CHMP5: Difference between revisions

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{{Infobox_gene}}
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'''Charged multivesicular body protein 5''' is a [[protein]] that in humans is encoded by the ''CHMP5'' [[gene]].<ref name="pmid15644320">{{cite journal | vauthors = Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J | title = The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells | journal = J Biol Chem | volume = 280 | issue = 11 | pages = 10548–55 |date=Mar 2005 | pmid = 15644320 | pmc =  | doi = 10.1074/jbc.M413734200 }}</ref><ref name="pmid11559748">{{cite journal | vauthors = Howard TL, Stauffer DR, Degnin CR, Hollenberg SM | title = CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins | journal = J Cell Sci | volume = 114 | issue = Pt 13 | pages = 2395–404 |date=Sep 2001 | pmid = 11559748 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHMP5 chromatin modifying protein 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51510| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chromatin modifying protein 5
| HGNCid = 26942
| Symbol = CHMP5
| AltSymbols =; C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2
| OMIM = 
| ECnumber = 
| Homologene = 5757
| MGIid = 1924209
| GeneAtlas_image1 = PBB_GE_CHMP5_218085_at_tn.png
| GeneAtlas_image2 = PBB_GE_CHMP5_219356_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001919 |text = regulation of receptor recycling}} {{GNF_GO|id=GO:0007040 |text = lysosome organization and biogenesis}} {{GNF_GO|id=GO:0008333 |text = endosome to lysosome transport}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51510
    | Hs_Ensembl = ENSG00000086065
    | Hs_RefseqProtein = NP_057494
    | Hs_RefseqmRNA = NM_016410
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 33254167
    | Hs_GenLoc_end = 33271525
    | Hs_Uniprot = Q9NZZ3
    | Mm_EntrezGene = 76959
    | Mm_Ensembl = ENSMUSG00000028419
    | Mm_RefseqmRNA = NM_029814
    | Mm_RefseqProtein = NP_084090
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 41137224
    | Mm_GenLoc_end = 41153973
    | Mm_Uniprot = Q9D7S9
  }}
}}
'''Chromatin modifying protein 5''', also known as '''CHMP5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHMP5 chromatin modifying protein 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51510| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CHMP5 belongs to the [[chromatin]]-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of [[ESCRT-III]] (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies ([[endosome|MVBs]]). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, [[CHMP1A]], is required for both MVB formation and regulation of [[cell cycle]] progression.<ref name="entrez"/><ref name="pmid16730941">{{cite journal | vauthors = Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM | title = A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex | journal = Genomics | volume = 88 | issue = 3 | pages = 333–46 |date=September 2006 | pmid = 16730941 | doi = 10.1016/j.ygeno.2006.04.003 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CHMP5}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Lai CH, Chou CY, Ch'ang LY |title=Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=10.1101/gr.10.5.703 | pmc=310876  |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934  |display-authors=etal}}
*{{cite journal  | author=Lai CH, Chou CY, Ch'ang LY, ''et al.'' |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703-13 |year= 2000 |pmid= 10810093 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi= }}
*{{cite journal  | vauthors=Strack B, Calistri A, Craig S |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding |journal=Cell |volume=114 |issue= 6 |pages= 689–99 |year= 2003 |pmid= 14505569 |doi=10.1016/S0092-8674(03)00653-6 |display-authors=etal}}
*{{cite journal  | author=Howard TL, Stauffer DR, Degnin CR, Hollenberg SM |title=CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. |journal=J. Cell. Sci. |volume=114 |issue= Pt 13 |pages= 2395-404 |year= 2002 |pmid= 11559748 |doi=  }}
*{{cite journal  | vauthors=von Schwedler UK, Stuchell M, Müller B |title=The protein network of HIV budding |journal=Cell |volume=114 |issue= 6 |pages= 701–13 |year= 2003 |pmid= 14505570 |doi=10.1016/S0092-8674(03)00714-1 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Martin-Serrano J, Yarovoy A, Perez-Caballero D |title=Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12414–9 |year= 2003 |pmid= 14519844 |doi= 10.1073/pnas.2133846100 | pmc=218772 |display-authors=etal}}
*{{cite journal  | author=Strack B, Calistri A, Craig S, ''et al.'' |title=AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. |journal=Cell |volume=114 |issue= 6 |pages= 689-99 |year= 2003 |pmid= 14505569 |doi=  }}
*{{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |display-authors=etal}}
*{{cite journal  | author=von Schwedler UK, Stuchell M, Müller B, ''et al.'' |title=The protein network of HIV budding. |journal=Cell |volume=114 |issue= 6 |pages= 701-13 |year= 2003 |pmid= 14505570 |doi=  }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Martin-Serrano J, Yarovoy A, Perez-Caballero D, ''et al.'' |title=Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 21 |pages= 12414-9 |year= 2003 |pmid= 14519844 |doi= 10.1073/pnas.2133846100 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Ward DM, Vaughn MB, Shiflett SL, ''et al.'' |title=The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10548-55 |year= 2005 |pmid= 15644320 |doi= 10.1074/jbc.M413734200 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Tsang HT, Connell JW, Brown SE, ''et al.'' |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333-46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:39, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Charged multivesicular body protein 5 is a protein that in humans is encoded by the CHMP5 gene.[1][2][3]

Function

CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.[3][4]

References

  1. ↑ Ward DM, Vaughn MB, Shiflett SL, White PL, Pollock AL, Hill J, Schnegelberger R, Sundquist WI, Kaplan J (Mar 2005). "The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells". J Biol Chem. 280 (11): 10548–55. doi:10.1074/jbc.M413734200. PMID 15644320.
  2. ↑ Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (Sep 2001). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins". J Cell Sci. 114 (Pt 13): 2395–404. PMID 11559748.
  3. ↑ 3.0 3.1 "Entrez Gene: CHMP5 chromatin modifying protein 5".
  4. ↑ Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (September 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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