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{{ | '''E3 ubiquitin-protein ligase CHFR''' is an [[enzyme]] that in humans is encoded by the ''CHFR'' [[gene]].<ref name="pmid10935642">{{cite journal | vauthors = Scolnick DM, Halazonetis TD | title = Chfr defines a mitotic stress checkpoint that delays entry into metaphase | journal = Nature | volume = 406 | issue = 6794 | pages = 430–5 |date=Aug 2000 | pmid = 10935642 | pmc = | doi = 10.1038/35019108 }}</ref><ref name="pmid11807090">{{cite journal | vauthors = Kang D, Chen J, Wong J, Fang G | title = The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition | journal = J Cell Biol | volume = 156 | issue = 2 | pages = 249–59 |date=Jan 2002 | pmid = 11807090 | pmc = 2199220 | doi = 10.1083/jcb.200108016 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHFR checkpoint with forkhead and ring finger domains| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55743| accessdate = }}</ref> | ||
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==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|CHFR}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | author= | *{{cite journal | author=Chaturvedi P |title=Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity |journal=Cancer Res. |volume=62 |issue= 6 |pages= 1797–801 |year= 2002 |pmid= 11912157 |doi= |name-list-format=vanc| author2=Sudakin V | author3=Bobiak ML | display-authors=3 | last4=Fisher | first4=PW | last5=Mattern | first5=MR | last6=Jablonski | first6=SA | last7=Hurle | first7=MR | last8=Zhu | first8=Y | last9=Yen | first9=TJ }} | ||
*{{cite journal | author=Mizuno K |title=Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers |journal=Oncogene |volume=21 |issue= 15 |pages= 2328–33 |year= 2002 |pmid= 11948416 |doi= 10.1038/sj.onc.1205402 |name-list-format=vanc| author2=Osada H | author3=Konishi H | display-authors=3 | last4=Tatematsu | first4=Yoshio | last5=Yatabe | first5=Yasushi | last6=Mitsudomi | first6=Tetsuya | last7=Fujii | first7=Yoshitaka | last8=Takahashi | first8=Takashi }} | |||
*{{cite journal | author=Stavridi ES |title=Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate |journal=Structure |volume=10 |issue= 7 |pages= 891–9 |year= 2002 |pmid= 12121644 |doi=10.1016/S0969-2126(02)00776-1 |name-list-format=vanc| author2=Huyen Y | author3=Loreto IR | display-authors=3 | last4=Scolnick | first4=Daniel M. | last5=Halazonetis | first5=Thanos D. | last6=Pavletich | first6=Nikola P. | last7=Jeffrey | first7=Philip D. }} | |||
*{{cite journal | author=Mizuno K | *{{cite journal | author=Shibata Y |title=Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer |journal=Carcinogenesis |volume=23 |issue= 10 |pages= 1695–9 |year= 2002 |pmid= 12376479 |doi=10.1093/carcin/23.10.1695 |name-list-format=vanc| author2=Haruki N | author3=Kuwabara Y | display-authors=3 | last4=Ishiguro | first4=H | last5=Shinoda | first5=N | last6=Sato | first6=A | last7=Kimura | first7=M | last8=Koyama | first8=H | last9=Toyama | first9=T }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | |||
*{{cite journal | author= | *{{cite journal | author=Corn PG |title=Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer |journal=Carcinogenesis |volume=24 |issue= 1 |pages= 47–51 |year= 2003 |pmid= 12538348 |doi=10.1093/carcin/24.1.47 |name-list-format=vanc| author2=Summers MK | author3=Fogt F | display-authors=3 | last4=Virmani | first4=AK | last5=Gazdar | first5=AF | last6=Halazonetis | first6=TD | last7=El-Deiry | first7=WS }} | ||
*{{cite journal | author=Toyota M |title=Epigenetic inactivation of CHFR in human tumors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 13 |pages= 7818–23 |year= 2003 |pmid= 12810945 |doi= 10.1073/pnas.1337066100 | pmc=164671 |name-list-format=vanc| author2=Sasaki Y | author3=Satoh A | display-authors=3 | last4=Ogi | first4=K | last5=Kikuchi | first5=T | last6=Suzuki | first6=H | last7=Mita | first7=H | last8=Tanaka | first8=N | last9=Itoh | first9=F }} | |||
*{{cite journal | author=Bothos J |title=The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains |journal=Oncogene |volume=22 |issue= 46 |pages= 7101–7 |year= 2003 |pmid= 14562038 |doi= 10.1038/sj.onc.1206831 |name-list-format=vanc| author2=Summers MK | author3=Venere M | display-authors=3 | last4=Scolnick | first4=Daniel M | last5=Halazonetis | first5=Thanos D }} | |||
*{{cite journal | author=Mariatos G |title=Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer |journal=Cancer Res. |volume=63 |issue= 21 |pages= 7185–9 |year= 2004 |pmid= 14612512 |doi= |name-list-format=vanc| author2=Bothos J | author3=Zacharatos P | display-authors=3 | last4=Summers | first4=MK | last5=Scolnick | first5=DM | last6=Kittas | first6=C | last7=Halazonetis | first7=TD | last8=Gorgoulis | first8=VG }} | |||
*{{cite journal | author=Shtivelman E |title=Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR |journal=Mol. Cancer Res. |volume=1 |issue= 13 |pages= 959–69 |year= 2004 |pmid= 14638868 |doi= }} | |||
*{{cite journal | author=Bertholon J |title=Chfr inactivation is not associated to chromosomal instability in colon cancers |journal=Oncogene |volume=22 |issue= 55 |pages= 8956–60 |year= 2004 |pmid= 14654793 |doi= 10.1038/sj.onc.1207078 |name-list-format=vanc| author2=Wang Q | author3=Falette N | display-authors=3 | last4=Verny | first4=Carole | last5=Auclair | first5=Jessie | last6=Chassot | first6=Christelle | last7=Navarro | first7=Claudine | last8=Saurin | first8=Jean-Christophe | last9=Puisieux | first9=Alain }} | |||
*{{cite journal | author= | *{{cite journal | vauthors=Erson AE, Petty EM |title=CHFR-associated early G2/M checkpoint defects in breast cancer cells |journal=Mol. Carcinog. |volume=39 |issue= 1 |pages= 26–33 |year= 2004 |pmid= 14694445 |doi= 10.1002/mc.10161 }} | ||
*{{cite journal | author=Satoh A |title=Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer |journal=Cancer Res. |volume=63 |issue= 24 |pages= 8606–13 |year= 2004 |pmid= 14695171 |doi= |name-list-format=vanc| author2=Toyota M | author3=Itoh F | display-authors=3 | last4=Sasaki | first4=Y | last5=Suzuki | first5=H | last6=Ogi | first6=K | last7=Kikuchi | first7=T | last8=Mita | first8=H | last9=Yamashita | first9=T }} | |||
*{{cite journal | author= | *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | ||
*{{cite journal | author=Kang HC |title=Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers |journal=Oncol. Rep. |volume=12 |issue= 1 |pages= 129–33 |year= 2005 |pmid= 15201973 |doi= 10.3892/or.12.1.129|name-list-format=vanc| author2=Kim IJ | author3=Park JH | display-authors=3 | last4=Shin | first4=Y | last5=Park | first5=HW | last6=Ku | first6=JL | last7=Yang | first7=HK | last8=Lee | first8=KU | last9=Choe | first9=KJ }} | |||
*{{cite journal | author= | *{{cite journal | vauthors=Matsusaka T, Pines J |title=Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells |journal=J. Cell Biol. |volume=166 |issue= 4 |pages= 507–16 |year= 2004 |pmid= 15302856 |doi= 10.1083/jcb.200401139 | pmc=2172205 }} | ||
*{{cite journal | vauthors=Daniels MJ, Marson A, Venkitaraman AR |title=PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 11 |pages= 1114–21 |year= 2004 |pmid= 15467728 |doi= 10.1038/nsmb837 }} | |||
*{{cite journal | author= | *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author= | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=55743}} | |||
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{{ | {{gene-12-stub}} | ||
Latest revision as of 08:34, 2 November 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
| Entrez |
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| Ensembl |
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| UniProt |
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| RefSeq (mRNA) |
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| RefSeq (protein) |
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
| Wikidata | |||||||
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E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.[1][2][3]
References
- ↑ Scolnick DM, Halazonetis TD (Aug 2000). "Chfr defines a mitotic stress checkpoint that delays entry into metaphase". Nature. 406 (6794): 430–5. doi:10.1038/35019108. PMID 10935642.
- ↑ Kang D, Chen J, Wong J, Fang G (Jan 2002). "The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition". J Cell Biol. 156 (2): 249–59. doi:10.1083/jcb.200108016. PMC 2199220. PMID 11807090.
- ↑ "Entrez Gene: CHFR checkpoint with forkhead and ring finger domains".
External links
- Human CHFR genome location and CHFR gene details page in the UCSC Genome Browser.
Further reading
- Chaturvedi P, Sudakin V, Bobiak ML, et al. (2002). "Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity". Cancer Res. 62 (6): 1797–801. PMID 11912157.
- Mizuno K, Osada H, Konishi H, et al. (2002). "Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers". Oncogene. 21 (15): 2328–33. doi:10.1038/sj.onc.1205402. PMID 11948416.
- Stavridi ES, Huyen Y, Loreto IR, et al. (2002). "Crystal structure of the FHA domain of the Chfr mitotic checkpoint protein and its complex with tungstate". Structure. 10 (7): 891–9. doi:10.1016/S0969-2126(02)00776-1. PMID 12121644.
- Shibata Y, Haruki N, Kuwabara Y, et al. (2002). "Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer". Carcinogenesis. 23 (10): 1695–9. doi:10.1093/carcin/23.10.1695. PMID 12376479.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Corn PG, Summers MK, Fogt F, et al. (2003). "Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer". Carcinogenesis. 24 (1): 47–51. doi:10.1093/carcin/24.1.47. PMID 12538348.
- Toyota M, Sasaki Y, Satoh A, et al. (2003). "Epigenetic inactivation of CHFR in human tumors". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7818–23. doi:10.1073/pnas.1337066100. PMC 164671. PMID 12810945.
- Bothos J, Summers MK, Venere M, et al. (2003). "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains". Oncogene. 22 (46): 7101–7. doi:10.1038/sj.onc.1206831. PMID 14562038.
- Mariatos G, Bothos J, Zacharatos P, et al. (2004). "Inactivating mutations targeting the chfr mitotic checkpoint gene in human lung cancer". Cancer Res. 63 (21): 7185–9. PMID 14612512.
- Shtivelman E (2004). "Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR". Mol. Cancer Res. 1 (13): 959–69. PMID 14638868.
- Bertholon J, Wang Q, Falette N, et al. (2004). "Chfr inactivation is not associated to chromosomal instability in colon cancers". Oncogene. 22 (55): 8956–60. doi:10.1038/sj.onc.1207078. PMID 14654793.
- Erson AE, Petty EM (2004). "CHFR-associated early G2/M checkpoint defects in breast cancer cells". Mol. Carcinog. 39 (1): 26–33. doi:10.1002/mc.10161. PMID 14694445.
- Satoh A, Toyota M, Itoh F, et al. (2004). "Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer". Cancer Res. 63 (24): 8606–13. PMID 14695171.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kang HC, Kim IJ, Park JH, et al. (2005). "Promoter hypermethylation and silencing of CHFR mitotic stress checkpoint gene in human gastric cancers". Oncol. Rep. 12 (1): 129–33. doi:10.3892/or.12.1.129. PMID 15201973.
- Matsusaka T, Pines J (2004). "Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells". J. Cell Biol. 166 (4): 507–16. doi:10.1083/jcb.200401139. PMC 2172205. PMID 15302856.
- Daniels MJ, Marson A, Venkitaraman AR (2004). "PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein". Nat. Struct. Mol. Biol. 11 (11): 1114–21. doi:10.1038/nsmb837. PMID 15467728.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
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