CHST2: Difference between revisions

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{{Infobox_gene}}
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'''Carbohydrate sulfotransferase 2''' is an [[enzyme]] that in humans is encoded by the ''CHST2'' [[gene]].<ref name="pmid10049591">{{cite journal | vauthors = Li X, Tedder TF | title = CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization | journal = Genomics | volume = 55 | issue = 3 | pages = 345–7 |date=May 1999 | pmid = 10049591 | pmc =  | doi = 10.1006/geno.1998.5653 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9435| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
| HGNCid = 1970
| Symbol = CHST2
| AltSymbols =; C6ST
| OMIM = 603798
| ECnumber = 
| Homologene = 3150
| MGIid = 1891160
| GeneAtlas_image1 = PBB_GE_CHST2_203921_at_tn.png
| Function = {{GNF_GO|id=GO:0001517 |text = N-acetylglucosamine 6-O-sulfotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005802 |text = trans-Golgi network}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0031228 |text = intrinsic to Golgi membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006044 |text = N-acetylglucosamine metabolic process}} {{GNF_GO|id=GO:0006790 |text = sulfur metabolic process}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9435
    | Hs_Ensembl = ENSG00000175040
    | Hs_RefseqProtein = NP_004258
    | Hs_RefseqmRNA = NM_004267
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 144320863
    | Hs_GenLoc_end = 144324500
    | Hs_Uniprot = Q9Y4C5
    | Mm_EntrezGene = 54371
    | Mm_Ensembl = ENSMUSG00000033350
    | Mm_RefseqmRNA = NM_018763
    | Mm_RefseqProtein = NP_061233
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 95213460
    | Mm_GenLoc_end = 95216009
    | Mm_Uniprot = Q3V2H8
  }}
}}
'''Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2''', also known as '''CHST2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9435| accessdate = }}</ref>
 
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CHST2}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Bernstein HB, Compans RW |title=Sulfation of the human immunodeficiency virus envelope glycoprotein. |journal=J. Virol. |volume=66 |issue= 12 |pages= 6953-9 |year= 1992 |pmid= 1433500 |doi=  }}
*{{cite journal  | vauthors=Bernstein HB, Compans RW |title=Sulfation of the human immunodeficiency virus envelope glycoprotein. |journal=J. Virol. |volume=66 |issue= 12 |pages= 6953–9 |year= 1992 |pmid= 1433500 |doi= | pmc=240329 }}
*{{cite journal  | author=Shilatifard A, Merkle RK, Helland DE, ''et al.'' |title=Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine. |journal=J. Virol. |volume=67 |issue= 2 |pages= 943-52 |year= 1993 |pmid= 8419650 |doi=  }}
*{{cite journal  | vauthors=Shilatifard A, Merkle RK, Helland DE |title=Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine. |journal=J. Virol. |volume=67 |issue= 2 |pages= 943–52 |year= 1993 |pmid= 8419650 |doi=  | pmc=237448  |display-authors=etal}}
*{{cite journal  | author=Uchimura K, Muramatsu H, Kadomatsu K, ''et al.'' |title=Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22577-83 |year= 1998 |pmid= 9712885 |doi=  }}
*{{cite journal  | vauthors=Uchimura K, Muramatsu H, Kadomatsu K |title=Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22577–83 |year= 1998 |pmid= 9712885 |doi=10.1074/jbc.273.35.22577 |display-authors=etal}}
*{{cite journal  | author=Uchimura K, Muramatsu H, Kaname T, ''et al.'' |title=Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells. |journal=J. Biochem. |volume=124 |issue= 3 |pages= 670-8 |year= 1998 |pmid= 9722682 |doi=  }}
*{{cite journal  | vauthors=Uchimura K, Muramatsu H, Kaname T |title=Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells. |journal=J. Biochem. |volume=124 |issue= 3 |pages= 670–8 |year= 1998 |pmid= 9722682 |doi=  10.1093/oxfordjournals.jbchem.a022164|display-authors=etal}}
*{{cite journal  | author=Li X, Tedder TF |title=CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization. |journal=Genomics |volume=55 |issue= 3 |pages= 345-7 |year= 1999 |pmid= 10049591 |doi= 10.1006/geno.1998.5653 }}
*{{cite journal  | vauthors=Tu L, Murphy PG, Li X, Tedder TF |title=L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. |journal=J. Immunol. |volume=163 |issue= 9 |pages= 5070–8 |year= 1999 |pmid= 10528213 |doi=  }}
*{{cite journal  | author=Tu L, Murphy PG, Li X, Tedder TF |title=L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1. |journal=J. Immunol. |volume=163 |issue= 9 |pages= 5070-8 |year= 1999 |pmid= 10528213 |doi=  }}
*{{cite journal  | vauthors=Sakaguchi H, Kitagawa H, Sugahara K |title=Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence. |journal=Biochim. Biophys. Acta |volume=1523 |issue= 2-3 |pages= 269–76 |year= 2000 |pmid= 11042394 |doi=  10.1016/s0304-4165(00)00136-7}}
*{{cite journal  | author=Sakaguchi H, Kitagawa H, Sugahara K |title=Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence. |journal=Biochim. Biophys. Acta |volume=1523 |issue= 2-3 |pages= 269-76 |year= 2000 |pmid= 11042394 |doi=  }}
*{{cite journal  | vauthors=Okuda T, Mita S, Yamauchi S |title=Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. |journal=J. Biochem. |volume=128 |issue= 5 |pages= 763–70 |year= 2001 |pmid= 11056388 |doi=  10.1093/oxfordjournals.jbchem.a022813|display-authors=etal}}
*{{cite journal  | author=Okuda T, Mita S, Yamauchi S, ''et al.'' |title=Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase. |journal=J. Biochem. |volume=128 |issue= 5 |pages= 763-70 |year= 2001 |pmid= 11056388 |doi=  }}
*{{cite journal  | vauthors=Li X, Tu L, Murphy PG |title=CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. |journal=J. Leukoc. Biol. |volume=69 |issue= 4 |pages= 565–74 |year= 2001 |pmid= 11310842 |doi=  |display-authors=etal}}
*{{cite journal  | author=Li X, Tu L, Murphy PG, ''et al.'' |title=CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin. |journal=J. Leukoc. Biol. |volume=69 |issue= 4 |pages= 565-74 |year= 2001 |pmid= 11310842 |doi=  }}
*{{cite journal  | vauthors=Uchimura K, El-Fasakhany FM, Hori M |title=Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 3979–84 |year= 2002 |pmid= 11726653 |doi= 10.1074/jbc.M106587200 |display-authors=etal}}
*{{cite journal  | author=Uchimura K, El-Fasakhany FM, Hori M, ''et al.'' |title=Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression. |journal=J. Biol. Chem. |volume=277 |issue= 6 |pages= 3979-84 |year= 2002 |pmid= 11726653 |doi= 10.1074/jbc.M106587200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Grunwell JR, Rath VL, Rasmussen J |title=Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases. |journal=Biochemistry |volume=41 |issue= 52 |pages= 15590–600 |year= 2003 |pmid= 12501187 |doi=10.1021/bi0269557 |display-authors=etal}}
*{{cite journal  | author=Grunwell JR, Rath VL, Rasmussen J, ''et al.'' |title=Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases. |journal=Biochemistry |volume=41 |issue= 52 |pages= 15590-600 |year= 2003 |pmid= 12501187 |doi=  }}
*{{cite journal  | vauthors=de Graffenried CL, Bertozzi CR |title=Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis. |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 40282–95 |year= 2003 |pmid= 12855678 |doi= 10.1074/jbc.M304928200 }}
*{{cite journal  | author=de Graffenried CL, Bertozzi CR |title=Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis. |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 40282-95 |year= 2003 |pmid= 12855678 |doi= 10.1074/jbc.M304928200 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=de Graffenried CL, Bertozzi CR |title=The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40035–43 |year= 2004 |pmid= 15220337 |doi= 10.1074/jbc.M405709200 }}
*{{cite journal  | author=de Graffenried CL, Bertozzi CR |title=The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40035-43 |year= 2004 |pmid= 15220337 |doi= 10.1074/jbc.M405709200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Chen L, Ichihara-Tanaka K, Muramatsu T |title=Role of the carboxyl-terminal region in the activity of N-acetylglucosamine 6-o-sulfotransferase-1. |journal=J. Biochem. |volume=136 |issue= 5 |pages= 659–64 |year= 2005 |pmid= 15632306 |doi= 10.1093/jb/mvh162 }}
*{{cite journal  | author=Chen L, Ichihara-Tanaka K, Muramatsu T |title=Role of the carboxyl-terminal region in the activity of N-acetylglucosamine 6-o-sulfotransferase-1. |journal=J. Biochem. |volume=136 |issue= 5 |pages= 659-64 |year= 2005 |pmid= 15632306 |doi= 10.1093/jb/mvh162 }}
*{{cite journal  | vauthors=Kanoh A, Seko A, Ideo H |title=Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas. |journal=Glycoconj. J. |volume=23 |issue= 5-6 |pages= 453–60 |year= 2007 |pmid= 16897186 |doi= 10.1007/s10719-006-6979-6 |display-authors=etal}}
*{{cite journal  | author=Kanoh A, Seko A, Ideo H, ''et al.'' |title=Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas. |journal=Glycoconj. J. |volume=23 |issue= 5-6 |pages= 453-60 |year= 2007 |pmid= 16897186 |doi= 10.1007/s10719-006-6979-6 }}
}}
}}
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Latest revision as of 09:41, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Carbohydrate sulfotransferase 2 is an enzyme that in humans is encoded by the CHST2 gene.[1][2]


References

  1. ↑ Li X, Tedder TF (May 1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. 55 (3): 345–7. doi:10.1006/geno.1998.5653. PMID 10049591.
  2. ↑ "Entrez Gene: CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2".

External links

Further reading



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