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{{ | '''Calcium and integrin-binding protein 1''' is a [[protein]] that in humans is encoded by the ''CIB1'' [[gene]].<ref name="pmid9030514">{{cite journal | vauthors = Naik UP, Patel PM, Parise LV | title = Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain | journal = J Biol Chem | volume = 272 | issue = 8 | pages = 4651–4 |date=Apr 1997 | pmid = 9030514 | pmc = | doi =10.1074/jbc.272.8.4651 }}</ref><ref name="pmid10826701">{{cite journal | vauthors = Hattori A, Seki N, Hayashi A, Kozuma S, Saito T | title = Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP) | journal = DNA Seq | volume = 10 | issue = 6 | pages = 415–8 |date=Aug 2000 | pmid = 10826701 | pmc = | doi = 10.3109/10425170009015612}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CIB1 calcium and integrin binding 1 (calmyrin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10519| accessdate = }}</ref> | ||
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| summary_text = The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).<ref name="entrez" | | summary_text = The protein encoded by this gene is a member of the [[calcium-binding protein]] family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent [[protein kinase]] and may play a role in kinase-[[phosphatase]] regulation of [[Non-homologous end joining|DNA end-joining]]. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
CIB1 has been shown to [[Protein-protein interaction|interact]] with [[RAC3]],<ref name=pmid11756406>{{cite journal |last=Haataja |first=Leena |author2=Kaartinen Vesa |author3=Groffen John |author4=Heisterkamp Nora |date=Mar 2002 |title=The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading |journal=J. Biol. Chem. |volume=277 |issue=10 |pages=8321–8 |publisher= |location = United States| issn = 0021-9258| pmid = 11756406 |doi = 10.1074/jbc.M105363200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[PSEN2]],<ref name=pmid10366599>{{cite journal |doi=10.1083/jcb.145.6.1277 |last=Stabler |first=S M |author2=Ostrowski L L|author3=Janicki S M|author4=Monteiro M J |date=Jun 1999 |title=A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein |journal=J. Cell Biol. |volume=145 |issue=6 |pages=1277–92 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 10366599 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2133148 }}</ref> [[DNA-PKcs]],<ref name=pmid9372844>{{cite journal |last=Wu |first=X |author2=Lieber M R |date=Oct 1997 |title=Interaction between DNA-dependent protein kinase and a novel protein, KIP |journal=Mutat. Res. |volume=385 |issue=1 |pages=13–20 |publisher= |location = NETHERLANDS| issn = 0027-5107| pmid = 9372844 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.1016/s0921-8777(97)00035-9}}</ref> [[UBR5]]<ref name=pmid12011095>{{cite journal |last=Henderson |first=Michelle J |author2=Russell Amanda J |author3=Hird Samantha |author4=Muñoz Marcia |author5=Clancy Jennifer L |author6=Lehrbach Gillian M |author7=Calanni Sophina T |author8=Jans David A |author9=Sutherland Robert L |author10=Watts Colin K W |date=Jul 2002 |title=EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response |journal=J. Biol. Chem. |volume=277 |issue=29 |pages=26468–78 |publisher= |location = United States| issn = 0021-9258| pmid = 12011095 |doi = 10.1074/jbc.M203527200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[CD61]].<ref name=pmid9030514 /> | |||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|CIB1}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Wu X, Lieber MR |title=Interaction between DNA-dependent protein kinase and a novel protein, KIP. |journal=Mutat. Res. |volume=385 |issue= 1 |pages= 13–20 |year= 1997 |pmid= 9372844 |doi= 10.1016/s0921-8777(97)00035-9}} | ||
*{{cite journal | | *{{cite journal | vauthors=Seki N, Hayashi A, Abe M |title=Chromosomal assignment of the gene for human DNA-PKcs interacting protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid analysis and fluorescence in situ hybridization. |journal=J. Hum. Genet. |volume=43 |issue= 4 |pages= 275–7 |year= 1999 |pmid= 9852683 |doi=10.1007/s100380050089 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Stabler SM, Ostrowski LL, Janicki SM, Monteiro MJ |title=A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein. |journal=J. Cell Biol. |volume=145 |issue= 6 |pages= 1277–92 |year= 1999 |pmid= 10366599 |doi=10.1083/jcb.145.6.1277 | pmc=2133148 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Kauselmann G, Weiler M, Wulff P |title=The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5528–39 |year= 1999 |pmid= 10523297 |doi= 10.1093/emboj/18.20.5528 | pmc=1171621 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Hwang PM, Vogel HJ |title=Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies. |journal=J. Mol. Recognit. |volume=13 |issue= 2 |pages= 83–92 |year= 2000 |pmid= 10822252 |doi= 10.1002/(SICI)1099-1352(200003/04)13:2<83::AID-JMR491>3.0.CO;2-A }} | ||
*{{cite journal | | *{{cite journal | vauthors=Holtrich U, Wolf G, Yuan J |title=Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. |journal=Oncogene |volume=19 |issue= 42 |pages= 4832–9 |year= 2000 |pmid= 11039900 |doi= 10.1038/sj.onc.1203845 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Haataja L, Kaartinen V, Groffen J, Heisterkamp N |title=The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8321–8 |year= 2002 |pmid= 11756406 |doi= 10.1074/jbc.M105363200 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Whitehouse C, Chambers J, Howe K |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 538–45 |year= 2002 |pmid= 11856312 |doi=10.1046/j.0014-2956.2001.02681.x |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Hollenbach AD, McPherson CJ, Lagutina I, Grosveld G |title=The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 3 |pages= 321–8 |year= 2002 |pmid= 11997098 |doi= 10.1016/s0167-4781(02)00230-0}} | ||
*{{cite journal | | *{{cite journal | vauthors=Henderson MJ, Russell AJ, Hird S |title=EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26468–78 |year= 2002 |pmid= 12011095 |doi= 10.1074/jbc.M203527200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Barry WT, Boudignon-Proudhon C, Shock DD |title=Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28877–83 |year= 2002 |pmid= 12023286 |doi= 10.1074/jbc.M202983200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Ma S, Liu MA, Yuan YL, Erikson RL |title=The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB. |journal=Mol. Cancer Res. |volume=1 |issue= 5 |pages= 376–84 |year= 2003 |pmid= 12651910 |doi= }} | ||
*{{cite journal | | *{{cite journal | vauthors=Naik UP, Naik MU |title=Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen. |journal=Blood |volume=102 |issue= 4 |pages= 1355–62 |year= 2003 |pmid= 12714504 |doi= 10.1182/blood-2003-02-0591 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Naik MU, Naik UP |title=Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen. |journal=Blood |volume=102 |issue= 10 |pages= 3629–36 |year= 2004 |pmid= 12881299 |doi= 10.1182/blood-2003-05-1703 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Yamniuk AP, Nguyen LT, Hoang TT, Vogel HJ |title=Metal ion binding properties and conformational states of calcium- and integrin-binding protein. |journal=Biochemistry |volume=43 |issue= 9 |pages= 2558–68 |year= 2004 |pmid= 14992593 |doi= 10.1021/bi035432b }} | ||
*{{cite journal | | *{{cite journal | vauthors=Lee GE, Yu EY, Cho CH |title=DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 34750–5 |year= 2004 |pmid= 15190070 |doi= 10.1074/jbc.M401843200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=10519}} | |||
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{{gene-15-stub}} | |||
[[Category:EF-hand-containing proteins]] | |||
Revision as of 09:42, 30 August 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
| PubMed search | n/a | n/a | |||||
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Calcium and integrin-binding protein 1 is a protein that in humans is encoded by the CIB1 gene.[1][2][3]
The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end-joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).[3]
Interactions
CIB1 has been shown to interact with RAC3,[4] PSEN2,[5] DNA-PKcs,[6] UBR5[7] and CD61.[1]
References
- ↑ 1.0 1.1 Naik UP, Patel PM, Parise LV (Apr 1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain". J Biol Chem. 272 (8): 4651–4. doi:10.1074/jbc.272.8.4651. PMID 9030514.
- ↑ Hattori A, Seki N, Hayashi A, Kozuma S, Saito T (Aug 2000). "Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP)". DNA Seq. 10 (6): 415–8. doi:10.3109/10425170009015612. PMID 10826701.
- ↑ 3.0 3.1 "Entrez Gene: CIB1 calcium and integrin binding 1 (calmyrin)".
- ↑ Haataja, Leena; Kaartinen Vesa; Groffen John; Heisterkamp Nora (Mar 2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. United States. 277 (10): 8321–8. doi:10.1074/jbc.M105363200. ISSN 0021-9258. PMID 11756406.
- ↑ Stabler, S M; Ostrowski L L; Janicki S M; Monteiro M J (Jun 1999). "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. Cell Biol. UNITED STATES. 145 (6): 1277–92. doi:10.1083/jcb.145.6.1277. ISSN 0021-9525. PMC 2133148. PMID 10366599.
- ↑ Wu, X; Lieber M R (Oct 1997). "Interaction between DNA-dependent protein kinase and a novel protein, KIP". Mutat. Res. NETHERLANDS. 385 (1): 13–20. doi:10.1016/s0921-8777(97)00035-9. ISSN 0027-5107. PMID 9372844.
- ↑ Henderson, Michelle J; Russell Amanda J; Hird Samantha; Muñoz Marcia; Clancy Jennifer L; Lehrbach Gillian M; Calanni Sophina T; Jans David A; Sutherland Robert L; Watts Colin K W (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. United States. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095.
External links
- Human CIB1 genome location and CIB1 gene details page in the UCSC Genome Browser.
Further reading
- Wu X, Lieber MR (1997). "Interaction between DNA-dependent protein kinase and a novel protein, KIP". Mutat. Res. 385 (1): 13–20. doi:10.1016/s0921-8777(97)00035-9. PMID 9372844.
- Seki N, Hayashi A, Abe M, et al. (1999). "Chromosomal assignment of the gene for human DNA-PKcs interacting protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid analysis and fluorescence in situ hybridization". J. Hum. Genet. 43 (4): 275–7. doi:10.1007/s100380050089. PMID 9852683.
- Stabler SM, Ostrowski LL, Janicki SM, Monteiro MJ (1999). "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. Cell Biol. 145 (6): 1277–92. doi:10.1083/jcb.145.6.1277. PMC 2133148. PMID 10366599.
- Kauselmann G, Weiler M, Wulff P, et al. (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity". EMBO J. 18 (20): 5528–39. doi:10.1093/emboj/18.20.5528. PMC 1171621. PMID 10523297.
- Hwang PM, Vogel HJ (2000). "Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies". J. Mol. Recognit. 13 (2): 83–92. doi:10.1002/(SICI)1099-1352(200003/04)13:2<83::AID-JMR491>3.0.CO;2-A. PMID 10822252.
- Holtrich U, Wolf G, Yuan J, et al. (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages". Oncogene. 19 (42): 4832–9. doi:10.1038/sj.onc.1203845. PMID 11039900.
- Haataja L, Kaartinen V, Groffen J, Heisterkamp N (2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. 277 (10): 8321–8. doi:10.1074/jbc.M105363200. PMID 11756406.
- Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–45. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.
- Hollenbach AD, McPherson CJ, Lagutina I, Grosveld G (2002). "The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3". Biochim. Biophys. Acta. 1574 (3): 321–8. doi:10.1016/s0167-4781(02)00230-0. PMID 11997098.
- Henderson MJ, Russell AJ, Hird S, et al. (2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. PMID 12011095.
- Barry WT, Boudignon-Proudhon C, Shock DD, et al. (2002). "Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain". J. Biol. Chem. 277 (32): 28877–83. doi:10.1074/jbc.M202983200. PMID 12023286.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ma S, Liu MA, Yuan YL, Erikson RL (2003). "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB". Mol. Cancer Res. 1 (5): 376–84. PMID 12651910.
- Naik UP, Naik MU (2003). "Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen". Blood. 102 (4): 1355–62. doi:10.1182/blood-2003-02-0591. PMID 12714504.
- Naik MU, Naik UP (2004). "Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen". Blood. 102 (10): 3629–36. doi:10.1182/blood-2003-05-1703. PMID 12881299.
- Yamniuk AP, Nguyen LT, Hoang TT, Vogel HJ (2004). "Metal ion binding properties and conformational states of calcium- and integrin-binding protein". Biochemistry. 43 (9): 2558–68. doi:10.1021/bi035432b. PMID 14992593.
- Lee GE, Yu EY, Cho CH, et al. (2004). "DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase". J. Biol. Chem. 279 (33): 34750–5. doi:10.1074/jbc.M401843200. PMID 15190070.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
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