Biol. Chem. |volume=261 |issue= 13 |pages= 5907–16 |year= 1986 |pmid= 2422163 |doi=  }}
*{{cite journal  | author=Policastro P, Ovitt CE, Hoshina M, ''et al.'' |title=The beta subunit of human chorionic gonadotropin is encoded by multiple genes. |journal=J. Biol. Chem. |volume=258 |issue= 19 |pages= 11492-9 |year= 1983 |pmid= 6194155 |doi=  }}
*{{cite journal  | author=Julier C |title=The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19 |journal=Hum. Genet. |volume=67 |issue= 2 |pages= 174–177 |year= 1984 |pmid= 6204923 |doi=10.1007/BF00272995 |name-list-format=vanc| author2=Weil D | author3=Couillin P | display-authors=3  | last4=ct??? | first4=J. C. | last5=Nguyen  | first5=Cong  | last6=Foubert  | first6=C.  | last7=Bou??  | first7=A.  | last8=Thirion  | first8=J. P.  | last9=Kaplan | first9=J. C. }}
*{{cite journal  | author=Julier C, Weil D, Couillin P, ''et al.'' |title=The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19. |journal=Hum. Genet. |volume=67 |issue= 2 |pages= 174-7 |year= 1984 |pmid= 6204923 |doi=  }}
*{{cite journal  | vauthors=Talmadge K, Boorstein WR, Fiddes JC |title=The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone |journal=DNA |volume=2 |issue= 4 |pages= 281–289 |year= 1984 |pmid= 6319099 |doi=10.1089/dna.1983.2.281 }}
*{{cite journal  | author=Talmadge K, Boorstein WR, Fiddes JC |title=The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone. |journal=DNA |volume=2 |issue= 4 |pages= 281-9 |year= 1984 |pmid= 6319099 |doi=  }}
*{{cite journal  | vauthors=Talmadge K, Vamvakopoulos NC, Fiddes JC |title=Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone |journal=Nature |volume=307 |issue= 5946 |pages= 37–40 |year= 1984 |pmid= 6690982 |doi=10.1038/307037a0 }}
*{{cite journal  | author=Talmadge K, Vamvakopoulos NC, Fiddes JC |title=Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. |journal=Nature |volume=307 |issue= 5946 |pages= 37-40 |year= 1984 |pmid= 6690982 |doi=  }}
*{{cite journal  | author=Dirnhofer S |title=Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1 |journal=J. Clin. Endocrinol. Metab. |volume=81 |issue= 12 |pages= 4212–4217 |year= 1997 |pmid= 8954017 |doi=10.1210/jc.81.12.4212  |name-list-format=vanc| author2=Hermann M  | author3=Hittmair A  | display-authors=3  | last4=Hoermann  | first4=R  | last5=Kapelari  | first5=K  | last6=Berger  | first6=P }}
*{{cite journal  | author=Dirnhofer S, Hermann M, Hittmair A, ''et al.'' |title=Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1. |journal=J. Clin. Endocrinol. Metab. |volume=81 |issue= 12 |pages= 4212-7 |year= 1997 |pmid= 8954017 |doi=  }}
*{{cite journal  | author=Venter JC |title=The sequence of the human genome |journal=Science |volume=291 |issue= 5507 |pages= 1304–1351 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 |name-list-format=vanc| author2=Adams MD  | author3=Myers EW  | display-authors=3  | last4=Li  | first4=PW  | last5=Mural  | first5=RJ  | last6=Sutton  | first6=GG  | last7=Smith  | first7=HO  | last8=Yandell  | first8=M  | last9=Evans  | first9=CA }}
*{{cite journal  | author=Venter JC, Adams MD, Myers EW, ''et al.'' |title=The sequence of the human genome. |journal=Science |volume=291 |issue= 5507 |pages= 1304-51 |year= 2001 |pmid= 11181995 |doi= 10.1126/science.1058040 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Hallast P, Rull K, Laan M |title=The evolution and genomic landscape of CGB1 and CGB2 genes |journal=Mol. Cell. Endocrinol. |volume=260-262 |issue=  |pages= 2–11 |year= 2007 |pmid= 17055150 |doi= 10.1016/j.mce.2005.11.049 | pmc=2599907 }}
*{{cite journal  | author=Hallast P, Rull K, Laan M |title=The evolution and genomic landscape of CGB1 and CGB2 genes. |journal=Mol. Cell. Endocrinol. |volume=260-262 |issue=  |pages= 2-11 |year= 2007 |pmid= 17055150 |doi= 10.1016/j.mce.2005.11.049 }}
}}
}}
{{refend}}


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{{PDB Gallery|geneid=114336}}
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Latest revision as of 09:37, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Choriogonadotropin subunit beta variant 2 is a protein that in humans is encoded by the CGB2 gene.[1][2]

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits PMID 8954017. However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.[2]

References

  1. ↑ Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (Nov 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J Biol Chem. 258 (19): 11492–9. PMID 6194155.
  2. ↑ 2.0 2.1 "Entrez Gene: CGB2 chorionic gonadotropin, beta polypeptide 2".

External links

Further reading



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